ID   NU6M_SARGL              Reviewed;         185 AA.
AC   O63849;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 6;
GN   Name=ND6;
OS   Sarcophyton glaucum (Toadstool umbrella leather coral).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Octocorallia; Alcyonacea;
OC   Alcyoniina; Alcyoniidae; Sarcophyton.
OX   NCBI_TaxID=70919;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9541536; DOI=10.1007/pl00006321;
RA   Pont-Kingdon G., Okada N.A., Macfarlane J.L., Beagley C.T.,
RA   Watkins-Sims C.D., Cavalier-Smith T., Clark-Walker G.D., Wolstenholme D.R.;
RT   "Mitochondrial DNA of the coral Sarcophyton glaucum contains a gene for a
RT   homologue of bacterial MutS: a possible case of gene transfer from the
RT   nucleus to the mitochondrion.";
RL   J. Mol. Evol. 46:419-431(1998).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR   EMBL; AF063191; AAC16383.1; -; Genomic_DNA.
DR   AlphaFoldDB; O63849; -.
DR   SMR; O63849; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.20.120.1200; -; 1.
DR   InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR   InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR   Pfam; PF00499; Oxidored_q3; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW   Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..185
FT                   /note="NADH-ubiquinone oxidoreductase chain 6"
FT                   /id="PRO_0000118331"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   185 AA;  20516 MW;  9B99F7AB862D12D1 CRC64;
     MNSLFMIFSL GIVGASLMVI STPNPVYSVF WLVIAFVNAA VMFISLGLDY IGLIFIIVYV
     GAIAILFLFV IMLIQQPNKI DSQDHSHFLP IGLSVIFLFY SLLTNSPKYI SNPVIGSRTN
     IGAIGSHLYT TYYELVLIAS LVLLVAMIGA ILLAKQPNSP FLYNSHGESL RSRQDLFLQI
     SREHL