ID   NU6M_STRPU              Reviewed;         165 AA.
AC   P15553;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 6;
GN   Name=ND6;
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3172215; DOI=10.1016/0022-2836(88)90452-4;
RA   Jacobs H.T., Elliott D.J., Math V.B., Farquharson A.;
RT   "Nucleotide sequence and gene organization of sea urchin mitochondrial
RT   DNA.";
RL   J. Mol. Biol. 202:185-217(1988).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR   EMBL; X12631; CAA31161.1; -; Genomic_DNA.
DR   PIR; S01510; S01510.
DR   RefSeq; NP_006976.1; NC_001453.1.
DR   AlphaFoldDB; P15553; -.
DR   SMR; P15553; -.
DR   EnsemblMetazoa; GeneID_2652726_df_mr; NP_006976; GeneID_2652726.
DR   GeneID; 2652726; -.
DR   KEGG; spu:2652726; -.
DR   CTD; 4541; -.
DR   InParanoid; P15553; -.
DR   OMA; YLGGMMV; -.
DR   OrthoDB; 1438416at2759; -.
DR   PhylomeDB; P15553; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.20.120.1200; -; 1.
DR   InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR   InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR   Pfam; PF00499; Oxidored_q3; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; NAD; Reference proteome;
KW   Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..165
FT                   /note="NADH-ubiquinone oxidoreductase chain 6"
FT                   /id="PRO_0000118337"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   165 AA;  18040 MW;  C28FA1BF429C5274 CRC64;
     MVVYVTLIVM LFGSTLVFYS LSPYYSALGL VVFSVPGSFV LSFLGSSFVP IVLFLVYIGG
     MLVVFPYSSA ISPERFPSVN NLGEVVGLVF LFSSWVFMSF DNFQDLKNIF HCFVSGESLV
     GSNTFYNSGG VLVILGVFVL LVALVGALII SRGIESTIIR AIWLW