NU6M_TETNG
ID NU6M_TETNG Reviewed; 173 AA.
AC Q4JQH6;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 6;
GN Name=MT-ND6; Synonyms=MTND6, NADH6, ND6;
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17076253; DOI=10.1080/10425170600700378;
RA Yue G.H., Lo L.C., Zhu Z.Y., Lin G., Feng F.;
RT "The complete nucleotide sequence of the mitochondrial genome of Tetraodon
RT nigroviridis.";
RL DNA Seq. 17:115-121(2006).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR EMBL; DQ019313; AAY26170.1; -; Genomic_DNA.
DR AlphaFoldDB; Q4JQH6; -.
DR SMR; Q4JQH6; -.
DR STRING; 99883.ENSTNIP00000000974; -.
DR Ensembl; ENSTNIT00000003425; ENSTNIP00000000974; ENSTNIG00000000217.
DR GeneTree; ENSGT00390000003988; -.
DR HOGENOM; CLU_129718_0_0_1; -.
DR InParanoid; Q4JQH6; -.
DR OMA; YLGGMMV; -.
DR TreeFam; TF343324; -.
DR Proteomes; UP000007303; Mitochondrion.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.120.1200; -; 1.
DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR Pfam; PF00499; Oxidored_q3; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; NAD; Reference proteome;
KW Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..173
FT /note="NADH-ubiquinone oxidoreductase chain 6"
FT /id="PRO_0000118342"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 173 AA; 18557 MW; B6F7B23AF578BF2A CRC64;
MTYVMSLFLL GLVLGLVAVA SNPSPYFGAL SLVGVAAFGC GVLIWHGGSF LSLVLFLIYL
GGMLVVFAYS AALAAEPYPE TLGSWPVVSV YFGYFFFVFG ILYTNMVLDE EVWWGVSGEM
DWDAVFRGDM DGVSLMYSSG GGVLLLGAWV LLLTLLVVLE LVRGLGRGAL RAV
