ID   NUF2_DEBHA              Reviewed;         488 AA.
AC   Q6BPA9;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Probable kinetochore protein NUF2;
GN   Name=NUF2; OrderedLocusNames=DEHA2E15092g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of NDC80, NUF2,
CC       SPC24 and SPC25. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC       kinetochore {ECO:0000250}. Note=Associated with kinetochores.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NUF2 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR382137; CAG88207.2; -; Genomic_DNA.
DR   RefSeq; XP_459961.2; XM_459961.1.
DR   AlphaFoldDB; Q6BPA9; -.
DR   SMR; Q6BPA9; -.
DR   STRING; 4959.XP_459961.2; -.
DR   EnsemblFungi; CAG88207; CAG88207; DEHA2E15092g.
DR   GeneID; 2902630; -.
DR   KEGG; dha:DEHA2E15092g; -.
DR   eggNOG; KOG4438; Eukaryota.
DR   HOGENOM; CLU_025461_2_0_1; -.
DR   InParanoid; Q6BPA9; -.
DR   OMA; AHIKLYI; -.
DR   OrthoDB; 752521at2759; -.
DR   Proteomes; UP000000599; Chromosome E.
DR   GO; GO:0031262; C:Ndc80 complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.418.60; -; 1.
DR   InterPro; IPR005549; Kinetochore_Nuf2_N.
DR   InterPro; IPR041112; Nuf2_DHR10-like.
DR   InterPro; IPR038275; Nuf2_N_sf.
DR   Pfam; PF18595; DHR10; 1.
DR   Pfam; PF03800; Nuf2; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..488
FT                   /note="Probable kinetochore protein NUF2"
FT                   /id="PRO_0000246650"
FT   REGION          96..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          186..479
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   488 AA;  56914 MW;  079EADB766A78569 CRC64;
     MSRPSSIYRP GNSSLTSRRI HHVIPQDSFP LLDFKEISIC LQSCDFIANE ELVSRPTSQY
     IKTLLEQLLD SFMGLSADNI NGMVRNVNKN DLSMTKTQDA QMEEEPENGG SQIEDDDDIT
     SSVRLILLHR GAYEFFSICG VNDFTLMDIM RPEPQRIRRI LSAVVNYARF REENSVECEK
     LVSISEGNLE QLKVVQNENS RLSNKINDLK YKIEANETDE GNKKATLKQI TTYNSKLENE
     LKKLKKNQEI LTLEHSKYKD EKRRLIEKLE DHNYLIMESN KELDKLKSYL LSNPEILTKI
     IEDLKTNLSE YQTNLADLES KNKNMTISIE SFQLVEQELK NLFRILEEVL NDLTKEETSL
     DKLNKYQEFK EQQNLTLNDL NRQIQQVTRQ LNNTEEKIKR LRHQSSERSE ASKQKLISLK
     DGYDTLVKER KVKEQELNKK KDFISELETK MNGERSNFQI ELRNAELAVA KLNSHVKLYL
     TEMNKKVD