NUC1_NEUCR
ID NUC1_NEUCR Reviewed; 801 AA.
AC P20824; Q7SD79;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 19-MAR-2014, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Phosphorus acquisition-controlling protein;
GN Name=nuc-1; ORFNames=NCU09315;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 18889 / 74-OR8-1a / 40-21 / DSM 1258 / FGSC 988;
RX PubMed=2146493; DOI=10.1128/mcb.10.11.5839-5848.1990;
RA Kang S., Metzenberg R.L.;
RT "Molecular analysis of nuc-1+, a gene controlling phosphorus acquisition in
RT Neurospora crassa.";
RL Mol. Cell. Biol. 10:5839-5848(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Factor that activates the transcription of structural genes
CC for phosphorus acquisition.
CC -!- SUBUNIT: Binds DNA as a dimer.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA33603.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; M37700; AAA33603.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CM002236; EAA34721.2; -; Genomic_DNA.
DR PIR; A36378; A36378.
DR RefSeq; XP_963957.2; XM_958864.2.
DR AlphaFoldDB; P20824; -.
DR SMR; P20824; -.
DR STRING; 367110.P20824; -.
DR EnsemblFungi; EAA34721; EAA34721; NCU09315.
DR GeneID; 3880106; -.
DR KEGG; ncr:NCU09315; -.
DR VEuPathDB; FungiDB:NCU09315; -.
DR HOGENOM; CLU_015973_1_0_1; -.
DR InParanoid; P20824; -.
DR Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..801
FT /note="Phosphorus acquisition-controlling protein"
FT /id="PRO_0000127410"
FT DOMAIN 645..735
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 292..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 446..540
FT /note="Interaction with negative regulatory factor"
FT /evidence="ECO:0000255"
FT REGION 628..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..424
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..538
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..588
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..649
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..715
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 142
FT /note="I -> V (in Ref. 1; AAA33603)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 801 AA; 84839 MW; 13D0B6FC69582474 CRC64;
MNSSSWSAPD HSHHPALHTA ADDDFHQYLD INDMGDLSDA LDFDFRDFGA DHHTAPHAGR
HAADHLLHPS GGEHLDTPMT GTDMSMILSP VDHAMLRHGV QQQQHHQQQQ HQQHQMPTIT
TTAPYQNAPT ALIQPSTPSE AIVNTIDAQI QFLQQQKLHA QHQQLQEQQA AFFASQQNHI
VPPTPQSLEL TAGSSQNYYA QSTLSDQHHS GPQKQQQPQQ AIDYRYTRIK DQHDMSFTPL
VSPAVTPLET HFPIDTPFAV PGAYFSPLTS PALHAQNDAL GIIDQRLGMM SGSSPREMEL
EPPAMSQASV SPGDLARKTR KNAVKARAKS GSGIKQSPIS KPIRRKTATT PMLNPQALNQ
LVENAAPSQE RQQPLTPLIP TSSSSTAGVT DSENGSISPE NLNDVVLPVE MPPPPLPKPR
SAKPSPFLAP QASGSAVPIN LQPGRPGIAS PATPASLMKL SSPSNRNPSV VGTGSHDPMD
PDHIENFELP DSINFSSAPK PAPIITTLGT PALDPLQKAA APLQTPGLPP PPSPAVAKPL
ALPSAALSSP QLKPDSAHSL KRTPQLAPMG RSSKKRASVT SIQMSPALRP KISPSIKPLL
PGGSAGAEDA ASILLATKSN YQRILEGNTV PGVSYPSELS TNLTSKRTSH KIAEQGRRNR
INSALQEIAT LLPKAPAKEG GDGDGDGHSS SGGGGGSGGA DREDKREKDK DKAGGGIPNS
KASTVEMAIE YIKQLQKEVA DANKRAEEAE RKLVEMKMQG GAATGSGSSV GDAGDLGTPT
TEANPVVDED LKSGGGDAMD E
