ID   NUF2_CANAL              Reviewed;         485 AA.
AC   Q5A1Q5; A0A1D8PN70;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 3.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Probable kinetochore protein NUF2;
GN   Name=NUF2; OrderedLocusNames=CAALFM_C501280CA;
GN   ORFNames=CaO19.1941, CaO19.9496;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of NDC80, NUF2,
CC       SPC24 and SPC25. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC       kinetochore {ECO:0000250}. Note=Associated with kinetochores.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NUF2 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AOW29563.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CP017627; AOW29563.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_715704.2; XM_710611.2.
DR   AlphaFoldDB; Q5A1Q5; -.
DR   SMR; Q5A1Q5; -.
DR   BioGRID; 1225707; 1.
DR   STRING; 237561.Q5A1Q5; -.
DR   PRIDE; Q5A1Q5; -.
DR   GeneID; 3642613; -.
DR   KEGG; cal:CAALFM_C501280CA; -.
DR   CGD; CAL0000176285; NUF2.
DR   eggNOG; KOG4438; Eukaryota.
DR   HOGENOM; CLU_025461_2_0_1; -.
DR   InParanoid; Q5A1Q5; -.
DR   OrthoDB; 752521at2759; -.
DR   PRO; PR:Q5A1Q5; -.
DR   Proteomes; UP000000559; Chromosome 5.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0031262; C:Ndc80 complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0044877; F:protein-containing complex binding; IBA:GO_Central.
DR   GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0051383; P:kinetochore organization; IBA:GO_Central.
DR   GO; GO:0045132; P:meiotic chromosome segregation; IBA:GO_Central.
DR   GO; GO:0007052; P:mitotic spindle organization; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   Gene3D; 1.10.418.60; -; 1.
DR   InterPro; IPR005549; Kinetochore_Nuf2_N.
DR   InterPro; IPR041112; Nuf2_DHR10-like.
DR   InterPro; IPR038275; Nuf2_N_sf.
DR   InterPro; IPR010989; SNARE.
DR   Pfam; PF18595; DHR10; 1.
DR   Pfam; PF03800; Nuf2; 1.
DR   SUPFAM; SSF47661; SSF47661; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..485
FT                   /note="Probable kinetochore protein NUF2"
FT                   /id="PRO_0000246647"
FT   REGION          87..112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          177..449
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        87..104
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   485 AA;  56646 MW;  6ABB3AF17766C888 CRC64;
     MSRQSFYADP SSAGRQMKYR KDLFPLLDTR EITACLLECE FNVTQELIVK PTADFVTNLF
     EQFLDTFMGI PLGTIRKKAR KMSRINPLES DQANGKPQQS PEEDFNDNQE NDKTKDTFSA
     LQLLILHRYL AIFFSTCGIN DFVLTDIARP DGYRIRRILS AVINFIRFRE DQSPKFDHLA
     NECEATADKV SEVQAENSAT MQKINAIKEK LEMDSENDES NRKNLQYINS YNRKLETKLR
     ELKVMQERLT KEHDDYKQEK ALLAKKLYDI NFLYNETQEQ VANLTKYAET DLSILVKITE
     DLSNDLSSMQ TNYKNLEKSY QNMGITIDSI QVNEINLKDL LKLAEDITRN VEKRQIEGKI
     LKDNQDNLDE LTRKQMELEG QILIVQNQLN KSNKKYQDLI VQADKKESAV KLKLEETKQE
     FNDILSEKEK HNEEHKRIMD QIVKIQQETT AIQDAFVKES KEVELKLINL MSIIKRYMSD
     LRNNI