ID   NUD17_DANRE             Reviewed;         300 AA.
AC   Q4V8V2;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Nucleoside diphosphate-linked moiety X motif 17;
DE            Short=Nudix motif 17;
DE            EC=3.6.1.-;
GN   Name=nudt17; ORFNames=zgc:114128;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably mediates the hydrolysis of some nucleoside
CC       diphosphate derivatives. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the Nudix hydrolase family. {ECO:0000305}.
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DR   EMBL; BC097186; AAH97186.1; -; mRNA.
DR   RefSeq; NP_001025274.1; NM_001030103.1.
DR   AlphaFoldDB; Q4V8V2; -.
DR   SMR; Q4V8V2; -.
DR   STRING; 7955.ENSDARP00000006375; -.
DR   PaxDb; Q4V8V2; -.
DR   GeneID; 556651; -.
DR   KEGG; dre:556651; -.
DR   CTD; 200035; -.
DR   ZFIN; ZDB-GENE-050913-50; nudt17.
DR   eggNOG; ENOG502QWT5; Eukaryota.
DR   InParanoid; Q4V8V2; -.
DR   PhylomeDB; Q4V8V2; -.
DR   PRO; PR:Q4V8V2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005777; C:peroxisome; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0035529; F:NADH pyrophosphatase activity; IBA:GO_Central.
DR   GO; GO:0019677; P:NAD catabolic process; IBA:GO_Central.
DR   GO; GO:0006734; P:NADH metabolic process; IBA:GO_Central.
DR   GO; GO:0006742; P:NADP catabolic process; IBA:GO_Central.
DR   CDD; cd04694; Nudix_Hydrolase_35; 1.
DR   InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR   InterPro; IPR000086; NUDIX_hydrolase_dom.
DR   InterPro; IPR033716; Nudt17_dom.
DR   Pfam; PF00293; NUDIX; 1.
DR   SUPFAM; SSF55811; SSF55811; 1.
DR   PROSITE; PS51462; NUDIX; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Magnesium; Manganese; Metal-binding; Reference proteome.
FT   CHAIN           1..300
FT                   /note="Nucleoside diphosphate-linked moiety X motif 17"
FT                   /id="PRO_0000380517"
FT   DOMAIN          88..239
FT                   /note="Nudix hydrolase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00794"
FT   MOTIF           127..148
FT                   /note="Nudix box"
FT   BINDING         142
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         146
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   300 AA;  32712 MW;  99F88F8BF2E8EB8F CRC64;
     MEKVRRILVH LSKENAAPQC ARFLQSITGH FVGSAEDQAT VSCSLENNRF ILGDRLCDGG
     VPLKRASFCP IKYLSDSEAV SLPSETLSRG VDVGVAVLLQ SANQKLLLTR RASSLRSFPN
     VWVPPGGHVE LDEKLLDAGL RELLEETGLN LSPDEICSRL LGLWESVYPP MLTIGLPKRH
     HIVTYILLKS SQTHLQIQAS LRPDPAEVSA CVWVDADLVK AVVSAVDGEK ECVQIPADLP
     ESIGVTKVSP DGEMSESSLP VSVLCNRAPD YGEDIERVST GTKFALELWL KTLEHHADMG