ID   NUF2_ASPFU              Reviewed;         463 AA.
AC   Q4WVA0;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 3.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Probable kinetochore protein nuf2;
GN   Name=nuf2; ORFNames=AFUA_5G11350;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of at least
CC       ndc80, nuf2 and spc24. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC       kinetochore {ECO:0000250}. Note=Associated with kinetochores.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NUF2 family. {ECO:0000305}.
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DR   EMBL; AAHF01000003; EAL91476.2; -; Genomic_DNA.
DR   RefSeq; XP_753514.2; XM_748421.2.
DR   AlphaFoldDB; Q4WVA0; -.
DR   SMR; Q4WVA0; -.
DR   STRING; 746128.CADAFUBP00005764; -.
DR   EnsemblFungi; EAL91476; EAL91476; AFUA_5G11350.
DR   GeneID; 3511093; -.
DR   KEGG; afm:AFUA_5G11350; -.
DR   VEuPathDB; FungiDB:Afu5g11350; -.
DR   eggNOG; KOG4438; Eukaryota.
DR   HOGENOM; CLU_025461_2_1_1; -.
DR   InParanoid; Q4WVA0; -.
DR   OMA; AHIKLYI; -.
DR   OrthoDB; 752521at2759; -.
DR   Proteomes; UP000002530; Chromosome 5.
DR   GO; GO:0031262; C:Ndc80 complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0044877; F:protein-containing complex binding; IBA:GO_Central.
DR   GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0051383; P:kinetochore organization; IBA:GO_Central.
DR   GO; GO:0045132; P:meiotic chromosome segregation; IBA:GO_Central.
DR   GO; GO:0007052; P:mitotic spindle organization; IBA:GO_Central.
DR   Gene3D; 1.10.418.60; -; 1.
DR   InterPro; IPR005549; Kinetochore_Nuf2_N.
DR   InterPro; IPR041112; Nuf2_DHR10-like.
DR   InterPro; IPR038275; Nuf2_N_sf.
DR   Pfam; PF18595; DHR10; 1.
DR   Pfam; PF03800; Nuf2; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..463
FT                   /note="Probable kinetochore protein nuf2"
FT                   /id="PRO_0000246645"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          331..354
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          166..455
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   463 AA;  54724 MW;  326B86AF6289131F CRC64;
     MAYNHRMSQQ FHGTQQHHNR GRKKEDENDA LMRLPDKEIA GCINDIGIPF TAADLIKPNP
     QQIQMVFEWF AELLMNTTKE TVEPAMRAAA EDICGDYPDI VPLETRNLMG FFISLRRLMM
     ECGVNDFTFT DLTKPTHDRL VKIFSYLINF VRFRESQTQV IDEHFNKTEK TKARIDTLFM
     ENQEMEQRLE EMRRSLKANE AQVKEKVRRN DELKARLLEL RRNQERIAET LERVKADKAR
     RQAQLEEKTE RSVRTRQEVE KLRPYAMQSP VSLQSALTEL SENLLREKAQ IDAMEKRARA
     LQTSSDTFTV VGNDVQACIK LLEDISVELQ KEEEEESRAS RNKEAISERG NNVREVEQTE
     KLLQRQLARW NERIEALRKN AQEKAEVAQA RMDELRDVQK KLREERAEKQ RDMERRRIRI
     EQTEKKMADL KENIENEIQS AHEEYLKLES HIKLYITEME KCL