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NUF2B_XENLA
ID   NUF2B_XENLA             Reviewed;         462 AA.
AC   Q6GQ71; Q498I2;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 2.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Kinetochore protein Nuf2-B;
DE   AltName: Full=Cell division cycle-associated protein 1-B;
GN   Name=nuf2-b; Synonyms=cdca1-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. Required for kinetochore integrity and the
CC       organization of stable microtubule binding sites in the outer plate of
CC       the kinetochore. The NDC80 complex synergistically enhances the
CC       affinity of the SKA1 complex for microtubules and may allow the NDC80
CC       complex to track depolymerizing microtubules.
CC       {ECO:0000250|UniProtKB:Q9BZD4}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which is composed of ndc80,
CC       cdca1, spbc24 and spbc25. The NDC80 complex interacts with mis12 and
CC       zwint (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC       kinetochore {ECO:0000250}. Note=Localizes to kinetochores from late
CC       prophase to anaphase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NUF2 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH72877.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC       Sequence=AAI00208.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC072877; AAH72877.1; ALT_SEQ; mRNA.
DR   EMBL; BC100207; AAI00208.1; ALT_INIT; mRNA.
DR   RefSeq; XP_018116557.1; XM_018261068.1.
DR   AlphaFoldDB; Q6GQ71; -.
DR   SMR; Q6GQ71; -.
DR   GeneID; 443588; -.
DR   KEGG; xla:443588; -.
DR   CTD; 443588; -.
DR   Xenbase; XB-GENE-6252105; nuf2.S.
DR   OrthoDB; 752521at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 443588; Expressed in blastula and 11 other tissues.
DR   GO; GO:0031262; C:Ndc80 complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.418.60; -; 1.
DR   InterPro; IPR005549; Kinetochore_Nuf2_N.
DR   InterPro; IPR038275; Nuf2_N_sf.
DR   Pfam; PF03800; Nuf2; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..462
FT                   /note="Kinetochore protein Nuf2-B"
FT                   /id="PRO_0000249819"
FT   REGION          236..259
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          143..462
FT                   /evidence="ECO:0000255"
FT   CONFLICT        390
FT                   /note="R -> H (in Ref. 1; AAH72877)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        423
FT                   /note="I -> V (in Ref. 1; AAH72877)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   462 AA;  54631 MW;  0A4D7726AC21B7F5 CRC64;
     MDKLTFPIFP AADLVNFFRQ NILTGTEAKN FNKNDLYPNP KPEMVQKLYM RILQQVFSYG
     VEQFYMVPMD LDIQYPHLVE GFAPVANILK LMARLLPMCR VYDFHPSDVL NPKGKRTLHL
     LSGIFNFLQF RTTQREVYME YCSGYKSALE NVRQLQKTNH EAEIKIEKLT TVPPEQQAEF
     KALSSEIHDL QQIISQEYRA KDVMFQEKIA QRKAEFAEKN KRLNEQKLTI ATMKEEQERM
     KSQIVESPEQ RKSKTERMKE TVHRLKQARQ ETSDKCDHYR DRVALAFMWQ SDVQGYLKKL
     QNIDANLEIH RKIHEEIRHI EEQLMNLNLE LKSLSNEDAQ LKRIILVKKE KLAKVDIKNK
     KKQEDFNQQK QEILEVCSHI QEKRQVIHGR VAQVLQEIQQ TISKKEQLLE TTEAGKNKCQ
     EVITDFRAAL EKYHDSLQKA SERSADRRRE KIAELNRRLS RQ
 
 
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