ID   NUD17_XENTR             Reviewed;         301 AA.
AC   Q5M8V2;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 2.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Nucleoside diphosphate-linked moiety X motif 17;
DE            Short=Nudix motif 17;
DE            EC=3.6.1.-;
GN   Name=nudt17;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably mediates the hydrolysis of some nucleoside
CC       diphosphate derivatives. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the Nudix hydrolase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH87815.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC087815; AAH87815.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q5M8V2; -.
DR   SMR; Q5M8V2; -.
DR   STRING; 8364.ENSXETP00000040431; -.
DR   PaxDb; Q5M8V2; -.
DR   PRIDE; Q5M8V2; -.
DR   eggNOG; ENOG502QWT5; Eukaryota.
DR   HOGENOM; CLU_061877_1_0_1; -.
DR   InParanoid; Q5M8V2; -.
DR   PhylomeDB; Q5M8V2; -.
DR   TreeFam; TF313611; -.
DR   Proteomes; UP000008143; Genome assembly.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005777; C:peroxisome; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0035529; F:NADH pyrophosphatase activity; IBA:GO_Central.
DR   GO; GO:0019677; P:NAD catabolic process; IBA:GO_Central.
DR   GO; GO:0006734; P:NADH metabolic process; IBA:GO_Central.
DR   GO; GO:0006742; P:NADP catabolic process; IBA:GO_Central.
DR   CDD; cd04694; Nudix_Hydrolase_35; 1.
DR   InterPro; IPR020476; Nudix_hydrolase.
DR   InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR   InterPro; IPR000086; NUDIX_hydrolase_dom.
DR   InterPro; IPR033716; Nudt17_dom.
DR   Pfam; PF00293; NUDIX; 1.
DR   PRINTS; PR00502; NUDIXFAMILY.
DR   SUPFAM; SSF55811; SSF55811; 1.
DR   PROSITE; PS51462; NUDIX; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Magnesium; Manganese; Metal-binding; Reference proteome.
FT   CHAIN           1..301
FT                   /note="Nucleoside diphosphate-linked moiety X motif 17"
FT                   /id="PRO_0000380519"
FT   DOMAIN          90..236
FT                   /note="Nudix hydrolase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00794"
FT   MOTIF           129..150
FT                   /note="Nudix box"
FT   BINDING         144
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         148
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   301 AA;  33004 MW;  12F012B45FC1A7D5 CRC64;
     MESAKRVLVC LTKENSLLQC AKFVQGITGQ YSANNGDKAL IHCGLDRNQF VISDRQFPSS
     APVQLQRPSF CPIKNLSPTQ AAALPGEIRN RGVDVGVAVL VQSVNKKVLL TRRSKSLNIF
     PNVWVPPGGH VEPGEQLLEA GLRELREETG LRLQGVPWCM LGLWESAFPP LLSQGLPSRH
     HIVTYLLVQS NQTHQQLQER LCPDEREVSA CVWLDTEIAK CIVAAEDDAK DSGKPQGPAP
     ATIRVSELIN GSLSQSDRSM ATFLSTAPKE GEAVERISTG TKYALSLWLE TLPKAPSREH
     E