ID   NUF2_ENCCU              Reviewed;         439 AA.
AC   Q8SQK7;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Probable kinetochore protein NUF2;
GN   Name=NUF2; OrderedLocusNames=ECU09_1690;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of at least
CC       NDC80 and NUF2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC       kinetochore {ECO:0000250}. Note=Associated with kinetochores.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NUF2 family. {ECO:0000305}.
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DR   EMBL; AL590451; CAD27141.1; -; Genomic_DNA.
DR   RefSeq; XP_955722.1; XM_950629.1.
DR   AlphaFoldDB; Q8SQK7; -.
DR   SMR; Q8SQK7; -.
DR   STRING; 284813.Q8SQK7; -.
DR   GeneID; 860508; -.
DR   KEGG; ecu:ECU09_1690; -.
DR   VEuPathDB; MicrosporidiaDB:ECU09_1690; -.
DR   HOGENOM; CLU_025461_1_1_1; -.
DR   InParanoid; Q8SQK7; -.
DR   OMA; AHIKLYI; -.
DR   OrthoDB; 752521at2759; -.
DR   Proteomes; UP000000819; Chromosome IX.
DR   GO; GO:0031262; C:Ndc80 complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.418.60; -; 1.
DR   InterPro; IPR005549; Kinetochore_Nuf2_N.
DR   InterPro; IPR038275; Nuf2_N_sf.
DR   Pfam; PF03800; Nuf2; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..439
FT                   /note="Probable kinetochore protein NUF2"
FT                   /id="PRO_0000246652"
FT   COILED          136..233
FT                   /evidence="ECO:0000255"
FT   COILED          293..332
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   439 AA;  50906 MW;  F0FD9765214F0EC9 CRC64;
     MQKRNVYAVP DLPVKEIMQY FSEMEINIKA SDILKPTPQS TQRIYEVLLE VYCGVKTSDL
     LPRINSGESI EAFEESLSCI LLQKRMSGFL KRIGIDNFGL RDLVPDSRRL IGILSVVVNF
     SMFRDNKRHV YERVCQMNDE KLLLKNEIDE KVHNAKKELE RCERDARKSI EEAKGVEEEI
     SLLESELKDF YRHQRALVQE TERSKTERNE YSDKLSSLKL MVLNLNQEIT CLKTQIVSDP
     TKLMELLDEM RCLIAKESEI MKGLEVKRVG LKEKIEFMQV LKEDTMKAIT LAISNREADK
     TIDKTNREIS ELEVQMKNLD SGINALKIRL NHVSRQISHI ESKIFNLQDN DKRCSEEISA
     KLEKLKSNYG VVSDERNSIR GKIEENVRLT KSIEYELVKR RNEHANDITA IQSALCRLKD
     DVFNYFAEAK GIIDKTMSD