NUD17_HUMAN
ID NUD17_HUMAN Reviewed; 328 AA.
AC P0C025;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Nucleoside diphosphate-linked moiety X motif 17;
DE Short=Nudix motif 17;
DE EC=3.6.1.-;
GN Name=NUDT17;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- FUNCTION: Probably mediates the hydrolysis of some nucleoside
CC diphosphate derivatives. {ECO:0000250}.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC -!- SIMILARITY: Belongs to the Nudix hydrolase family. {ECO:0000305}.
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DR EMBL; AL160282; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS72865.1; -.
DR RefSeq; NP_001012776.1; NM_001012758.2.
DR PDB; 5LF8; X-ray; 2.56 A; A=1-328.
DR PDBsum; 5LF8; -.
DR AlphaFoldDB; P0C025; -.
DR SMR; P0C025; -.
DR STRING; 9606.ENSP00000334437; -.
DR iPTMnet; P0C025; -.
DR PhosphoSitePlus; P0C025; -.
DR BioMuta; NUDT17; -.
DR DMDM; 254763318; -.
DR jPOST; P0C025; -.
DR PaxDb; P0C025; -.
DR PRIDE; P0C025; -.
DR ProteomicsDB; 52289; -.
DR Antibodypedia; 33964; 43 antibodies from 15 providers.
DR DNASU; 200035; -.
DR Ensembl; ENST00000334513.6; ENSP00000334437.5; ENSG00000186364.12.
DR GeneID; 200035; -.
DR KEGG; hsa:200035; -.
DR MANE-Select; ENST00000334513.6; ENSP00000334437.5; NM_001012758.3; NP_001012776.1.
DR UCSC; uc001eoe.4; human.
DR CTD; 200035; -.
DR DisGeNET; 200035; -.
DR GeneCards; NUDT17; -.
DR HGNC; HGNC:26618; NUDT17.
DR HPA; ENSG00000186364; Low tissue specificity.
DR neXtProt; NX_P0C025; -.
DR OpenTargets; ENSG00000186364; -.
DR PharmGKB; PA134890899; -.
DR VEuPathDB; HostDB:ENSG00000186364; -.
DR eggNOG; ENOG502QWT5; Eukaryota.
DR GeneTree; ENSGT00390000013847; -.
DR HOGENOM; CLU_061877_1_0_1; -.
DR InParanoid; P0C025; -.
DR OMA; VSALMWL; -.
DR OrthoDB; 1602447at2759; -.
DR PhylomeDB; P0C025; -.
DR TreeFam; TF313611; -.
DR PathwayCommons; P0C025; -.
DR SignaLink; P0C025; -.
DR BioGRID-ORCS; 200035; 45 hits in 1077 CRISPR screens.
DR ChiTaRS; NUDT17; human.
DR GenomeRNAi; 200035; -.
DR Pharos; P0C025; Tdark.
DR PRO; PR:P0C025; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; P0C025; protein.
DR Bgee; ENSG00000186364; Expressed in oviduct epithelium and 115 other tissues.
DR Genevisible; P0C025; HS.
DR GO; GO:0005777; C:peroxisome; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035529; F:NADH pyrophosphatase activity; IBA:GO_Central.
DR GO; GO:0019677; P:NAD catabolic process; IBA:GO_Central.
DR GO; GO:0006734; P:NADH metabolic process; IBA:GO_Central.
DR GO; GO:0006742; P:NADP catabolic process; IBA:GO_Central.
DR CDD; cd04694; Nudix_Hydrolase_35; 1.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR000086; NUDIX_hydrolase_dom.
DR InterPro; IPR033716; Nudt17_dom.
DR Pfam; PF00293; NUDIX; 1.
DR SUPFAM; SSF55811; SSF55811; 1.
DR PROSITE; PS51462; NUDIX; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Hydrolase; Magnesium; Manganese; Metal-binding;
KW Reference proteome.
FT CHAIN 1..328
FT /note="Nucleoside diphosphate-linked moiety X motif 17"
FT /id="PRO_0000019953"
FT DOMAIN 90..236
FT /note="Nudix hydrolase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00794"
FT REGION 299..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 127..148
FT /note="Nudix box"
FT BINDING 142
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250"
FT BINDING 146
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250"
FT STRAND 6..8
FT /evidence="ECO:0007829|PDB:5LF8"
FT STRAND 10..13
FT /evidence="ECO:0007829|PDB:5LF8"
FT STRAND 19..21
FT /evidence="ECO:0007829|PDB:5LF8"
FT HELIX 23..27
FT /evidence="ECO:0007829|PDB:5LF8"
FT STRAND 34..42
FT /evidence="ECO:0007829|PDB:5LF8"
FT STRAND 47..52
FT /evidence="ECO:0007829|PDB:5LF8"
FT STRAND 59..64
FT /evidence="ECO:0007829|PDB:5LF8"
FT HELIX 70..74
FT /evidence="ECO:0007829|PDB:5LF8"
FT STRAND 92..100
FT /evidence="ECO:0007829|PDB:5LF8"
FT STRAND 106..111
FT /evidence="ECO:0007829|PDB:5LF8"
FT STRAND 116..118
FT /evidence="ECO:0007829|PDB:5LF8"
FT STRAND 121..123
FT /evidence="ECO:0007829|PDB:5LF8"
FT STRAND 125..128
FT /evidence="ECO:0007829|PDB:5LF8"
FT HELIX 135..147
FT /evidence="ECO:0007829|PDB:5LF8"
FT STRAND 155..171
FT /evidence="ECO:0007829|PDB:5LF8"
FT HELIX 172..174
FT /evidence="ECO:0007829|PDB:5LF8"
FT STRAND 178..192
FT /evidence="ECO:0007829|PDB:5LF8"
FT HELIX 194..199
FT /evidence="ECO:0007829|PDB:5LF8"
FT TURN 205..207
FT /evidence="ECO:0007829|PDB:5LF8"
FT STRAND 208..214
FT /evidence="ECO:0007829|PDB:5LF8"
FT HELIX 216..223
FT /evidence="ECO:0007829|PDB:5LF8"
FT HELIX 261..264
FT /evidence="ECO:0007829|PDB:5LF8"
FT STRAND 276..278
FT /evidence="ECO:0007829|PDB:5LF8"
FT HELIX 280..292
FT /evidence="ECO:0007829|PDB:5LF8"
SQ SEQUENCE 328 AA; 35923 MW; FD6FEF1EFB6E842D CRC64;
MAEVRVQLLL SRRPESVSFA RSVCGLLGAG PGLGTWPIHC SLKRGRLVLS SRPFPGASAR
LPLQRPPFCP FAALEERPRV PGAELPTDRG VDLGVAVILQ SSDKTVLLTR RARTLSVSPN
LWVPPGGHVE LEEELLDGGL RELWEESGLH LPQGQFSWVP LGLWESAYPP RLSWGLPKYH
HIVLYLLVIS QESQQQLQAR IQPNPNEVSA LMWLTPDVAA AVAAAEDGTE TPGLLPQDLP
PSVLAVELEE DGRARPLVLH MSTLLRMIPT MAEDKERVST GTKFALKLWL QHLGRTPPPC
KSAAYLDPGP AKEEWNMDPL PPNQGSGK
