NUA4L_HUMAN
ID NUA4L_HUMAN Reviewed; 87 AA.
AC Q9NRX3; Q6IAH9;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2;
DE AltName: Full=NADH-ubiquinone oxidoreductase MLRQ subunit homolog;
DE Short=NUOMS;
GN Name=NDUFA4L2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Adrenal gland;
RX PubMed=10931946; DOI=10.1073/pnas.160270997;
RA Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X.,
RA Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W.,
RA Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., Xu S.-H., Gu J.,
RA Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z.,
RA Chen M.-D., Chen J.-L.;
RT "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis
RT and full-length cDNA cloning.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the complex I NDUFA4 subunit family.
CC {ECO:0000305}.
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DR EMBL; AF164796; AAF80760.1; -; mRNA.
DR EMBL; CR457176; CAG33457.1; -; mRNA.
DR EMBL; BC011910; AAH11910.1; -; mRNA.
DR CCDS; CCDS8935.1; -.
DR RefSeq; NP_064527.1; NM_020142.3.
DR AlphaFoldDB; Q9NRX3; -.
DR SMR; Q9NRX3; -.
DR BioGRID; 121231; 23.
DR IntAct; Q9NRX3; 19.
DR MINT; Q9NRX3; -.
DR STRING; 9606.ENSP00000377411; -.
DR BindingDB; Q9NRX3; -.
DR ChEMBL; CHEMBL2363065; -.
DR DrugBank; DB00157; NADH.
DR DrugCentral; Q9NRX3; -.
DR iPTMnet; Q9NRX3; -.
DR PhosphoSitePlus; Q9NRX3; -.
DR BioMuta; NDUFA4L2; -.
DR DMDM; 23396790; -.
DR MassIVE; Q9NRX3; -.
DR MaxQB; Q9NRX3; -.
DR PaxDb; Q9NRX3; -.
DR PeptideAtlas; Q9NRX3; -.
DR PRIDE; Q9NRX3; -.
DR ProteomicsDB; 82434; -.
DR Antibodypedia; 43977; 156 antibodies from 23 providers.
DR DNASU; 56901; -.
DR Ensembl; ENST00000393825.5; ENSP00000377411.1; ENSG00000185633.11.
DR Ensembl; ENST00000554503.6; ENSP00000450664.1; ENSG00000185633.11.
DR GeneID; 56901; -.
DR KEGG; hsa:56901; -.
DR MANE-Select; ENST00000554503.6; ENSP00000450664.1; NM_001394961.1; NP_001381890.1.
DR UCSC; uc001sno.4; human.
DR CTD; 56901; -.
DR DisGeNET; 56901; -.
DR GeneCards; NDUFA4L2; -.
DR HGNC; HGNC:29836; NDUFA4L2.
DR HPA; ENSG00000185633; Tissue enhanced (esophagus).
DR neXtProt; NX_Q9NRX3; -.
DR OpenTargets; ENSG00000185633; -.
DR PharmGKB; PA144596402; -.
DR VEuPathDB; HostDB:ENSG00000185633; -.
DR eggNOG; ENOG502SG4Q; Eukaryota.
DR GeneTree; ENSGT00940000161040; -.
DR HOGENOM; CLU_181002_0_0_1; -.
DR InParanoid; Q9NRX3; -.
DR OMA; PSYQYKF; -.
DR OrthoDB; 1552648at2759; -.
DR PhylomeDB; Q9NRX3; -.
DR TreeFam; TF106383; -.
DR BioCyc; MetaCyc:G66-33023-MON; -.
DR PathwayCommons; Q9NRX3; -.
DR SignaLink; Q9NRX3; -.
DR BioGRID-ORCS; 56901; 12 hits in 1078 CRISPR screens.
DR ChiTaRS; NDUFA4L2; human.
DR GenomeRNAi; 56901; -.
DR Pharos; Q9NRX3; Tclin.
DR PRO; PR:Q9NRX3; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q9NRX3; protein.
DR Bgee; ENSG00000185633; Expressed in lower esophagus mucosa and 148 other tissues.
DR ExpressionAtlas; Q9NRX3; baseline and differential.
DR Genevisible; Q9NRX3; HS.
DR GO; GO:0005751; C:mitochondrial respiratory chain complex IV; IBA:GO_Central.
DR InterPro; IPR010530; B12D.
DR PANTHER; PTHR14256; PTHR14256; 1.
DR Pfam; PF06522; B12D; 1.
PE 3: Inferred from homology;
KW Reference proteome.
FT CHAIN 1..87
FT /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
FT subunit 4-like 2"
FT /id="PRO_0000118825"
SQ SEQUENCE 87 AA; 9966 MW; A08D7182A0A3CA87 CRC64;
MAGASLGARF YRQIKRHPGI IPMIGLICLG MGSAALYLLR LALRSPDVCW DRKNNPEPWN
RLSPNDQYKF LAVSTDYKKL KKDRPDF
