ID   NU6M_XENLA              Reviewed;         170 AA.
AC   P03927;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE            EC=7.1.1.2 {ECO:0000250|UniProtKB:P03923};
DE   AltName: Full=NADH dehydrogenase subunit 6;
GN   Name=mt-nd6; Synonyms=mtnd6, nadh6, nd6;
OS   Xenopus laevis (African clawed frog).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=4019494; DOI=10.1016/s0021-9258(17)39303-1;
RA   Roe B.A., Ma D.-P., Wilson R.K., Wong J.F.-H.;
RT   "The complete nucleotide sequence of the Xenopus laevis mitochondrial
RT   genome.";
RL   J. Biol. Chem. 260:9759-9774(1985).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. Essential for the catalytic activity and assembly of complex
CC       I. {ECO:0000250|UniProtKB:P03923}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC         Evidence={ECO:0000250|UniProtKB:P03923};
CC   -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC       I) which is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:P03924}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P03924}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR   EMBL; M10217; AAA66469.1; -; Genomic_DNA.
DR   PIR; A00459; DEXLN6.
DR   RefSeq; NP_008145.1; NC_001573.1.
DR   AlphaFoldDB; P03927; -.
DR   SMR; P03927; -.
DR   GeneID; 2642079; -.
DR   KEGG; xla:2642079; -.
DR   CTD; 4541; -.
DR   Xenbase; XB-GENE-6251966; nd6.L.
DR   OrthoDB; 1438416at2759; -.
DR   Proteomes; UP000186698; Mitochondrion MT.
DR   Bgee; 2642079; Expressed in blastula and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   Gene3D; 1.20.120.1200; -; 1.
DR   InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR   InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR   Pfam; PF00499; Oxidored_q3; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW   Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..170
FT                   /note="NADH-ubiquinone oxidoreductase chain 6"
FT                   /id="PRO_0000118348"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   170 AA;  18768 MW;  6214C0B9E63794D1 CRC64;
     MIYMVSVSMM VLVLGLVAVA SNPSPFYAAL GLVLAAGAGC LVIVSFGSSF LSIVLFLIYL
     GGMLVVFAYS AARAKPYPEA WGSWSVVFYV LVYLIGVLVW YLFLGGVEVD GMNKSSELGS
     YVMRGDWVGV ALMYSCWWVI IVYWWVSIII NFVCGIWVNS KSMWWESSCV