ID   NUF2_ASPOR              Reviewed;         463 AA.
AC   Q2UEA0;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Probable kinetochore protein nuf2;
GN   Name=nuf2; ORFNames=AO090026000704;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of ndc80, nuf2,
CC       spc24 and spc25. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC       kinetochore {ECO:0000250}. Note=Associated with kinetochores.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NUF2 family. {ECO:0000305}.
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DR   EMBL; AP007159; BAE60115.1; -; Genomic_DNA.
DR   RefSeq; XP_001822117.1; XM_001822065.2.
DR   AlphaFoldDB; Q2UEA0; -.
DR   SMR; Q2UEA0; -.
DR   STRING; 510516.Q2UEA0; -.
DR   EnsemblFungi; BAE60115; BAE60115; AO090026000704.
DR   GeneID; 5994145; -.
DR   KEGG; aor:AO090026000704; -.
DR   VEuPathDB; FungiDB:AO090026000704; -.
DR   HOGENOM; CLU_025461_2_1_1; -.
DR   OMA; AHIKLYI; -.
DR   Proteomes; UP000006564; Chromosome 3.
DR   GO; GO:0031262; C:Ndc80 complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.418.60; -; 1.
DR   InterPro; IPR005549; Kinetochore_Nuf2_N.
DR   InterPro; IPR041112; Nuf2_DHR10-like.
DR   InterPro; IPR038275; Nuf2_N_sf.
DR   Pfam; PF18595; DHR10; 1.
DR   Pfam; PF03800; Nuf2; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..463
FT                   /note="Probable kinetochore protein nuf2"
FT                   /id="PRO_0000246646"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          330..357
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          166..455
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   463 AA;  54522 MW;  04D0223B874A7956 CRC64;
     MAYNHRMSQQ FRGSQQHHGR GRKKEDENDA LMRLPDKEIA GCINDIGIPF TAADLIKPNP
     QQIQMVFEWF AELLMNITHE AVEPAMRAAA DDVGGDFPDI VPTDTRNLMG FFVSLRKLMM
     ECGVNDFTFT DLTKPTHDRL VKIFSYLINF VRFRESQTPV IDEHFNKSEK TKARIDTLYA
     ENQEMEQRLE EMRRNLRANE AQVKEKVRRN DELKARLLEL RRNQERVAET LERVKADKTR
     RQTQLEEKTE KVVRTRQEVE KLRPYAMESP VSLQASLTEL SENLLREKAQ IDAMEKRARA
     LQTSSDTFTV VSNDVQACVK LLEDISVELQ KEEDEESRAS RNKEAISERG NSVREVEQTE
     KLLQRQLARW NERIETLRKN AQEKAEAAQA RMEELREVQK QLREERAEKQ RDMERRRIRI
     EQTEKKMVDL KENIESEIQS AHDEYLRLES HIKLYITEME KCI