NU98B_ARATH
ID NU98B_ARATH Reviewed; 997 AA.
AC F4ID16; Q9LQ50;
DT 26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Nuclear pore complex protein NUP98B {ECO:0000303|PubMed:21189294};
DE AltName: Full=Nucleoporin 98B {ECO:0000303|PubMed:21189294};
DE AltName: Full=Nucleoporin autopeptidase {ECO:0000312|EMBL:AEE33600.1};
GN Name=NUP98B {ECO:0000303|PubMed:21189294};
GN OrderedLocusNames=At1g59660 {ECO:0000312|Araport:AT1G59660};
GN ORFNames=T30E16.23 {ECO:0000312|EMBL:AAF79757.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP IDENTIFICATION IN THE NUCLEAR PORE COMPLEX BY MASS SPECTROMETRY, AND
RP NOMENCLATURE.
RX PubMed=21189294; DOI=10.1105/tpc.110.079947;
RA Tamura K., Fukao Y., Iwamoto M., Haraguchi T., Hara-Nishimura I.;
RT "Identification and characterization of nuclear pore complex components in
RT Arabidopsis thaliana.";
RL Plant Cell 22:4084-4097(2010).
CC -!- SUBUNIT: Part of the nuclear pore complex (NPC). The NPC has an eight-
CC fold symmetrical structure comprising a central transport channel and
CC two rings, the cytoplasmic and nuclear rings, to which eight filaments
CC are attached. The cytoplasmic filaments have loose ends, while the
CC nuclear filaments are joined in a distal ring, forming a nuclear
CC basket. NPCs are highly dynamic in configuration and composition, and
CC can be devided in 3 subcomplexes, the NUP62 subcomplex, the NUP107-160
CC subcomplex and the NUP93 subcomplex, containing approximately 30
CC different nucleoporin proteins. {ECO:0000305|PubMed:21189294}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC {ECO:0000305|PubMed:21189294}.
CC -!- DOMAIN: Contains FG repeats mediating the translocation through the NPC
CC by interacting with transport factors. {ECO:0000305}.
CC -!- MISCELLANEOUS: Unlike in mammals and yeast, NUP96 and NUP98 are not
CC translated as a polyprotein. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the nucleoporin GLFG family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF79757.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC009317; AAF79757.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE33600.1; -; Genomic_DNA.
DR PIR; C96620; C96620.
DR RefSeq; NP_176175.1; NM_104659.3.
DR AlphaFoldDB; F4ID16; -.
DR BioGRID; 27481; 4.
DR STRING; 3702.AT1G59660.1; -.
DR MEROPS; S59.A03; -.
DR PaxDb; F4ID16; -.
DR PRIDE; F4ID16; -.
DR EnsemblPlants; AT1G59660.1; AT1G59660.1; AT1G59660.
DR GeneID; 842256; -.
DR Gramene; AT1G59660.1; AT1G59660.1; AT1G59660.
DR KEGG; ath:AT1G59660; -.
DR Araport; AT1G59660; -.
DR TAIR; locus:2202887; AT1G59660.
DR eggNOG; KOG0845; Eukaryota.
DR HOGENOM; CLU_012217_0_0_1; -.
DR InParanoid; F4ID16; -.
DR OMA; QPTNPFG; -.
DR OrthoDB; 93359at2759; -.
DR PRO; PR:F4ID16; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4ID16; baseline and differential.
DR Genevisible; F4ID16; AT.
DR GO; GO:0005635; C:nuclear envelope; IDA:TAIR.
DR GO; GO:0044614; C:nuclear pore cytoplasmic filaments; IBA:GO_Central.
DR GO; GO:0017056; F:structural constituent of nuclear pore; IBA:GO_Central.
DR GO; GO:0071456; P:cellular response to hypoxia; HEP:TAIR.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0048573; P:photoperiodism, flowering; IGI:TAIR.
DR GO; GO:0000973; P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery; IBA:GO_Central.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR GO; GO:0006405; P:RNA export from nucleus; IBA:GO_Central.
DR Gene3D; 3.30.1610.10; -; 1.
DR InterPro; IPR037665; Nucleoporin_S59-like.
DR InterPro; IPR007230; Nup98_auto-Pept-S59_dom.
DR InterPro; IPR036903; Nup98_auto-Pept-S59_dom_sf.
DR PANTHER; PTHR23198; PTHR23198; 2.
DR Pfam; PF04096; Nucleoporin2; 1.
DR SUPFAM; SSF82215; SSF82215; 1.
DR PROSITE; PS51434; NUP_C; 1.
PE 1: Evidence at protein level;
KW mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW Reference proteome; Repeat; Translocation; Transport.
FT CHAIN 1..997
FT /note="Nuclear pore complex protein NUP98B"
FT /id="PRO_0000431087"
FT REPEAT 2..3
FT /note="1"
FT REPEAT 10..11
FT /note="2"
FT REPEAT 19..20
FT /note="3"
FT REPEAT 27..28
FT /note="4"
FT REPEAT 44..45
FT /note="5"
FT REPEAT 50..51
FT /note="6"
FT REPEAT 59..60
FT /note="7"
FT REPEAT 67..68
FT /note="8"
FT REPEAT 76..77
FT /note="9"
FT REPEAT 83..84
FT /note="10"
FT REPEAT 90..91
FT /note="11"
FT REPEAT 98..99
FT /note="12"
FT REPEAT 105..106
FT /note="13"
FT REPEAT 111..112
FT /note="14"
FT REPEAT 116..117
FT /note="15"
FT REPEAT 126..127
FT /note="16"
FT REPEAT 137..138
FT /note="17"
FT REPEAT 142..143
FT /note="18"
FT REPEAT 148..149
FT /note="19"
FT REPEAT 156..157
FT /note="20"
FT REPEAT 164..165
FT /note="21"
FT REPEAT 172..173
FT /note="22"
FT REPEAT 180..181
FT /note="23"
FT REPEAT 188..189
FT /note="24"
FT REPEAT 196..197
FT /note="25"
FT REPEAT 204..205
FT /note="26"
FT REPEAT 212..213
FT /note="27"
FT REPEAT 220..221
FT /note="28"
FT REPEAT 228..229
FT /note="29"
FT REPEAT 236..237
FT /note="30"
FT REPEAT 243..244
FT /note="31"
FT REPEAT 254..255
FT /note="32"
FT REPEAT 262..263
FT /note="33"
FT REPEAT 270..271
FT /note="34"
FT REPEAT 280..281
FT /note="35"
FT REPEAT 286..287
FT /note="36"
FT REPEAT 293..294
FT /note="37"
FT REPEAT 298..299
FT /note="38"
FT REPEAT 312..313
FT /note="39"
FT REPEAT 324..325
FT /note="40"
FT REPEAT 401..402
FT /note="41"
FT REPEAT 451..452
FT /note="42"
FT REPEAT 470..471
FT /note="43"
FT REPEAT 489..490
FT /note="44"
FT REPEAT 515..516
FT /note="45"
FT REPEAT 536..537
FT /note="46"
FT REPEAT 551..552
FT /note="47"
FT REPEAT 572..573
FT /note="48"
FT REPEAT 589..590
FT /note="49"
FT REPEAT 611..612
FT /note="50"
FT REPEAT 616..617
FT /note="51"
FT REPEAT 660..661
FT /note="52"
FT DOMAIN 844..986
FT /note="Peptidase S59"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00765"
FT REGION 1..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2..661
FT /note="52 X 2 AA repeats of F-G"
FT REGION 293..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 714..744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 758..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..386
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..552
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..731
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 758..775
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..794
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 997 AA; 103372 MW; 741993142602E44A CRC64;
MFGSSNNNPF GQSSISSPFG TQTHSLFGQT NNNASNNPFA TKPFGTSTPF GAQTGSSMFG
GTSTGVFGAP QTSSPFGASP QAFGSSTQAF GASSTPSFGS SNSPFGGTST FGQKSFGLST
PQSSPFGSTT QQSQPAFGNS TFGSSTPFGA STTPAFGASS TPAFGVSNTS GFGATNTPGF
GATNTTGFGG SSTPGFGASS TPAFGSTNTP AFGASSTPLF GSSSSPAFGA SPAPAFGSSG
NAFGNNTFSS GGAFGSSSTP TFGASNTSAF GASSSPSFNF GSSPAFGQST SAFGSSSFGS
TQSSLGSTPS PFGAQGAQAS TSTFGGQSTI GGQQGGSRVI PYAPTTDTAS GTESKSERLQ
SISAMPAHKG KNMEELRWED YQRGDKGGQR STGQSPEGAG FGVTNSQPSI FSTSPAFSQT
PVNPTNPFSQ TTPTSNTNFS PSFSQPTTPS FGQPTTPSFR STVSNTTSVF GSSSSLTTNT
SQPLGSSIFG STPAHGSTPG FSIGGFNNSQ SSPLFGSNPS FAQNTTPAFS QTSPLFGQNT
TPALGQSSSV FGQNTNPALV QSNTFSTPST GFGNTFSSSS SLTTSISPFG QITPAVTPFQ
SAQPTQPLGA FGFNNFGQTQ IANTTDIAGA MGTFSQGNFK QQPALGNSAV MQPTPVTNPF
GTLPALPQIS IAQGGNSPSI QYGISSMPVV DKPAPVRVSP LLTSRHLLQR RVRLPTRKYR
PSDDGPKVPF FSDEEENSST PKADAFFIPR ENPRALFIRP VERVKSEHPK DSPTPLQENG
KRSNGVTNGA NHETKDNGAI REAPPVKVNQ KQNGTHENHG GDKNGSHSSP SGADIESLMP
KLHHSEYFTE PRIQELAAKE RVEQGYCKRV KDFVVGRHGY GSIKFLGETD VCRLDLEMVV
QFKNREVNVY MDESKKPPVG QGLNKPAVVT LLNIKCMDKK TGTQVMEGER LDKYKEMLKR
KAGEQGAQFV SYDPVNGEWT FKVEHFSSYK LGDEYDV
