ID   NUD17_BOVIN             Reviewed;         302 AA.
AC   A4FUG7;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Nucleoside diphosphate-linked moiety X motif 17;
DE            Short=Nudix motif 17;
DE            EC=3.6.1.-;
GN   Name=NUDT17;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably mediates the hydrolysis of some nucleoside
CC       diphosphate derivatives. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the Nudix hydrolase family. {ECO:0000305}.
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DR   EMBL; BC114872; AAI14873.1; -; mRNA.
DR   RefSeq; NP_001076852.1; NM_001083383.2.
DR   AlphaFoldDB; A4FUG7; -.
DR   SMR; A4FUG7; -.
DR   STRING; 9913.ENSBTAP00000028830; -.
DR   PaxDb; A4FUG7; -.
DR   Ensembl; ENSBTAT00000028830; ENSBTAP00000028830; ENSBTAG00000021635.
DR   GeneID; 507315; -.
DR   KEGG; bta:507315; -.
DR   CTD; 200035; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021635; -.
DR   VGNC; VGNC:32332; NUDT17.
DR   eggNOG; ENOG502QWT5; Eukaryota.
DR   GeneTree; ENSGT00390000013847; -.
DR   HOGENOM; CLU_061877_1_0_1; -.
DR   InParanoid; A4FUG7; -.
DR   OMA; VSALMWL; -.
DR   OrthoDB; 1602447at2759; -.
DR   TreeFam; TF313611; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000021635; Expressed in laryngeal cartilage and 107 other tissues.
DR   GO; GO:0005777; C:peroxisome; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0035529; F:NADH pyrophosphatase activity; IBA:GO_Central.
DR   GO; GO:0019677; P:NAD catabolic process; IBA:GO_Central.
DR   GO; GO:0006734; P:NADH metabolic process; IBA:GO_Central.
DR   GO; GO:0006742; P:NADP catabolic process; IBA:GO_Central.
DR   CDD; cd04694; Nudix_Hydrolase_35; 1.
DR   InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR   InterPro; IPR000086; NUDIX_hydrolase_dom.
DR   InterPro; IPR033716; Nudt17_dom.
DR   Pfam; PF00293; NUDIX; 1.
DR   SUPFAM; SSF55811; SSF55811; 1.
DR   PROSITE; PS51462; NUDIX; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Magnesium; Manganese; Metal-binding; Reference proteome.
FT   CHAIN           1..302
FT                   /note="Nucleoside diphosphate-linked moiety X motif 17"
FT                   /id="PRO_0000380516"
FT   DOMAIN          89..237
FT                   /note="Nudix hydrolase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00794"
FT   MOTIF           128..149
FT                   /note="Nudix box"
FT   BINDING         143
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         147
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   302 AA;  32389 MW;  AD879288781F1016 CRC64;
     MAAARVLLLL SGRPESVSFA QSVCGLLGAG SGLGPWPTHC GLKRGQLVLS DKPFPGASAR
     LPLQRPPFCP FAALDQQPRA PGVELPPKGR GVDLGVAVIL QSSDQTVLLT RRTSTLNISP
     NLWVPPGGHV EPDEELLDGG LRELWEESGL QLPQGQFSWV PLGLWESAYP PKLSWGLPKY
     HHIVLYLLVI SQESQQQLQA RIQPNAGEVS AFMWLGPDIA AAVAATEDGT ETPKHLPQDL
     PSSVPTVELK ENGGAQPLAL PTSTLLRTTP GTADSRERVS TGTKFALTLW LQHLGRKSRD
     GS