NU6M_WHEAT
ID NU6M_WHEAT Reviewed; 247 AA.
AC Q02500;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 6;
GN Name=ND6; Synonyms=NAD6;
OS Triticum aestivum (Wheat).
OG Mitochondrion.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1421143; DOI=10.1007/bf00040599;
RA Haouazine N., de Souza A., Jubier M.-F., Lancelin D., Delcher E.,
RA Lejeune B.;
RT "The wheat mitochondrial genome contains an ORF showing sequence homology
RT to the gene encoding the subunit 6 of the NADH-ubiquinone oxidoreductase.";
RL Plant Mol. Biol. 20:395-404(1992).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR EMBL; X62100; CAA44009.1; -; Genomic_DNA.
DR PIR; S78470; S78470.
DR RefSeq; YP_398421.1; NC_007579.1.
DR AlphaFoldDB; Q02500; -.
DR SMR; Q02500; -.
DR STRING; 4565.EPlTAEP00000010099; -.
DR eggNOG; ENOG502S66Q; Eukaryota.
DR HOGENOM; CLU_085957_5_2_1; -.
DR Genevisible; Q02500; TA.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.120.1200; -; 1.
DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR Pfam; PF00499; Oxidored_q3; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..247
FT /note="NADH-ubiquinone oxidoreductase chain 6"
FT /id="PRO_0000118347"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 247 AA; 28008 MW; EC6E111FE7EF3A68 CRC64;
MRLLAPAFKF HFKGGRRTMI LSVLSSPALV SGLMVVRAKN PVHSVLFPIL VFCDTSGLLI
LLGLDFSAMI SPVVHIGAIA VSFLFVVMMF NIQIAEIHEE VLRYLPVSGI IGLIFWWEMF
FILDNETIPL LPTHRNTTSL RYTVYAGKVR SWTNLETLGN LLYTYYSVWF LVSSLILLVA
MIGAIVLTMH RTTKVKRQDV FRRNALDSRS HIMNRTISPF GHSHRRSFSS GAGGPPDNYK
ETFKMWI
