ID   NUD18_DANRE             Reviewed;         325 AA.
AC   Q568Q0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=8-oxo-dGDP phosphatase NUDT18;
DE            EC=3.6.1.58;
DE   AltName: Full=2-hydroxy-dADP phosphatase;
DE   AltName: Full=7,8-dihydro-8-oxoguanine phosphatase;
DE   AltName: Full=Nucleoside diphosphate-linked moiety X motif 18;
DE            Short=Nudix motif 18;
GN   Name=nudt18; ORFNames=zgc:110174;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the hydrolysis of oxidized nucleoside diphosphate
CC       derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing
CC       deoxyribo- and ribonucleoside diphosphates to the monophosphates.
CC       Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies.
CC       Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Probably removes oxidized
CC       guanine nucleotides from both the DNA and RNA precursor pools (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=8-oxo-dGDP + H2O = 8-oxo-dGMP + H(+) + phosphate;
CC         Xref=Rhea:RHEA:32063, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:63224, ChEBI:CHEBI:63715; EC=3.6.1.58;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the Nudix hydrolase family. {ECO:0000305}.
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DR   EMBL; BC092771; AAH92771.1; -; mRNA.
DR   RefSeq; NP_001017843.1; NM_001017843.1.
DR   AlphaFoldDB; Q568Q0; -.
DR   SMR; Q568Q0; -.
DR   STRING; 7955.ENSDARP00000060954; -.
DR   PaxDb; Q568Q0; -.
DR   PRIDE; Q568Q0; -.
DR   DNASU; 550541; -.
DR   GeneID; 550541; -.
DR   KEGG; dre:550541; -.
DR   CTD; 79873; -.
DR   ZFIN; ZDB-GENE-050417-388; nudt18.
DR   eggNOG; KOG0648; Eukaryota.
DR   InParanoid; Q568Q0; -.
DR   PhylomeDB; Q568Q0; -.
DR   Reactome; R-DRE-2393930; Phosphate bond hydrolysis by NUDT proteins.
DR   PRO; PR:Q568Q0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0044717; F:8-hydroxy-dADP phosphatase activity; ISS:UniProtKB.
DR   GO; GO:0044715; F:8-oxo-dGDP phosphatase activity; ISS:UniProtKB.
DR   GO; GO:0044716; F:8-oxo-GDP phosphatase activity; ISS:UniProtKB.
DR   GO; GO:0000287; F:magnesium ion binding; ISS:UniProtKB.
DR   GO; GO:0046057; P:dADP catabolic process; ISS:UniProtKB.
DR   GO; GO:0046067; P:dGDP catabolic process; ISS:UniProtKB.
DR   GO; GO:0046712; P:GDP catabolic process; ISS:UniProtKB.
DR   CDD; cd04671; Nudix_Hydrolase_13; 1.
DR   InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR   InterPro; IPR020084; NUDIX_hydrolase_CS.
DR   InterPro; IPR000086; NUDIX_hydrolase_dom.
DR   InterPro; IPR042970; NUDT18_NUDIX.
DR   Pfam; PF00293; NUDIX; 1.
DR   SUPFAM; SSF55811; SSF55811; 1.
DR   PROSITE; PS51462; NUDIX; 1.
DR   PROSITE; PS00893; NUDIX_BOX; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Magnesium; Manganese; Metal-binding; Nucleotide metabolism;
KW   Reference proteome.
FT   CHAIN           1..325
FT                   /note="8-oxo-dGDP phosphatase NUDT18"
FT                   /id="PRO_0000324570"
FT   DOMAIN          38..163
FT                   /note="Nudix hydrolase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00794"
FT   MOTIF           73..94
FT                   /note="Nudix box"
FT   BINDING         88
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         92
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   325 AA;  36900 MW;  09CDBA44C5005903 CRC64;
     MDSQSSILEE NLEKILRGEG LEFDSVAEQV DPVTLRKNVC YIVGAVIFNS KEEVLMVQEA
     KRECYGRWYL PAGRMEECES ILEALQREVR EEAGIDCQPI TLLLVQEQGP RWVRFIFLAE
     ETGGSLKTTA EADDESLQAH WWDRKSPLPL RAHDILSLID AGLKYRRNPW FPVTQPVDFP
     CHVVCQRLFL TFISSRADAD DRLWLLMSNN NTSHHPRLPI VVSFRTYISK AVSKLIEDCM
     PSSYISVHIR GILGVQHNGR IPGKTDGICF NTLVLLENTE EGAEIGSPPS LETDCYRWQE
     VTNQGLKAKI IERIKDGSVL PFQSL