NUDT6_MOUSE
ID NUDT6_MOUSE Reviewed; 313 AA.
AC Q8CH40; Q8R2T3;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=Nucleoside diphosphate-linked moiety X motif 6;
DE Short=Nudix motif 6;
DE EC=3.6.1.-;
DE AltName: Full=Antisense basic fibroblast growth factor B;
GN Name=Nudt6; Synonyms=Asfgf2b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RA Liu Y., Wang Z., Lagowski J.P., Kulesz-Martin M.F.;
RT "Identification of a bi-directional locus of SPAF and AS-FGF2 and its
RT activation in early spermatogenesis and malignant progression.";
RL Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, and Heart;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May contribute to the regulation of cell proliferation.
CC {ECO:0000250}.
CC -!- SUBUNIT: Monomer and homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Mitochondrion {ECO:0000250}.
CC -!- MISCELLANEOUS: This protein is coded from a FGF2 (BFGF) gene antisense
CC transcript.
CC -!- SIMILARITY: Belongs to the Nudix hydrolase family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF453428; AAN76848.1; -; mRNA.
DR EMBL; BC027267; AAH27267.1; -; mRNA.
DR CCDS; CCDS71237.1; -.
DR RefSeq; NP_705789.1; NM_153561.3.
DR AlphaFoldDB; Q8CH40; -.
DR SMR; Q8CH40; -.
DR STRING; 10090.ENSMUSP00000056219; -.
DR iPTMnet; Q8CH40; -.
DR PhosphoSitePlus; Q8CH40; -.
DR MaxQB; Q8CH40; -.
DR PaxDb; Q8CH40; -.
DR PRIDE; Q8CH40; -.
DR ProteomicsDB; 287853; -.
DR DNASU; 229228; -.
DR GeneID; 229228; -.
DR KEGG; mmu:229228; -.
DR CTD; 11162; -.
DR MGI; MGI:2387618; Nudt6.
DR eggNOG; KOG0648; Eukaryota.
DR InParanoid; Q8CH40; -.
DR PhylomeDB; Q8CH40; -.
DR BioGRID-ORCS; 229228; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q8CH40; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8CH40; protein.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0047631; F:ADP-ribose diphosphatase activity; IBA:GO_Central.
DR GO; GO:0051287; F:NAD binding; IBA:GO_Central.
DR GO; GO:0035529; F:NADH pyrophosphatase activity; IBA:GO_Central.
DR GO; GO:0045786; P:negative regulation of cell cycle; ISO:MGI.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:MGI.
DR InterPro; IPR020476; Nudix_hydrolase.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR003293; Nudix_hydrolase6-like.
DR InterPro; IPR020084; NUDIX_hydrolase_CS.
DR InterPro; IPR000086; NUDIX_hydrolase_dom.
DR InterPro; IPR040618; Pre-Nudix.
DR PANTHER; PTHR13994; PTHR13994; 1.
DR Pfam; PF00293; NUDIX; 1.
DR Pfam; PF18290; Nudix_hydro; 1.
DR PRINTS; PR01356; GFGPROTEIN.
DR PRINTS; PR00502; NUDIXFAMILY.
DR SUPFAM; SSF55811; SSF55811; 1.
DR PROSITE; PS51462; NUDIX; 1.
DR PROSITE; PS00893; NUDIX_BOX; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Hydrolase; Mitochondrion; Nucleus; Reference proteome.
FT CHAIN 1..313
FT /note="Nucleoside diphosphate-linked moiety X motif 6"
FT /id="PRO_0000057108"
FT DOMAIN 138..270
FT /note="Nudix hydrolase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00794"
FT CONFLICT 85
FT /note="D -> E (in Ref. 2; AAH27267)"
FT /evidence="ECO:0000305"
FT CONFLICT 182
FT /note="Missing (in Ref. 2; AAH27267)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 313 AA; 35197 MW; C6BAC07C54D6B1E7 CRC64;
MWWVRRTRYW FSTLLYAGGA RLRPGRRTAS GGLETPGSCG AELQGELDRF GGVSVHLSRH
HTLHGLDAAA FRRLLQAAIQ QWRSDGRIAA WLHIPILQSH FIAPAASLGF CFHHAKPHSS
TLTLWLGEGP SRLPGYATHQ VGVAGAVFDV STRKVLVVQD RNKLKNMWKF PGGLSEPGED
IADTAVREVF EETGVKSEFR SLLSIRQQHR SPGAFGMSDM YLVCRLQPRS FTINFCQQEC
LKCEWIDLEN LARTKHTTPI TSRVARLLLY GLREGFDKID LSMEELPAVY TGLFYKLYHR
ELPESYKAAT GAD
