NUCS_MYCGI
ID NUCS_MYCGI Reviewed; 223 AA.
AC A4T8H8;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Endonuclease NucS {ECO:0000255|HAMAP-Rule:MF_00722};
DE EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00722};
GN Name=nucS {ECO:0000255|HAMAP-Rule:MF_00722}; OrderedLocusNames=Mflv_2337;
OS Mycolicibacterium gilvum (strain PYR-GCK) (Mycobacterium gilvum (strain
OS PYR-GCK)).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=350054;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PYR-GCK;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Miller C., Richardson P.;
RT "Complete sequence of chromosome of Mycobacterium gilvum PYR-GCK.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Cleaves both 3' and 5' ssDNA extremities of branched DNA
CC structures. {ECO:0000255|HAMAP-Rule:MF_00722}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00722}.
CC -!- SIMILARITY: Belongs to the NucS endonuclease family.
CC {ECO:0000255|HAMAP-Rule:MF_00722}.
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DR EMBL; CP000656; ABP44815.1; -; Genomic_DNA.
DR RefSeq; WP_011893218.1; NC_009338.1.
DR AlphaFoldDB; A4T8H8; -.
DR SMR; A4T8H8; -.
DR STRING; 350054.Mflv_2337; -.
DR EnsemblBacteria; ABP44815; ABP44815; Mflv_2337.
DR KEGG; mgi:Mflv_2337; -.
DR eggNOG; COG1637; Bacteria.
DR HOGENOM; CLU_069350_0_0_11; -.
DR OMA; RCSVDYA; -.
DR OrthoDB; 1002946at2; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000014; F:single-stranded DNA endodeoxyribonuclease activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1350.10; -; 1.
DR HAMAP; MF_00722; NucS; 1.
DR InterPro; IPR002793; Endonuclease_NucS.
DR InterPro; IPR011856; tRNA_endonuc-like_dom_sf.
DR PANTHER; PTHR38814; PTHR38814; 1.
DR Pfam; PF01939; NucS; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; Endonuclease; Hydrolase; Nuclease.
FT CHAIN 1..223
FT /note="Endonuclease NucS"
FT /id="PRO_1000083309"
SQ SEQUENCE 223 AA; 24887 MW; 78AD2DBCE8486326 CRC64;
MRLVIAQCTV DYVGRLTAHL PSARRLLLFK ADGSVSVHAD DRAYKPLNWM SPPCRLVEQA
DGETPVWVVE NKAGEQLRIT VEAIEHDSSH ELGVDPGLVK DGVEAHLQAL LAEHVELLGA
GYTLVRREYM TPIGPVDLLC RDEQGRSVAV EIKRRGEIDG VEQLTRYLEL LNRDSLLAPV
AGVFAAQQIK PQARTLATDR GIRCLTLDYD KMRGMDSDEF RLF