NUDL_ECOLI
ID NUDL_ECOLI Reviewed; 192 AA.
AC P43337;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Uncharacterized Nudix hydrolase NudL {ECO:0000255|HAMAP-Rule:MF_01592};
DE EC=3.6.1.- {ECO:0000255|HAMAP-Rule:MF_01592};
GN Name=nudL {ECO:0000255|HAMAP-Rule:MF_01592}; Synonyms=yeaB;
GN OrderedLocusNames=b1813, JW1802;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097040; DOI=10.1093/dnares/3.6.379;
RA Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K.,
RA Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T.,
RA Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., Nakamura Y.,
RA Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y.,
RA Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y.,
RA Horiuchi T.;
RT "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 40.1-50.0 min region on the linkage map.";
RL DNA Res. 3:379-392(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-41.
RX PubMed=6330050; DOI=10.1128/jb.159.1.57-62.1984;
RA Goncharoff P., Nichols B.P.;
RT "Nucleotide sequence of Escherichia coli pabB indicates a common
RT evolutionary origin of p-aminobenzoate synthetase and anthranilate
RT synthetase.";
RL J. Bacteriol. 159:57-62(1984).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-192.
RC STRAIN=K12;
RX PubMed=2504697; DOI=10.1128/jb.171.9.5095-5102.1989;
RA Su H., Lang B.F., Newman E.B.;
RT "L-serine degradation in Escherichia coli K-12: cloning and sequencing of
RT the sdaA gene.";
RL J. Bacteriol. 171:5095-5102(1989).
RN [6]
RP IDENTIFICATION.
RX PubMed=7567469; DOI=10.1093/nar/23.17.3554;
RA Borodovsky M., McIninch J., Koonin E.V., Rudd K.E., Medigue C., Danchin A.;
RT "Detection of new genes in a bacterial genome using Markov models for three
RT gene classes.";
RL Nucleic Acids Res. 23:3554-3562(1995).
CC -!- FUNCTION: Probably mediates the hydrolysis of some nucleoside
CC diphosphate derivatives. {ECO:0000255|HAMAP-Rule:MF_01592}.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01592};
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01592};
CC -!- SIMILARITY: Belongs to the Nudix hydrolase family. PCD1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01592}.
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DR EMBL; U00096; AAC74883.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA15620.1; -; Genomic_DNA.
DR EMBL; K02673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M28695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; E64942; E64942.
DR RefSeq; NP_416327.1; NC_000913.3.
DR RefSeq; WP_000456715.1; NZ_SSZK01000001.1.
DR AlphaFoldDB; P43337; -.
DR SMR; P43337; -.
DR BioGRID; 4263367; 35.
DR DIP; DIP-11783N; -.
DR IntAct; P43337; 5.
DR STRING; 511145.b1813; -.
DR jPOST; P43337; -.
DR PaxDb; P43337; -.
DR PRIDE; P43337; -.
DR EnsemblBacteria; AAC74883; AAC74883; b1813.
DR EnsemblBacteria; BAA15620; BAA15620; BAA15620.
DR GeneID; 946330; -.
DR KEGG; ecj:JW1802; -.
DR KEGG; eco:b1813; -.
DR PATRIC; fig|1411691.4.peg.439; -.
DR EchoBASE; EB2556; -.
DR eggNOG; COG0494; Bacteria.
DR HOGENOM; CLU_040940_5_2_6; -.
DR InParanoid; P43337; -.
DR OMA; YYIWGAT; -.
DR PhylomeDB; P43337; -.
DR BioCyc; EcoCyc:EG12693-MON; -.
DR BioCyc; MetaCyc:EG12693-MON; -.
DR PRO; PR:P43337; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0010945; F:CoA pyrophosphatase activity; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IDA:EcoCyc.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009132; P:nucleoside diphosphate metabolic process; IEA:InterPro.
DR CDD; cd03426; CoAse; 1.
DR HAMAP; MF_01592; Nudix_NudL; 1.
DR InterPro; IPR045121; CoAse.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR000086; NUDIX_hydrolase_dom.
DR InterPro; IPR000059; NUDIX_hydrolase_NudL_CS.
DR InterPro; IPR023735; Nudix_NudL.
DR PANTHER; PTHR12992; PTHR12992; 1.
DR Pfam; PF00293; NUDIX; 1.
DR SUPFAM; SSF55811; SSF55811; 1.
DR PROSITE; PS51462; NUDIX; 1.
DR PROSITE; PS01293; NUDIX_COA; 1.
PE 3: Inferred from homology;
KW Hydrolase; Magnesium; Manganese; Metal-binding; Reference proteome.
FT CHAIN 1..192
FT /note="Uncharacterized Nudix hydrolase NudL"
FT /id="PRO_0000057145"
FT DOMAIN 29..160
FT /note="Nudix hydrolase"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01592"
FT MOTIF 67..89
FT /note="Nudix box"
FT BINDING 83
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01592"
FT BINDING 87
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01592"
SQ SEQUENCE 192 AA; 21436 MW; A4CAEC50B1767ECF CRC64;
MEYRSLTLDD FLSRFQLLRP QINRETLNHR QAAVLIPIVR RPQPGLLLTQ RSIHLRKHAG
QVAFPGGAVD DTDASAIAAA LREAEEEVAI PPSAVEVIGV LPPVDSVTGY QVTPVVGIIP
PDLPYRASED EVSAVFEMPL AQALHLGRYH PLDIYRRGDS HRVWLSWYEQ YFVWGMTAGI
IRELALQIGV KP
