ID   NUD14_BOVIN             Reviewed;         222 AA.
AC   Q05B60;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Uridine diphosphate glucose pyrophosphatase NUDT14;
DE            Short=UDPG pyrophosphatase;
DE            Short=UGPPase;
DE            EC=3.6.1.45;
DE   AltName: Full=Nucleoside diphosphate-linked moiety X motif 14;
DE            Short=Nudix motif 14;
GN   Name=NUDT14; Synonyms=UGPP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and
CC       ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate
CC       is probably UDP-glucose. Poor activity on other substrates such as ADP-
CC       glucose, CDP-glucose, GDP-glucose and GDP-mannose (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate.;
CC         EC=3.6.1.45;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Nudix hydrolase family. {ECO:0000305}.
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DR   EMBL; BC122769; AAI22770.1; -; mRNA.
DR   RefSeq; NP_001099122.1; NM_001105652.2.
DR   AlphaFoldDB; Q05B60; -.
DR   SMR; Q05B60; -.
DR   STRING; 9913.ENSBTAP00000055697; -.
DR   PaxDb; Q05B60; -.
DR   PRIDE; Q05B60; -.
DR   Ensembl; ENSBTAT00000063951; ENSBTAP00000055697; ENSBTAG00000048010.
DR   GeneID; 100126049; -.
DR   KEGG; bta:100126049; -.
DR   CTD; 256281; -.
DR   VEuPathDB; HostDB:ENSBTAG00000048010; -.
DR   VGNC; VGNC:32328; NUDT14.
DR   eggNOG; KOG4432; Eukaryota.
DR   GeneTree; ENSGT00940000154045; -.
DR   HOGENOM; CLU_062658_1_0_1; -.
DR   InParanoid; Q05B60; -.
DR   OMA; YTYELCA; -.
DR   OrthoDB; 1164318at2759; -.
DR   TreeFam; TF313661; -.
DR   Reactome; R-BTA-480985; Synthesis of dolichyl-phosphate-glucose.
DR   Proteomes; UP000009136; Chromosome 21.
DR   Bgee; ENSBTAG00000048010; Expressed in olfactory segment of nasal mucosa and 103 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0047631; F:ADP-ribose diphosphatase activity; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0008768; F:UDP-sugar diphosphatase activity; IBA:GO_Central.
DR   GO; GO:0006753; P:nucleoside phosphate metabolic process; IBA:GO_Central.
DR   GO; GO:0019693; P:ribose phosphate metabolic process; IBA:GO_Central.
DR   InterPro; IPR004385; NDP_pyrophosphatase.
DR   InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR   InterPro; IPR000086; NUDIX_hydrolase_dom.
DR   SUPFAM; SSF55811; SSF55811; 1.
DR   TIGRFAMs; TIGR00052; TIGR00052; 1.
DR   PROSITE; PS51462; NUDIX; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Hydrolase; Magnesium; Reference proteome.
FT   CHAIN           1..222
FT                   /note="Uridine diphosphate glucose pyrophosphatase NUDT14"
FT                   /id="PRO_0000282602"
FT   DOMAIN          38..206
FT                   /note="Nudix hydrolase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00794"
FT   MOTIF           111..129
FT                   /note="Nudix box"
SQ   SEQUENCE   222 AA;  23901 MW;  961622E27E0562D9 CRC64;
     MERIEGVAVG RCAASPYLVP LTLHYRQNGA QKSWDFMKTH DSVTILMFNS SRRSLVLVKQ
     FRPAVYAGEV ERLFPGSLAA AEQDRPQALQ AALPGSAGVT YELCAGLLDQ PGLSLEEVAC
     KEAWEECGYR LAPSDLRRVT SYKSGVGLTG SSQTMFYAEV TDAQRGSPGG GLAEEGELIE
     VVHLPLDGAR TFADDPDVPK TLGVIFGISW FFSCVAPGLG LQ