NU6M_YARLI
ID NU6M_YARLI Reviewed; 185 AA.
AC Q9B6E9;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 6;
GN Name=ND6;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OG Mitochondrion.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20460 / W29 / CBS 7504 / IFP29;
RX DOI=10.1002/cfg.72;
RA Kerscher S., Durstewitz G., Casaregola S., Gaillardin C., Brandt U.;
RT "The complete mitochondrial genome of Yarrowia lipolytica.";
RL Comp. Funct. Genomics 2:80-90(2001).
RN [2]
RP SUBUNIT.
RX PubMed=15282186; DOI=10.1016/j.bbabio.2004.04.019;
RA Abdrakhmanova A., Zickermann V., Bostina M., Radermacher M., Schagger H.,
RA Kerscher S., Brandt U.;
RT "Subunit composition of mitochondrial complex I from the yeast Yarrowia
RT lipolytica.";
RL Biochim. Biophys. Acta 1658:148-156(2004).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBUNIT: Complex I is composed of 37 different subunits.
CC {ECO:0000269|PubMed:15282186}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR EMBL; AJ307410; CAC28088.2; -; Genomic_DNA.
DR RefSeq; NP_075423.2; NC_002659.1.
DR PDB; 4WZ7; X-ray; 3.60 A; 6=1-185.
DR PDB; 6GCS; EM; 4.32 A; 6=1-185.
DR PDB; 6H8K; X-ray; 3.79 A; 6=11-185.
DR PDB; 6RFQ; EM; 3.30 A; 6=1-185.
DR PDB; 6RFR; EM; 3.20 A; 6=1-185.
DR PDB; 6RFS; EM; 4.04 A; 6=1-185.
DR PDB; 6Y79; EM; 3.20 A; 6=1-185.
DR PDB; 6YJ4; EM; 2.70 A; J=1-185.
DR PDBsum; 4WZ7; -.
DR PDBsum; 6GCS; -.
DR PDBsum; 6H8K; -.
DR PDBsum; 6RFQ; -.
DR PDBsum; 6RFR; -.
DR PDBsum; 6RFS; -.
DR PDBsum; 6Y79; -.
DR PDBsum; 6YJ4; -.
DR AlphaFoldDB; Q9B6E9; -.
DR SMR; Q9B6E9; -.
DR DIP; DIP-61442N; -.
DR IntAct; Q9B6E9; 2.
DR STRING; 284591.Q9B6E9; -.
DR GeneID; 802611; -.
DR KEGG; yli:YalifMp01; -.
DR InParanoid; Q9B6E9; -.
DR Proteomes; UP000001300; Mitochondrion.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IBA:GO_Central.
DR Gene3D; 1.20.120.1200; -; 1.
DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR Pfam; PF00499; Oxidored_q3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Electron transport; Membrane; Mitochondrion; NAD;
KW Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..185
FT /note="NADH-ubiquinone oxidoreductase chain 6"
FT /id="PRO_0000118349"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT HELIX 2..5
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 8..25
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 29..49
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 53..77
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 87..90
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 91..93
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 94..110
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 118..125
FT /evidence="ECO:0007829|PDB:6YJ4"
FT STRAND 130..134
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 146..155
FT /evidence="ECO:0007829|PDB:6YJ4"
FT TURN 156..158
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 159..180
FT /evidence="ECO:0007829|PDB:6YJ4"
SQ SEQUENCE 185 AA; 20758 MW; 0518906B2C20647C CRC64;
MMYLTYYFIE ITIFLAILCT IFIISAKNPM VSILYMIALF VIAAMYLYLI GLGIFSLLYI
MIYIGAIAVL FLFIITLLDI NSTELSVKSN IRDLPLVLIS LIVLTISGLM IYSNDSILIN
KLLEAFGNDY NTIITQDWFN IENTTLLTTI GNVLLTNNAF ILLVLAIVLL LGIIGPISIT
MKHKE
