NUDL_SALTY
ID NUDL_SALTY Reviewed; 192 AA.
AC P0A2K9; P43339;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Uncharacterized Nudix hydrolase NudL {ECO:0000255|HAMAP-Rule:MF_01592};
DE EC=3.6.1.- {ECO:0000255|HAMAP-Rule:MF_01592};
GN Name=nudL {ECO:0000255|HAMAP-Rule:MF_01592}; OrderedLocusNames=STM1825;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-80.
RX PubMed=3057324; DOI=10.1093/oxfordjournals.molbev.a040512;
RA Goncharoff P., Nichols B.P.;
RT "Evolution of aminobenzoate synthases: nucleotide sequences of Salmonella
RT typhimurium and Klebsiella aerogenes pabB.";
RL Mol. Biol. Evol. 5:531-548(1988).
RN [3]
RP IDENTIFICATION.
RX PubMed=7567469; DOI=10.1093/nar/23.17.3554;
RA Borodovsky M., McIninch J., Koonin E.V., Rudd K.E., Medigue C., Danchin A.;
RT "Detection of new genes in a bacterial genome using Markov models for three
RT gene classes.";
RL Nucleic Acids Res. 23:3554-3562(1995).
CC -!- FUNCTION: Probably mediates the hydrolysis of some nucleoside
CC diphosphate derivatives. {ECO:0000255|HAMAP-Rule:MF_01592}.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01592};
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01592};
CC -!- SIMILARITY: Belongs to the Nudix hydrolase family. PCD1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01592}.
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DR EMBL; AE006468; AAL20740.1; -; Genomic_DNA.
DR EMBL; M22079; AAA88619.1; -; Genomic_DNA.
DR RefSeq; NP_460781.1; NC_003197.2.
DR RefSeq; WP_000381544.1; NC_003197.2.
DR AlphaFoldDB; P0A2K9; -.
DR SMR; P0A2K9; -.
DR STRING; 99287.STM1825; -.
DR PaxDb; P0A2K9; -.
DR EnsemblBacteria; AAL20740; AAL20740; STM1825.
DR GeneID; 1253344; -.
DR KEGG; stm:STM1825; -.
DR PATRIC; fig|99287.12.peg.1925; -.
DR HOGENOM; CLU_040940_5_2_6; -.
DR OMA; YYIWGAT; -.
DR PhylomeDB; P0A2K9; -.
DR BioCyc; SENT99287:STM1825-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0010945; F:CoA pyrophosphatase activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009132; P:nucleoside diphosphate metabolic process; IEA:InterPro.
DR CDD; cd03426; CoAse; 1.
DR HAMAP; MF_01592; Nudix_NudL; 1.
DR InterPro; IPR045121; CoAse.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR000086; NUDIX_hydrolase_dom.
DR InterPro; IPR000059; NUDIX_hydrolase_NudL_CS.
DR InterPro; IPR023735; Nudix_NudL.
DR PANTHER; PTHR12992; PTHR12992; 1.
DR Pfam; PF00293; NUDIX; 1.
DR SUPFAM; SSF55811; SSF55811; 1.
DR PROSITE; PS51462; NUDIX; 1.
DR PROSITE; PS01293; NUDIX_COA; 1.
PE 3: Inferred from homology;
KW Hydrolase; Magnesium; Manganese; Metal-binding; Reference proteome.
FT CHAIN 1..192
FT /note="Uncharacterized Nudix hydrolase NudL"
FT /id="PRO_0000057148"
FT DOMAIN 29..160
FT /note="Nudix hydrolase"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01592"
FT MOTIF 67..89
FT /note="Nudix box"
FT BINDING 83
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01592"
FT BINDING 87
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01592"
SQ SEQUENCE 192 AA; 21431 MW; 45966C6DC1518B49 CRC64;
MDTSRLTLDH FLSRFQLLRP QMTHETLNQR QAAVLIPVVR RPQPGLLLTQ RAIHLRKHAG
QVAFPGGAVD STDASLIAAA LREAQEEVAI PPQAVEVIGV LPPVDSVTGF QVTPVVGIIP
PNLPWRASED EVSAVFEMPL AQALQLGRYH PLDVYRRGNS HRVWLSWYEH YFVWGMTANI
LRELALQIGV KP
