NU6M_SHEEP
ID NU6M_SHEEP Reviewed; 175 AA.
AC O78757;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03923};
DE AltName: Full=NADH dehydrogenase subunit 6;
GN Name=MT-ND6; Synonyms=MTND6, NADH6, ND6;
OS Ovis aries (Sheep).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Merinolandschaf {ECO:0000312|Proteomes:UP000002356}; TISSUE=Liver;
RX PubMed=9767689; DOI=10.1007/pl00006401;
RA Hiendleder S., Lewalski H., Wassmuth R., Janke A.;
RT "The complete mitochondrial DNA sequence of the domestic sheep (Ovis aries)
RT and comparison with the other major ovine haplotype.";
RL J. Mol. Evol. 47:441-448(1998).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03923}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03923};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03924}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03924}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR EMBL; AF010406; AAD10106.1; -; Genomic_DNA.
DR PIR; T11061; T11061.
DR RefSeq; NP_008417.1; NC_001941.1.
DR PDB; 5LNK; EM; 3.90 A; J=1-175.
DR PDB; 6Q9B; EM; 3.90 A; D6=1-175.
DR PDB; 6QA9; EM; 4.10 A; D6=1-175.
DR PDB; 6QBX; EM; 4.20 A; D6=1-175.
DR PDB; 6QC2; EM; 4.20 A; D6=1-175.
DR PDB; 6QC3; EM; 4.20 A; D6=1-175.
DR PDB; 6QC4; EM; 4.60 A; D6=1-175.
DR PDB; 6QC5; EM; 4.30 A; D6=1-175.
DR PDB; 6QC6; EM; 4.10 A; D6=1-175.
DR PDB; 6QC7; EM; 4.40 A; D6=1-175.
DR PDB; 6QC8; EM; 4.20 A; D6=1-175.
DR PDB; 6QC9; EM; 5.70 A; D6=1-175.
DR PDB; 6QCA; EM; 6.20 A; D6=1-175.
DR PDB; 6QCF; EM; 6.50 A; D6=1-175.
DR PDB; 6ZKA; EM; 2.50 A; J=1-175.
DR PDB; 6ZKB; EM; 2.90 A; J=1-175.
DR PDB; 6ZKC; EM; 3.10 A; J=1-175.
DR PDB; 6ZKD; EM; 2.70 A; J=1-175.
DR PDB; 6ZKE; EM; 2.60 A; J=1-175.
DR PDB; 6ZKF; EM; 2.80 A; J=1-175.
DR PDB; 6ZKG; EM; 3.40 A; J=1-175.
DR PDB; 6ZKH; EM; 3.00 A; J=1-175.
DR PDB; 6ZKI; EM; 2.80 A; J=1-175.
DR PDB; 6ZKJ; EM; 3.00 A; J=1-175.
DR PDB; 6ZKK; EM; 3.70 A; J=1-175.
DR PDB; 6ZKL; EM; 3.10 A; J=1-175.
DR PDB; 6ZKM; EM; 2.80 A; J=1-175.
DR PDB; 6ZKN; EM; 2.90 A; J=1-175.
DR PDB; 6ZKO; EM; 3.80 A; J=1-175.
DR PDB; 6ZKP; EM; 3.20 A; J=1-175.
DR PDB; 6ZKQ; EM; 3.30 A; J=1-175.
DR PDB; 6ZKR; EM; 3.50 A; J=1-175.
DR PDB; 6ZKS; EM; 3.10 A; J=1-175.
DR PDB; 6ZKT; EM; 2.80 A; J=1-175.
DR PDB; 6ZKU; EM; 3.00 A; J=1-175.
DR PDB; 6ZKV; EM; 2.90 A; J=1-175.
DR PDBsum; 5LNK; -.
DR PDBsum; 6Q9B; -.
DR PDBsum; 6QA9; -.
DR PDBsum; 6QBX; -.
DR PDBsum; 6QC2; -.
DR PDBsum; 6QC3; -.
DR PDBsum; 6QC4; -.
DR PDBsum; 6QC5; -.
DR PDBsum; 6QC6; -.
DR PDBsum; 6QC7; -.
DR PDBsum; 6QC8; -.
DR PDBsum; 6QC9; -.
DR PDBsum; 6QCA; -.
DR PDBsum; 6QCF; -.
DR PDBsum; 6ZKA; -.
DR PDBsum; 6ZKB; -.
DR PDBsum; 6ZKC; -.
DR PDBsum; 6ZKD; -.
DR PDBsum; 6ZKE; -.
DR PDBsum; 6ZKF; -.
DR PDBsum; 6ZKG; -.
DR PDBsum; 6ZKH; -.
DR PDBsum; 6ZKI; -.
DR PDBsum; 6ZKJ; -.
DR PDBsum; 6ZKK; -.
DR PDBsum; 6ZKL; -.
DR PDBsum; 6ZKM; -.
DR PDBsum; 6ZKN; -.
DR PDBsum; 6ZKO; -.
DR PDBsum; 6ZKP; -.
DR PDBsum; 6ZKQ; -.
DR PDBsum; 6ZKR; -.
DR PDBsum; 6ZKS; -.
DR PDBsum; 6ZKT; -.
DR PDBsum; 6ZKU; -.
DR PDBsum; 6ZKV; -.
DR AlphaFoldDB; O78757; -.
DR SMR; O78757; -.
DR STRING; 9940.ENSOARP00000000012; -.
DR Ensembl; ENSOART00000000033; ENSOARP00000000012; ENSOARG00000000033.
DR Ensembl; ENSOART00020000032; ENSOARP00020000011; ENSOARG00020000032.
DR GeneID; 808259; -.
DR KEGG; oas:808259; -.
DR CTD; 4541; -.
DR eggNOG; ENOG502S2Q2; Eukaryota.
DR HOGENOM; CLU_129718_0_0_1; -.
DR OMA; YLGGMMV; -.
DR OrthoDB; 1438416at2759; -.
DR Proteomes; UP000002356; Mitochondrion.
DR Bgee; ENSOARG00000000033; Expressed in adult mammalian kidney and 54 other tissues.
DR ExpressionAtlas; O78757; baseline and differential.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR Gene3D; 1.20.120.1200; -; 1.
DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR Pfam; PF00499; Oxidored_q3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; NAD; Reference proteome; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..175
FT /note="NADH-ubiquinone oxidoreductase chain 6"
FT /id="PRO_0000118333"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT HELIX 2..4
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 5..21
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 26..46
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 50..58
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 59..63
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 64..75
FT /evidence="ECO:0007829|PDB:6ZKA"
FT STRAND 83..86
FT /evidence="ECO:0007829|PDB:6ZKB"
FT HELIX 87..110
FT /evidence="ECO:0007829|PDB:6ZKA"
FT STRAND 111..120
FT /evidence="ECO:0007829|PDB:6ZKA"
FT TURN 124..127
FT /evidence="ECO:0007829|PDB:6ZKA"
FT STRAND 128..131
FT /evidence="ECO:0007829|PDB:6ZKB"
FT STRAND 134..136
FT /evidence="ECO:0007829|PDB:6ZKM"
FT HELIX 138..144
FT /evidence="ECO:0007829|PDB:6ZKA"
FT TURN 145..149
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 151..171
FT /evidence="ECO:0007829|PDB:6ZKA"
SQ SEQUENCE 175 AA; 19121 MW; 2C9DB51C780BB83C CRC64;
MMTYIVFILS IIFVMGFVGF SSKPSPIYGG LGLIVSGGVG CGIVLNFGGS FLGLMVFLIY
LGGMMVVFGY TTAMATEQYP EVWVSNKVVL GTFITGLLME FLMVYYVLKD KEVEIVFKFN
GMGDWVIYDT GDSGFFSEEA MGIAALYSYG TWLVIVTGWS LLIGVVVIME ITRGN
