NUCS_MYCA9
ID NUCS_MYCA9 Reviewed; 232 AA.
AC B1MLW9;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Endonuclease NucS {ECO:0000255|HAMAP-Rule:MF_00722};
DE EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00722};
GN Name=nucS {ECO:0000255|HAMAP-Rule:MF_00722}; OrderedLocusNames=MAB_1460;
OS Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM
OS 13569 / NCTC 13031 / TMC 1543) (Mycobacterium abscessus).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacteroides; Mycobacteroides abscessus.
OX NCBI_TaxID=561007;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC
RC 1543;
RX PubMed=19543527; DOI=10.1371/journal.pone.0005660;
RA Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M.,
RA Macheras E., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L.,
RA Gaillard J.L.;
RT "Non mycobacterial virulence genes in the genome of the emerging pathogen
RT Mycobacterium abscessus.";
RL PLoS ONE 4:E5660-E5660(2009).
CC -!- FUNCTION: Cleaves both 3' and 5' ssDNA extremities of branched DNA
CC structures. {ECO:0000255|HAMAP-Rule:MF_00722}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00722}.
CC -!- SIMILARITY: Belongs to the NucS endonuclease family.
CC {ECO:0000255|HAMAP-Rule:MF_00722}.
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DR EMBL; CU458896; CAM61546.1; -; Genomic_DNA.
DR RefSeq; WP_005059861.1; NZ_MLCG01000002.1.
DR AlphaFoldDB; B1MLW9; -.
DR SMR; B1MLW9; -.
DR EnsemblBacteria; CAM61546; CAM61546; MAB_1460.
DR GeneID; 66971844; -.
DR KEGG; mab:MAB_1460; -.
DR OMA; RCSVDYA; -.
DR Proteomes; UP000007137; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000014; F:single-stranded DNA endodeoxyribonuclease activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1350.10; -; 1.
DR HAMAP; MF_00722; NucS; 1.
DR InterPro; IPR002793; Endonuclease_NucS.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR011856; tRNA_endonuc-like_dom_sf.
DR PANTHER; PTHR38814; PTHR38814; 1.
DR Pfam; PF01939; NucS; 1.
DR SUPFAM; SSF52980; SSF52980; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; Endonuclease; Hydrolase; Nuclease.
FT CHAIN 1..232
FT /note="Endonuclease NucS"
FT /id="PRO_1000198201"
SQ SEQUENCE 232 AA; 25523 MW; AFC2C4D93BF0CFC2 CRC64;
MRLVVAQCTV NYVGRLTAHL PSAKRLLLIK ADGSVSVHAD DRAYKPLNWM SPPCWLTETE
GEGGDDTSES GAPTVWVVEN KAGEQLRITI ESIEHDSAHE LGVDPGLVKD GVEAHLQELL
AEHVALLGDG YTLVRREYMT PIGPVDLLCR DADGATVAVE IKRRGEIDGV EQLTRYLELL
NRDTTLAPVA GVFAAQQIKP QARTLAEDRG IRCLTLDYDA MRGMDSDEFR LF