ID   NU6M_SALSA              Reviewed;         173 AA.
AC   Q9ZZM2;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 6;
GN   Name=MT-ND6; Synonyms=MTND6, NADH6, ND6;
OS   Salmo salar (Atlantic salmon).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=10548724; DOI=10.1016/s0378-1119(99)00425-4;
RA   Hurst C.D., Bartlett S.E., Davidson W.S., Bruce I.J.;
RT   "The complete mitochondrial DNA sequence of the Atlantic salmon, Salmo
RT   salar.";
RL   Gene 239:237-242(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Arnason U., Johnsson E., Rasmussen A.S.;
RT   "The complete mitochondrial genome sequence of a teleost, Salmo salar, and
RT   comparisons with other salmoniformes.";
RL   Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR   EMBL; U12143; AAD04744.1; -; Genomic_DNA.
DR   EMBL; AF133701; AAF61389.1; -; Genomic_DNA.
DR   PIR; T09958; T09958.
DR   RefSeq; NP_008456.1; NC_001960.1.
DR   AlphaFoldDB; Q9ZZM2; -.
DR   SMR; Q9ZZM2; -.
DR   STRING; 8030.ENSSSAP00000000013; -.
DR   GeneID; 808317; -.
DR   KEGG; sasa:808317; -.
DR   CTD; 4541; -.
DR   OMA; YLGGMMV; -.
DR   OrthoDB; 1438416at2759; -.
DR   Proteomes; UP000087266; Mitochondrion MT.
DR   Bgee; ENSSSAG00000000034; Expressed in zone of skin and 16 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.20.120.1200; -; 1.
DR   InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR   InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR   Pfam; PF00499; Oxidored_q3; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; NAD; Reference proteome;
KW   Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..173
FT                   /note="NADH-ubiquinone oxidoreductase chain 6"
FT                   /id="PRO_0000118330"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   173 AA;  18388 MW;  55322B94E972CE17 CRC64;
     MTYIVSLFLL GLVLGLVAVA SNPAPYFAAL GLVVAAGVGC GVLVGYGGSF LSLVLFLIYL
     GGMLVVFAYS AALAAEPFPE SWGDRSVLGY VVVYTVGVML VAGWFWSGWY ETSWVVVDEF
     KEFSVLRGDT SGVALMYSYG GGMLIVCAWV LLLTLFVVLE LTRGLSRGAL RAV