NUF2_GIBZE
ID NUF2_GIBZE Reviewed; 462 AA.
AC Q4IBX0; A0A098DZ73; A0A0E0SI85; V6R9D0;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2005, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Probable kinetochore protein NUF2;
GN Name=NUF2; ORFNames=FGRRES_05288, FGSG_05288;
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC NDC80 complex, which is required for chromosome segregation and spindle
CC checkpoint activity. {ECO:0000250}.
CC -!- SUBUNIT: Component of the NDC80 complex, which consists of NDC80, NUF2,
CC SPC24 and SPC25. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC kinetochore {ECO:0000250}. Note=Associated with kinetochores.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NUF2 family. {ECO:0000305}.
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DR EMBL; DS231665; ESU11223.1; -; Genomic_DNA.
DR EMBL; HG970334; CEF86148.1; -; Genomic_DNA.
DR RefSeq; XP_011323799.1; XM_011325497.1.
DR AlphaFoldDB; Q4IBX0; -.
DR SMR; Q4IBX0; -.
DR STRING; 5518.FGSG_05288P0; -.
DR EnsemblFungi; ESU11223; ESU11223; FGSG_05288.
DR GeneID; 23552476; -.
DR KEGG; fgr:FGSG_05288; -.
DR VEuPathDB; FungiDB:FGRAMPH1_01G17537; -.
DR eggNOG; KOG4438; Eukaryota.
DR HOGENOM; CLU_025461_2_1_1; -.
DR InParanoid; Q4IBX0; -.
DR Proteomes; UP000070720; Chromosome 3.
DR GO; GO:0031262; C:Ndc80 complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 1.10.418.60; -; 1.
DR InterPro; IPR005549; Kinetochore_Nuf2_N.
DR InterPro; IPR041112; Nuf2_DHR10-like.
DR InterPro; IPR038275; Nuf2_N_sf.
DR Pfam; PF18595; DHR10; 1.
DR Pfam; PF03800; Nuf2; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW Kinetochore; Mitosis; Nucleus; Reference proteome.
FT CHAIN 1..462
FT /note="Probable kinetochore protein NUF2"
FT /id="PRO_0000246653"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 172..462
FT /evidence="ECO:0000255"
SQ SEQUENCE 462 AA; 54047 MW; E427723A0770E19D CRC64;
MAYNPRMSII PTSQQNSRTR KKEEEADAFM RLPDREIVGC ITDIGITFTV ADLQKPNAAH
VQQIFEWFAE LLLNATRETV EPAMRAAAED IAGEYADIIP SDTRNLMGFY VSLRRLLFEC
GITDFSFNDL YKPTYDRLVK IFSYLINFVR FRESQTAVID QHYNKAESTK TRIETLYGEN
QENEGRLEDM KRNRKAMEAQ VQQKTMRNEE LKKRLLELRR NQERVAARLE EAKQKKGELT
TALEQKTHEK VTLKQESTKL RPYVLQSASD LQENLAELRD ILNNDKSHID ALDRRARALQ
TSTDSFSVVS TDVASCIKIL DEIASELAKE EEELARNAKQ RDALSERSNN AREVERTETM
LKRQLSKWME RTEKLREQSN HKAHEAKEKM HELRAIHRQL TEEHTEKGKE MEVRRVRIEQ
TEKKMLDLKE NIENEVHSAH EEYRKMEAHI KLYIAEMEQA IA
