NUCS_FRAAA
ID NUCS_FRAAA Reviewed; 220 AA.
AC Q0RDC6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=Endonuclease NucS {ECO:0000255|HAMAP-Rule:MF_00722};
DE EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00722};
GN Name=nucS {ECO:0000255|HAMAP-Rule:MF_00722}; OrderedLocusNames=FRAAL5919;
OS Frankia alni (strain ACN14a).
OC Bacteria; Actinobacteria; Frankiales; Frankiaceae; Frankia.
OX NCBI_TaxID=326424;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ACN14a;
RX PubMed=17151343; DOI=10.1101/gr.5798407;
RA Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A.,
RA Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P.,
RA Goltsman E., Huang Y., Kopp O.R., Labarre L., Lapidus A., Lavire C.,
RA Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J.,
RA Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F.,
RA Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C.,
RA Benson D.R.;
RT "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT reflect host range and host plant biogeography.";
RL Genome Res. 17:7-15(2007).
CC -!- FUNCTION: Cleaves both 3' and 5' ssDNA extremities of branched DNA
CC structures. {ECO:0000255|HAMAP-Rule:MF_00722}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00722}.
CC -!- SIMILARITY: Belongs to the NucS endonuclease family.
CC {ECO:0000255|HAMAP-Rule:MF_00722}.
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DR EMBL; CT573213; CAJ64544.1; -; Genomic_DNA.
DR RefSeq; WP_011606979.1; NC_008278.1.
DR AlphaFoldDB; Q0RDC6; -.
DR SMR; Q0RDC6; -.
DR STRING; 326424.FRAAL5919; -.
DR KEGG; fal:FRAAL5919; -.
DR eggNOG; COG1637; Bacteria.
DR HOGENOM; CLU_069350_0_0_11; -.
DR OMA; RCSVDYA; -.
DR OrthoDB; 1002946at2; -.
DR Proteomes; UP000000657; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000014; F:single-stranded DNA endodeoxyribonuclease activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1350.10; -; 1.
DR HAMAP; MF_00722; NucS; 1.
DR InterPro; IPR002793; Endonuclease_NucS.
DR InterPro; IPR011856; tRNA_endonuc-like_dom_sf.
DR PANTHER; PTHR38814; PTHR38814; 1.
DR Pfam; PF01939; NucS; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; Endonuclease; Hydrolase; Nuclease;
KW Reference proteome.
FT CHAIN 1..220
FT /note="Endonuclease NucS"
FT /id="PRO_1000045830"
SQ SEQUENCE 220 AA; 23846 MW; BDBCC7C95DE8D314 CRC64;
MRLVIARCSV DYVGRLTAHL PSAVRLVLVK ADGSVSIHAD GRAYKPLNWM SPPCVIAEES
GVWRVTNKAA EQLVITLEEI LHDSSHELGV DPGLRKDGVE AHLQVLLADR PDAIAPGLTL
IRREYETGIG PVDLLCRDSD GSTVAVEIKR KGEIDGVEQL TRYLVRLDAD PALPHPVRGI
LAAQSITPQA RLLAADRGLG CAVVDYDELR GLEPSIPTLF