NU98A_ARATH
ID NU98A_ARATH Reviewed; 1041 AA.
AC Q8RY25; Q9SY83;
DT 26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Nuclear pore complex protein NUP98A {ECO:0000303|PubMed:21189294};
DE AltName: Full=Nucleoporin 98A {ECO:0000303|PubMed:21189294};
DE AltName: Full=Nucleoporin autopeptidase {ECO:0000312|EMBL:AEE28574.1};
GN Name=NUP98A {ECO:0000303|PubMed:21189294};
GN OrderedLocusNames=At1g10390 {ECO:0000312|Araport:AT1G10390};
GN ORFNames=F14N23.29 {ECO:0000312|EMBL:AAL84948.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:AAL84948.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION IN THE NUCLEAR PORE COMPLEX BY MASS SPECTROMETRY, AND
RP NOMENCLATURE.
RX PubMed=21189294; DOI=10.1105/tpc.110.079947;
RA Tamura K., Fukao Y., Iwamoto M., Haraguchi T., Hara-Nishimura I.;
RT "Identification and characterization of nuclear pore complex components in
RT Arabidopsis thaliana.";
RL Plant Cell 22:4084-4097(2010).
CC -!- SUBUNIT: Part of the nuclear pore complex (NPC). The NPC has an eight-
CC fold symmetrical structure comprising a central transport channel and
CC two rings, the cytoplasmic and nuclear rings, to which eight filaments
CC are attached. The cytoplasmic filaments have loose ends, while the
CC nuclear filaments are joined in a distal ring, forming a nuclear
CC basket. NPCs are highly dynamic in configuration and composition, and
CC can be devided in 3 subcomplexes, the NUP62 subcomplex, the NUP107-160
CC subcomplex and the NUP93 subcomplex, containing approximately 30
CC different nucleoporin proteins. {ECO:0000305|PubMed:21189294}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC {ECO:0000305|PubMed:21189294}.
CC -!- DOMAIN: Contains FG repeats mediating the translocation through the NPC
CC by interacting with transport factors. {ECO:0000305}.
CC -!- MISCELLANEOUS: Unlike in mammals and yeast, NUP96 and NUP98 are not
CC translated as a polyprotein. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the nucleoporin GLFG family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD32891.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC005489; AAD32891.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28574.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28575.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM58231.1; -; Genomic_DNA.
DR EMBL; AY078948; AAL84948.1; -; mRNA.
DR EMBL; BT003030; AAO23595.1; -; mRNA.
DR EMBL; AK226964; BAE99032.1; -; mRNA.
DR PIR; H86237; H86237.
DR RefSeq; NP_001031018.1; NM_001035941.2.
DR RefSeq; NP_001320682.1; NM_001331900.1.
DR RefSeq; NP_172510.2; NM_100914.4.
DR AlphaFoldDB; Q8RY25; -.
DR BioGRID; 22819; 3.
DR IntAct; Q8RY25; 1.
DR STRING; 3702.AT1G10390.1; -.
DR MEROPS; S59.A02; -.
DR iPTMnet; Q8RY25; -.
DR PaxDb; Q8RY25; -.
DR PRIDE; Q8RY25; -.
DR ProteomicsDB; 248665; -.
DR EnsemblPlants; AT1G10390.1; AT1G10390.1; AT1G10390.
DR EnsemblPlants; AT1G10390.2; AT1G10390.2; AT1G10390.
DR EnsemblPlants; AT1G10390.3; AT1G10390.3; AT1G10390.
DR GeneID; 837579; -.
DR Gramene; AT1G10390.1; AT1G10390.1; AT1G10390.
DR Gramene; AT1G10390.2; AT1G10390.2; AT1G10390.
DR Gramene; AT1G10390.3; AT1G10390.3; AT1G10390.
DR KEGG; ath:AT1G10390; -.
DR Araport; AT1G10390; -.
DR TAIR; locus:2012788; AT1G10390.
DR eggNOG; KOG0845; Eukaryota.
DR HOGENOM; CLU_012217_0_0_1; -.
DR InParanoid; Q8RY25; -.
DR OMA; GDILWPG; -.
DR OrthoDB; 93359at2759; -.
DR PhylomeDB; Q8RY25; -.
DR PRO; PR:Q8RY25; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8RY25; baseline and differential.
DR Genevisible; Q8RY25; AT.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0005635; C:nuclear envelope; IDA:TAIR.
DR GO; GO:0031965; C:nuclear membrane; IDA:TAIR.
DR GO; GO:0044614; C:nuclear pore cytoplasmic filaments; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0017056; F:structural constituent of nuclear pore; IBA:GO_Central.
DR GO; GO:0006406; P:mRNA export from nucleus; IMP:TAIR.
DR GO; GO:0048573; P:photoperiodism, flowering; IGI:TAIR.
DR GO; GO:0000973; P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery; IBA:GO_Central.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR GO; GO:1902446; P:regulation of shade avoidance; IMP:TAIR.
DR GO; GO:0006405; P:RNA export from nucleus; IBA:GO_Central.
DR Gene3D; 3.30.1610.10; -; 1.
DR InterPro; IPR037665; Nucleoporin_S59-like.
DR InterPro; IPR007230; Nup98_auto-Pept-S59_dom.
DR InterPro; IPR036903; Nup98_auto-Pept-S59_dom_sf.
DR PANTHER; PTHR23198; PTHR23198; 2.
DR Pfam; PF04096; Nucleoporin2; 1.
DR SUPFAM; SSF82215; SSF82215; 1.
DR PROSITE; PS51434; NUP_C; 1.
PE 1: Evidence at protein level;
KW mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW Reference proteome; Repeat; Translocation; Transport.
FT CHAIN 1..1041
FT /note="Nuclear pore complex protein NUP98A"
FT /id="PRO_0000431086"
FT REPEAT 2..3
FT /note="1"
FT REPEAT 8..9
FT /note="2"
FT REPEAT 17..18
FT /note="3"
FT REPEAT 23..24
FT /note="4"
FT REPEAT 41..42
FT /note="5"
FT REPEAT 56..57
FT /note="6"
FT REPEAT 64..65
FT /note="7"
FT REPEAT 79..80
FT /note="8"
FT REPEAT 87..88
FT /note="9"
FT REPEAT 94..95
FT /note="10"
FT REPEAT 103..104
FT /note="11"
FT REPEAT 109..110
FT /note="12"
FT REPEAT 124..125
FT /note="13"
FT REPEAT 135..136
FT /note="14"
FT REPEAT 140..141
FT /note="15"
FT REPEAT 146..147
FT /note="16"
FT REPEAT 154..155
FT /note="17"
FT REPEAT 162..163
FT /note="18"
FT REPEAT 170..171
FT /note="19"
FT REPEAT 178..179
FT /note="20"
FT REPEAT 186..187
FT /note="21"
FT REPEAT 194..195
FT /note="22"
FT REPEAT 202..203
FT /note="23"
FT REPEAT 210..211
FT /note="24"
FT REPEAT 217..218
FT /note="25"
FT REPEAT 222..223
FT /note="26"
FT REPEAT 228..229
FT /note="27"
FT REPEAT 236..237
FT /note="28"
FT REPEAT 244..245
FT /note="29"
FT REPEAT 252..253
FT /note="30"
FT REPEAT 260..261
FT /note="31"
FT REPEAT 268..269
FT /note="32"
FT REPEAT 276..277
FT /note="33"
FT REPEAT 284..285
FT /note="34"
FT REPEAT 294..295
FT /note="35"
FT REPEAT 300..301
FT /note="36"
FT REPEAT 307..308
FT /note="37"
FT REPEAT 312..313
FT /note="38"
FT REPEAT 319..320
FT /note="39"
FT REPEAT 329..330
FT /note="40"
FT REPEAT 334..335
FT /note="41"
FT REPEAT 339..340
FT /note="42"
FT REPEAT 411..412
FT /note="43"
FT REPEAT 427..428
FT /note="44"
FT REPEAT 459..460
FT /note="45"
FT REPEAT 466..467
FT /note="46"
FT REPEAT 471..472
FT /note="47"
FT REPEAT 480..481
FT /note="48"
FT REPEAT 491..492
FT /note="49"
FT REPEAT 497..498
FT /note="50"
FT REPEAT 506..507
FT /note="51"
FT REPEAT 514..515
FT /note="52"
FT REPEAT 521..522
FT /note="53"
FT REPEAT 533..534
FT /note="54"
FT REPEAT 555..556
FT /note="55"
FT REPEAT 562..563
FT /note="56"
FT REPEAT 565..566
FT /note="57"
FT REPEAT 573..574
FT /note="58"
FT REPEAT 586..587
FT /note="59"
FT REPEAT 604..605
FT /note="60"
FT REPEAT 627..628
FT /note="61"
FT REPEAT 632..633
FT /note="62"
FT REPEAT 650..651
FT /note="63"
FT REPEAT 655..656
FT /note="64"
FT REPEAT 676..677
FT /note="65"
FT DOMAIN 885..1027
FT /note="Peptidase S59"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00765"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2..677
FT /note="65 X 2 AA repeats of F-G"
FT REGION 98..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 734..860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 829..844
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..859
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1041 AA; 106308 MW; 436DFBBC21E11CB9 CRC64;
MFGSSNPFGQ SSGTSPFGSQ SLFGQTSNTS SNNPFAPATP FGTSAPFAAQ SGSSIFGSTS
TGVFGAPQTS SPFASTPTFG ASSSPAFGNS TPAFGASPAS SPFGGSSGFG QKPLGFSTPQ
SNPFGNSTQQ SQPAFGNTSF GSSTPFGATN TPAFGAPSTP SFGATSTPSF GASSTPAFGA
TNTPAFGASN SPSFGATNTP AFGASPTPAF GSTGTTFGNT GFGSGGAFGA SNTPAFGASG
TPAFGASGTP AFGASSTPAF GASSTPAFGA SSTPAFGGSS TPSFGASNTS SFSFGSSPAF
GQSTSAFGSS AFGSTPSPFG GAQASTPTFG GSGFGQSTFG GQQGGSRAVP YAPTVEADTG
TGTQPAGKLE SISAMPAYKE KNYEELRWED YQRGDKGGPL PAGQSPGNAG FGISPSQPNP
FSPSPAFGQT SANPTNPFSS STSTNPFAPQ TPTIASSSFG TATSNFGSSP FGVTSSSNLF
GSGSSTTTSV FGSSSAFGTT TPSPLFGSSS TPGFGSSSSI FGSAPGQGAT PAFGNSQPST
LFNSTPSTGQ TGSAFGQTGS AFGQFGQSSA PAFGQNSIFN KPSTGFGNMF SSSSTLTTSS
SSPFGQTMPA GVTPFQSAQP GQASNGFGFN NFGQNQAANT TGNAGGLGIF GQGNFGQSPA
PLNSVVLQPV AVTNPFGTLP AMPQISINQG GNSPSIQYGI SSMPVVDKPA PVRISSLLTS
RHLLHRRVRL PARKYRPGEN GPKVPFFTDD EESSSTPKAD ALFIPRENPR ALVIRPVQQW
SSRDKSILPK EQRPTAPLHD NGKSPDMATD AANHDRNGNG ELGATGERIH TSVNANQKPN
GTTRSDQASE KERPYKTLSG HRAGEAAIVY EHGADIEALM PKLRQSDYFT EPRIQELAAK
ERADPGYCRR VRDFVVGRHG YGSIKFMGET DVRRLDLESL VQFNTREVIV YMDESKKPAV
GQGLNKPAEV TLLNIKCIDK KTGKQFTEGE RVEKYKMMLK KKAEAQGAEF VSFDPVKGEW
KFRVEHFSSY KLGDEDEEDG V
