NUCS_MYCUA
ID NUCS_MYCUA Reviewed; 226 AA.
AC A0PUJ0;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Endonuclease NucS {ECO:0000255|HAMAP-Rule:MF_00722};
DE EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00722};
GN Name=nucS {ECO:0000255|HAMAP-Rule:MF_00722}; OrderedLocusNames=MUL_3940;
OS Mycobacterium ulcerans (strain Agy99).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=362242;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Agy99;
RX PubMed=17210928; DOI=10.1101/gr.5942807;
RA Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T.,
RA Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J.,
RA Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M.,
RA Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.;
RT "Reductive evolution and niche adaptation inferred from the genome of
RT Mycobacterium ulcerans, the causative agent of Buruli ulcer.";
RL Genome Res. 17:192-200(2007).
CC -!- FUNCTION: Cleaves both 3' and 5' ssDNA extremities of branched DNA
CC structures. {ECO:0000255|HAMAP-Rule:MF_00722}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00722}.
CC -!- SIMILARITY: Belongs to the NucS endonuclease family.
CC {ECO:0000255|HAMAP-Rule:MF_00722}.
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DR EMBL; CP000325; ABL06009.1; -; Genomic_DNA.
DR AlphaFoldDB; A0PUJ0; -.
DR SMR; A0PUJ0; -.
DR STRING; 362242.MUL_3940; -.
DR EnsemblBacteria; ABL06009; ABL06009; MUL_3940.
DR KEGG; mul:MUL_3940; -.
DR eggNOG; COG1637; Bacteria.
DR HOGENOM; CLU_069350_0_0_11; -.
DR OMA; RCSVDYA; -.
DR Proteomes; UP000000765; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000014; F:single-stranded DNA endodeoxyribonuclease activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1350.10; -; 1.
DR HAMAP; MF_00722; NucS; 1.
DR InterPro; IPR002793; Endonuclease_NucS.
DR InterPro; IPR011856; tRNA_endonuc-like_dom_sf.
DR PANTHER; PTHR38814; PTHR38814; 1.
DR Pfam; PF01939; NucS; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; Endonuclease; Hydrolase; Nuclease.
FT CHAIN 1..226
FT /note="Endonuclease NucS"
FT /id="PRO_1000198203"
SQ SEQUENCE 226 AA; 25178 MW; FE1534E18C19AC82 CRC64;
MIRVRLVIAQ CTVDYVGRLT AHLPSARRLL LFKADGSVSV HADDRAYKPL NWMSPPCWLT
EEPGGDSPVW VVTNKGGEQL RISVEEIEHD SSHELGVDPG LVKDGVEAHL QVLLAEHVQL
LGEGYTLVRR EYMTAIGPVD LLCRDESGGA VAVEIKRRGE IDGVEQLTRY LELLNRDSVL
APVKGVFAAQ QIKPQARTLA TDRGIRCVTL DYDKMRGMDS DEYRLF