NUDT5_ARATH
ID NUDT5_ARATH Reviewed; 302 AA.
AC Q9SJC6; F4IV87; Q6NNG2;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 25-JAN-2012, sequence version 3.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Nudix hydrolase 5;
DE Short=AtNUDT5;
DE EC=3.6.1.-;
GN Name=NUDT5; Synonyms=NUDX5; OrderedLocusNames=At2g04430; ORFNames=T1O3.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=15878881; DOI=10.1074/jbc.m503536200;
RA Ogawa T., Ueda Y., Yoshimura K., Shigeoka S.;
RT "Comprehensive analysis of cytosolic nudix hydrolases in Arabidopsis
RT thaliana.";
RL J. Biol. Chem. 280:25277-25283(2005).
CC -!- FUNCTION: Probably mediates the hydrolysis of some nucleoside
CC diphosphate derivatives. {ECO:0000250}.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC -!- TISSUE SPECIFICITY: Expressed in roots, stems and leaves.
CC {ECO:0000269|PubMed:15878881}.
CC -!- SIMILARITY: Belongs to the Nudix hydrolase family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD25835.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC006951; AAD25835.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002685; AEC05835.1; -; Genomic_DNA.
DR EMBL; BT010760; AAR23730.1; -; mRNA.
DR EMBL; BT011326; AAR92362.1; -; mRNA.
DR PIR; E84457; E84457.
DR RefSeq; NP_001324657.1; NM_001335236.1.
DR RefSeq; NP_178524.2; NM_126476.3.
DR AlphaFoldDB; Q9SJC6; -.
DR SMR; Q9SJC6; -.
DR STRING; 3702.AT2G04430.1; -.
DR iPTMnet; Q9SJC6; -.
DR PaxDb; Q9SJC6; -.
DR PRIDE; Q9SJC6; -.
DR ProteomicsDB; 250526; -.
DR EnsemblPlants; AT2G04430.1; AT2G04430.1; AT2G04430.
DR GeneID; 814983; -.
DR Gramene; AT2G04430.1; AT2G04430.1; AT2G04430.
DR KEGG; ath:AT2G04430; -.
DR Araport; AT2G04430; -.
DR TAIR; locus:2058364; AT2G04430.
DR eggNOG; KOG0648; Eukaryota.
DR HOGENOM; CLU_054299_1_0_1; -.
DR InParanoid; Q9SJC6; -.
DR OrthoDB; 835461at2759; -.
DR BioCyc; ARA:AT2G04430-MON; -.
DR PRO; PR:Q9SJC6; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SJC6; baseline and differential.
DR Genevisible; Q9SJC6; AT.
DR GO; GO:0005829; C:cytosol; ISM:TAIR.
DR GO; GO:0047631; F:ADP-ribose diphosphatase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051287; F:NAD binding; IBA:GO_Central.
DR GO; GO:0035529; F:NADH pyrophosphatase activity; IBA:GO_Central.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR003293; Nudix_hydrolase6-like.
DR InterPro; IPR020084; NUDIX_hydrolase_CS.
DR InterPro; IPR000086; NUDIX_hydrolase_dom.
DR InterPro; IPR040618; Pre-Nudix.
DR PANTHER; PTHR13994; PTHR13994; 1.
DR Pfam; PF00293; NUDIX; 1.
DR Pfam; PF18290; Nudix_hydro; 1.
DR PRINTS; PR01356; GFGPROTEIN.
DR SUPFAM; SSF55811; SSF55811; 1.
DR PROSITE; PS51462; NUDIX; 1.
DR PROSITE; PS00893; NUDIX_BOX; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Magnesium; Manganese; Metal-binding; Reference proteome.
FT CHAIN 1..302
FT /note="Nudix hydrolase 5"
FT /id="PRO_0000057125"
FT DOMAIN 122..254
FT /note="Nudix hydrolase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00794"
FT MOTIF 159..180
FT /note="Nudix box"
FT BINDING 174
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250"
FT BINDING 178
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250"
SQ SEQUENCE 302 AA; 34294 MW; EF76C8D09A6565CC CRC64;
MGLTKNFAFL VFCCQRYCSM DGEAFEISLL DGEEDRFGGT VVNLMEVESM TIGDFDSKLD
VSLKAWKDQG KKGIWIKLPS ELSSLVDTAI KKGFTYHHAE NEYVMLTFWL PEPPSTLPCN
ASHRIGIGAF VLNKNGEMLV VQENSGYFKD KNVWKVPTGT IKEGESIWAG AVREVKEETD
IDAEFVEVLS FMESHQAVWQ RKTDIFFVCE LEARTFEIQK QDSEIHAAKW MPVEEYVNQP
YHNKEGNEMF KLIANICLKR SREKYTGFVL TTNSAKKSLY CSVDHANLLK ETADQASTSL
SD
