ID   NUF2_YARLI              Reviewed;         452 AA.
AC   Q6C3V4;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Probable kinetochore protein NUF2;
GN   Name=NUF2; OrderedLocusNames=YALI0E31867g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of NDC80, NUF2,
CC       SPC24 and SPC25. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC       kinetochore {ECO:0000250}. Note=Associated with kinetochores.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NUF2 family. {ECO:0000305}.
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DR   EMBL; CR382131; CAG80262.1; -; Genomic_DNA.
DR   RefSeq; XP_504658.1; XM_504658.1.
DR   AlphaFoldDB; Q6C3V4; -.
DR   SMR; Q6C3V4; -.
DR   STRING; 4952.CAG80262; -.
DR   PRIDE; Q6C3V4; -.
DR   EnsemblFungi; CAG80262; CAG80262; YALI0_E31867g.
DR   GeneID; 2911880; -.
DR   KEGG; yli:YALI0E31867g; -.
DR   VEuPathDB; FungiDB:YALI0_E31867g; -.
DR   HOGENOM; CLU_025461_2_0_1; -.
DR   InParanoid; Q6C3V4; -.
DR   OMA; QCDTERQ; -.
DR   Proteomes; UP000001300; Chromosome E.
DR   GO; GO:0031262; C:Ndc80 complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0044877; F:protein-containing complex binding; IBA:GO_Central.
DR   GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0051383; P:kinetochore organization; IBA:GO_Central.
DR   GO; GO:0045132; P:meiotic chromosome segregation; IBA:GO_Central.
DR   GO; GO:0007052; P:mitotic spindle organization; IBA:GO_Central.
DR   Gene3D; 1.10.418.60; -; 1.
DR   InterPro; IPR005549; Kinetochore_Nuf2_N.
DR   InterPro; IPR041112; Nuf2_DHR10-like.
DR   InterPro; IPR038275; Nuf2_N_sf.
DR   Pfam; PF18595; DHR10; 1.
DR   Pfam; PF03800; Nuf2; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..452
FT                   /note="Probable kinetochore protein NUF2"
FT                   /id="PRO_0000246656"
FT   COILED          152..280
FT                   /evidence="ECO:0000255"
FT   COILED          339..447
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   452 AA;  52702 MW;  1601E83296184139 CRC64;
     MSHMAYTPKK QVRTRNTHAA FPTLPIDEIV QCLPGLDCMV TEEELLRPTS KFVQSMYAQI
     ATSLLGINRE SMAPALAACA AGTEHPETQE DARMLFALQK PLYDLFVASG VTDYNISDIL
     KPSPERLRVQ LSAIINYARF REIREKWYEK MSEELNEEEE ARTMRLKNQE EKLRRKVELI
     ALIGDTPDQD LVEQHRINDS RKSELKRLHD QNLQLNDERE RNKAELRVVV NRLRHKHQLM
     ESLQEEVARL NSYVVDNPKN LQEEVVELSK RVKERETVRR MLGERVQKLD LSVDSFKDFQ
     VDVSSCLSAF QKLSDEQEAH SKAVRKITTQ KELLEHVGIN SRQAEGRRDV LQQEIEAAES
     KIARIQQDMS ESDRQTSRRM EELRRQIGTL DAERALVVQQ NNTAQKRLAE LENDMATERD
     RYEAQLKMAR EEAEKLQTQF REYFVEVGRR LN