NUCM_DICD3
ID NUCM_DICD3 Reviewed; 232 AA.
AC P37994; E0SH59;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Nuclease NucM;
DE EC=3.1.21.-;
DE Flags: Precursor;
GN Name=nucM; OrderedLocusNames=Dda3937_00422;
OS Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Pectobacteriaceae; Dickeya.
OX NCBI_TaxID=198628;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=3937;
RX PubMed=8332061; DOI=10.1111/j.1365-2958.1993.tb01612.x;
RA Moulard M., Condemine G., Robert-Baudouy J.;
RT "Characterization of the nucM gene coding for a nuclease of the
RT phytopathogenic bacteria Erwinia chrysanthemi.";
RL Mol. Microbiol. 8:685-695(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3937;
RX PubMed=21217001; DOI=10.1128/jb.01513-10;
RA Glasner J.D., Yang C.H., Reverchon S., Hugouvieux-Cotte-Pattat N.,
RA Condemine G., Bohin J.P., Van Gijsegem F., Yang S., Franza T., Expert D.,
RA Plunkett G. III, San Francisco M.J., Charkowski A.O., Py B., Bell K.,
RA Rauscher L., Rodriguez-Palenzuela P., Toussaint A., Holeva M.C., He S.Y.,
RA Douet V., Boccara M., Blanco C., Toth I., Anderson B.D., Biehl B.S.,
RA Mau B., Flynn S.M., Barras F., Lindeberg M., Birch P.R., Tsuyumu S.,
RA Shi X., Hibbing M., Yap M.N., Carpentier M., Dassa E., Umehara M.,
RA Kim J.F., Rusch M., Soni P., Mayhew G.F., Fouts D.E., Gill S.R.,
RA Blattner F.R., Keen N.T., Perna N.T.;
RT "Genome sequence of the plant-pathogenic bacterium Dickeya dadantii 3937.";
RL J. Bacteriol. 193:2076-2077(2011).
CC -!- FUNCTION: May protect the bacterium against the invasion of foreign
CC DNA. It may have a random endonucleolytic activity. May be implicated
CC as well in pathogenicity.
CC -!- SUBCELLULAR LOCATION: Periplasm.
CC -!- DEVELOPMENTAL STAGE: Expressed constitutively.
CC -!- SIMILARITY: Belongs to the EndA/NucM nuclease family. {ECO:0000305}.
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DR EMBL; X73255; CAA51713.1; -; Genomic_DNA.
DR EMBL; CP002038; ADN00152.1; -; Genomic_DNA.
DR PIR; S34943; S34943.
DR RefSeq; WP_013319571.1; NC_014500.1.
DR AlphaFoldDB; P37994; -.
DR SMR; P37994; -.
DR STRING; 198628.Dda3937_00422; -.
DR EnsemblBacteria; ADN00152; ADN00152; Dda3937_00422.
DR GeneID; 9735431; -.
DR KEGG; ddd:Dda3937_00422; -.
DR PATRIC; fig|198628.6.peg.3894; -.
DR eggNOG; COG2356; Bacteria.
DR HOGENOM; CLU_070541_0_0_6; -.
DR OMA; ADQYGQC; -.
DR OrthoDB; 1114630at2; -.
DR BioCyc; DDAD198628:DDA3937_RS18550-MON; -.
DR Proteomes; UP000006859; Chromosome.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR InterPro; IPR007346; Endonuclease-I.
DR InterPro; IPR044925; His-Me_finger_sf.
DR PANTHER; PTHR33607; PTHR33607; 1.
DR Pfam; PF04231; Endonuclease_1; 1.
DR SUPFAM; SSF54060; SSF54060; 1.
PE 2: Evidence at transcript level;
KW Endonuclease; Hydrolase; Nuclease; Periplasm; Reference proteome; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..232
FT /note="Nuclease NucM"
FT /id="PRO_0000007828"
FT CONFLICT 231..232
FT /note="QP -> SPDAAPYYNGLSLIMIAAVATVAARWLTPAGHLPSD (in Ref.
FT 1; CAA51713)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 232 AA; 26456 MW; 30C33AC6B87A1073 CRC64;
MLRNLVIFAV LGAGLTTLAA AGQDINNFTQ AKAAAAKIHQ DAPGTFYCGC KINWQGKKGT
PDLASCGYQV RKDANRASRI EWEHVVPAWQ FGHQRQCWQD GGRKNCTKDD VYRQIETDLH
NLQPAIGEVN GDRGNFMYSQ WNGGERQYGQ CEMKIDFKSQ LAEPPERARG AIARTYFYMR
DRYNLNLSRQ QTQLFDAWNK QYPATTWECT REKRIAAVQG NHNPYVQQAC QP
