ID   NUF2_CANGA              Reviewed;         460 AA.
AC   Q6FNH8;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Probable kinetochore protein NUF2;
GN   Name=NUF2; OrderedLocusNames=CAGL0J11572g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of NDC80, NUF2,
CC       SPC24 and SPC25. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC       kinetochore {ECO:0000250}. Note=Associated with kinetochores.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NUF2 family. {ECO:0000305}.
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DR   EMBL; CR380956; CAG61167.1; -; Genomic_DNA.
DR   RefSeq; XP_448216.1; XM_448216.1.
DR   AlphaFoldDB; Q6FNH8; -.
DR   SMR; Q6FNH8; -.
DR   STRING; 5478.XP_448216.1; -.
DR   PRIDE; Q6FNH8; -.
DR   EnsemblFungi; CAG61167; CAG61167; CAGL0J11572g.
DR   GeneID; 2889456; -.
DR   KEGG; cgr:CAGL0J11572g; -.
DR   CGD; CAL0133736; NUF2.
DR   VEuPathDB; FungiDB:CAGL0J11572g; -.
DR   eggNOG; KOG4438; Eukaryota.
DR   HOGENOM; CLU_025461_2_0_1; -.
DR   InParanoid; Q6FNH8; -.
DR   OMA; QCDTERQ; -.
DR   Proteomes; UP000002428; Chromosome J.
DR   GO; GO:0031262; C:Ndc80 complex; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005876; C:spindle microtubule; IEA:EnsemblFungi.
DR   GO; GO:0005816; C:spindle pole body; IEA:EnsemblFungi.
DR   GO; GO:0008017; F:microtubule binding; IEA:EnsemblFungi.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:EnsemblFungi.
DR   Gene3D; 1.10.418.60; -; 1.
DR   InterPro; IPR005549; Kinetochore_Nuf2_N.
DR   InterPro; IPR038275; Nuf2_N_sf.
DR   Pfam; PF03800; Nuf2; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..460
FT                   /note="Probable kinetochore protein NUF2"
FT                   /id="PRO_0000246648"
FT   COILED          155..304
FT                   /evidence="ECO:0000255"
FT   COILED          349..437
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   460 AA;  54195 MW;  D73EF94E5D0B86A5 CRC64;
     MATPTQDIFP LLDLEELVIC LQSCDFAMAT EEHIARPTSQ YVITLYKQII ENFMGISPEQ
     VLAEQLSSRQ NTEGNDESTS VDMFDGPYRE TLQMLTLNKI CYKFFENVGI NDFNIVDLYK
     PEAYRTRRLL SAVVNYARFR EERMFDCNQF IIQMEEMLDE LKSKFDDFNY LKAQLTAIED
     DDEKTPGELE DLLQKNKVLE TNLKKLTILQ EKLSIDYNNY KMKKQELLRE LEKNSFTLIE
     LESKKERLMN YNDDDQDLQN SLNNSIDRLT EEKKKQIGYV SKLEGNVSNL KVTVDTLEKA
     IEHIYDILRL LSTDLQESHR AELNIEGIKG PLTEKRTRLK NLLESNVIYK YDVLKEQLNV
     AETEYQRINE EHYRETLENK KLIQELEGKY NNIIHNKMQE AEVYIENEIT EKKIKILQSE
     LNDIQIQFNN EIDNIELHYS TLVGHINNYM KKLITALNNH