ID   NUD17_XENLA             Reviewed;         296 AA.
AC   Q5PQ04;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Nucleoside diphosphate-linked moiety X motif 17;
DE            Short=Nudix motif 17;
DE            EC=3.6.1.-;
GN   Name=nudt17;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably mediates the hydrolysis of some nucleoside
CC       diphosphate derivatives. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the Nudix hydrolase family. {ECO:0000305}.
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DR   EMBL; BC087418; AAH87418.1; -; mRNA.
DR   RefSeq; NP_001088761.1; NM_001095292.1.
DR   AlphaFoldDB; Q5PQ04; -.
DR   SMR; Q5PQ04; -.
DR   MaxQB; Q5PQ04; -.
DR   DNASU; 496025; -.
DR   GeneID; 496025; -.
DR   KEGG; xla:496025; -.
DR   CTD; 496025; -.
DR   Xenbase; XB-GENE-979162; nudt17.L.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 496025; Expressed in internal ear and 19 other tissues.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd04694; Nudix_Hydrolase_35; 1.
DR   InterPro; IPR020476; Nudix_hydrolase.
DR   InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR   InterPro; IPR000086; NUDIX_hydrolase_dom.
DR   InterPro; IPR033716; Nudt17_dom.
DR   Pfam; PF00293; NUDIX; 1.
DR   PRINTS; PR00502; NUDIXFAMILY.
DR   SUPFAM; SSF55811; SSF55811; 1.
DR   PROSITE; PS51462; NUDIX; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Magnesium; Manganese; Metal-binding; Reference proteome.
FT   CHAIN           1..296
FT                   /note="Nucleoside diphosphate-linked moiety X motif 17"
FT                   /id="PRO_0000380518"
FT   DOMAIN          90..236
FT                   /note="Nudix hydrolase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00794"
FT   MOTIF           129..150
FT                   /note="Nudix box"
FT   BINDING         144
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         148
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   296 AA;  32542 MW;  DB2C7C61300E8553 CRC64;
     MESAKRVLVY LTKENSLLQC AKFAQGITGH YSANNGDKAF IHCGLEKNQF VISDCQFLGS
     ARVQLQRPSF CPIKNLSPRQ SASLPQEIQG RGVDVGVAVL VQSINKKVLL TRRSKSLNIF
     PNVWVPPGGH VELGEQLLEA GLRELQEETG LRLQEVSWSM LGLWESAFPP LLSRGLPSRH
     HIVTYLLVQT NETHQQMQER LCPDEREVSA CVWLDTEIAK HIVAAEDSGS PCGPLPASIS
     VLELIHGSLS QSDRSMATFL NSAPKEGEDI ERISTGTKYA LSLWLDGMPT NSSPCA