ID   NUCL2_ORYSJ             Reviewed;         707 AA.
AC   Q7XTT4; A0A0P0WEX5;
DT   16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2004, sequence version 2.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Nucleolin 2;
DE   AltName: Full=Protein NUCLEOLIN LIKE 2;
GN   OrderedLocusNames=Os04g0620700, LOC_Os04g52960; ORFNames=OSJNBa0058K23.21;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12447439; DOI=10.1038/nature01183;
RA   Feng Q., Zhang Y., Hao P., Wang S., Fu G., Huang Y., Li Y., Zhu J., Liu Y.,
RA   Hu X., Jia P., Zhang Y., Zhao Q., Ying K., Yu S., Tang Y., Weng Q.,
RA   Zhang L., Lu Y., Mu J., Lu Y., Zhang L.S., Yu Z., Fan D., Liu X., Lu T.,
RA   Li C., Wu Y., Sun T., Lei H., Li T., Hu H., Guan J., Wu M., Zhang R.,
RA   Zhou B., Chen Z., Chen L., Jin Z., Wang R., Yin H., Cai Z., Ren S., Lv G.,
RA   Gu W., Zhu G., Tu Y., Jia J., Zhang Y., Chen J., Kang H., Chen X., Shao C.,
RA   Sun Y., Hu Q., Zhang X., Zhang W., Wang L., Ding C., Sheng H., Gu J.,
RA   Chen S., Ni L., Zhu F., Chen W., Lan L., Lai Y., Cheng Z., Gu M., Jiang J.,
RA   Li J., Hong G., Xue Y., Han B.;
RT   "Sequence and analysis of rice chromosome 4.";
RL   Nature 420:316-320(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- FUNCTION: Involved in pre-rRNA processing and ribosome assembly.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
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DR   EMBL; AL662970; CAD41755.2; -; Genomic_DNA.
DR   EMBL; AP008210; BAF15823.1; -; Genomic_DNA.
DR   EMBL; AP014960; BAS91061.1; -; Genomic_DNA.
DR   EMBL; AK103446; BAG96085.1; -; mRNA.
DR   RefSeq; XP_015636765.1; XM_015781279.1.
DR   AlphaFoldDB; Q7XTT4; -.
DR   SMR; Q7XTT4; -.
DR   STRING; 4530.OS04T0620700-01; -.
DR   PaxDb; Q7XTT4; -.
DR   PRIDE; Q7XTT4; -.
DR   EnsemblPlants; Os04t0620700-01; Os04t0620700-01; Os04g0620700.
DR   GeneID; 4337032; -.
DR   Gramene; Os04t0620700-01; Os04t0620700-01; Os04g0620700.
DR   KEGG; osa:4337032; -.
DR   eggNOG; KOG4210; Eukaryota.
DR   HOGENOM; CLU_030920_1_0_1; -.
DR   InParanoid; Q7XTT4; -.
DR   OMA; DIHQIRN; -.
DR   OrthoDB; 1202220at2759; -.
DR   Proteomes; UP000000763; Chromosome 4.
DR   Proteomes; UP000059680; Chromosome 4.
DR   ExpressionAtlas; Q7XTT4; baseline and differential.
DR   Genevisible; Q7XTT4; OS.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd12450; RRM1_NUCLs; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR034349; NUCL_RRM1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 2.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 2.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repeat; RNA-binding; rRNA processing.
FT   CHAIN           1..707
FT                   /note="Nucleolin 2"
FT                   /id="PRO_0000417404"
FT   DOMAIN          449..525
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          549..630
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          1..446
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          527..546
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          629..707
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..77
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..111
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        230..250
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        260..274
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        285..314
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        334..348
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        416..446
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        532..546
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        656..683
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   707 AA;  75253 MW;  F822FF80CAA8F21B CRC64;
     MGKSSKKSAV EVAPTSVSVS EGKSGKKGKR NAEDEIEKAV SAKKQKTVRE KVVPSKEEAK
     KVKKQPPPKK VESSSSEEDS SESEEEVKAQ PKKTVQPKKA AQPAKEESSD DSSDDSSSDD
     EPAKKPVARP NKAALSTNSS SSDDSSDESL SDDEPVKKPA APLKKPVALA TNGSKKVETD
     SSSSDSSSDE ESDEDDKKTA APVKKPSVAA IQKKTQESDS SDSDSDSESD EDVPTKAPAV
     AKKKEESSES SDSESDSDSD DEAAAVKKEE ESSDSSDSDS ESESDSDEPA KPTIPAKRPL
     TKDTKKGQSK DESEDSSDES SEESGDEPPQ KKIKDSTTSG TTKPSPKATK KEISSDDESD
     EDDSSDESSD EDVKQKQTQA KKQAPVAQES SSSDESSEED SDMESDEPAK TPQKKETAVS
     VGSNKSATKP GQEEPKTPAS NQNQATGSKT LFVGNLPYNV EQEQVKQFFQ EAGEVVDIRF
     STFEDGNFRG FGHVEFATAE AAKKALELAG HDLMGRPVRL DLARERGAYT PGSGRDNSSF
     KKPAQSSGNT IFIKGFDTSL DIHQIRNSLE EHFGSCGEIT RVSIPKDYET GASKGMAYMD
     FADNGSLSKA YELNGSDLGG YSLYVDEARP RPDNNREGGF SGGRDFNSSG RGGRRGGRGD
     GSRGRGDRGR GRGFGRGDRG HGGRGTPFKQ SAGTPSAGKK TTFGDDD