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NULLO_DROME
ID   NULLO_DROME             Reviewed;         213 AA.
AC   P32845; Q9W3S9;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 4.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Protein nullo;
GN   Name=nullo; ORFNames=CG14426;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY, AND
RP   DEVELOPMENTAL STAGE.
RC   TISSUE=Embryo;
RX   PubMed=1378418; DOI=10.1101/gad.6.7.1255;
RA   Rose L.S., Wieschaus E.;
RT   "The Drosophila cellularization gene nullo produces a blastoderm-specific
RT   transcript whose levels respond to the nucleocytoplasmic ratio.";
RL   Genes Dev. 6:1255-1268(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC   -!- FUNCTION: Actin-myosin network stability during cellularization. Might
CC       be involved in increasing actin-actin interactions or membrane-to-
CC       cytoskeleton attachments. nullo together with Sry-a and bnk may provide
CC       auxiliary functions, by acting both to stabilize a large and dynamic
CC       microfilament structure and regulate its functions.
CC       {ECO:0000269|PubMed:1378418}.
CC   -!- TISSUE SPECIFICITY: Blastoderm. Throughout the entire cortex of the
CC       embryo although the distribution is not uniform.
CC       {ECO:0000269|PubMed:1378418}.
CC   -!- DEVELOPMENTAL STAGE: Appears first at nuclear cell cycle 11 and
CC       disappears rapidly as cellularization begins. During cycle 14, nullo
CC       protein levels are coupled to the nucleocytoplasmic ratio.
CC       {ECO:0000269|PubMed:1378418}.
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DR   EMBL; X65444; CAA46446.1; -; Genomic_DNA.
DR   EMBL; AE014298; AAF46238.3; -; Genomic_DNA.
DR   EMBL; AY094877; AAM11230.1; -; mRNA.
DR   PIR; A46237; A46237.
DR   RefSeq; NP_511067.3; NM_078512.5.
DR   AlphaFoldDB; P32845; -.
DR   SMR; P32845; -.
DR   STRING; 7227.FBpp0288840; -.
DR   PaxDb; P32845; -.
DR   EnsemblMetazoa; FBtr0299565; FBpp0288840; FBgn0004143.
DR   GeneID; 31652; -.
DR   KEGG; dme:Dmel_CG14426; -.
DR   UCSC; CG14426-RB; d. melanogaster.
DR   CTD; 31652; -.
DR   FlyBase; FBgn0004143; nullo.
DR   VEuPathDB; VectorBase:FBgn0004143; -.
DR   eggNOG; ENOG502TBUN; Eukaryota.
DR   HOGENOM; CLU_1220801_0_0_1; -.
DR   InParanoid; P32845; -.
DR   OMA; LRPMPRC; -.
DR   OrthoDB; 1272039at2759; -.
DR   PhylomeDB; P32845; -.
DR   BioGRID-ORCS; 31652; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 31652; -.
DR   PRO; PR:P32845; -.
DR   Proteomes; UP000000803; Chromosome X.
DR   Bgee; FBgn0004143; Expressed in cleaving embryo and 2 other tissues.
DR   Genevisible; P32845; DM.
DR   GO; GO:0005912; C:adherens junction; TAS:FlyBase.
DR   GO; GO:0005911; C:cell-cell junction; TAS:FlyBase.
DR   GO; GO:0007043; P:cell-cell junction assembly; IMP:FlyBase.
DR   GO; GO:0007349; P:cellularization; TAS:FlyBase.
DR   GO; GO:0036089; P:cleavage furrow formation; IGI:FlyBase.
DR   GO; GO:0016331; P:morphogenesis of embryonic epithelium; IMP:FlyBase.
DR   GO; GO:0008360; P:regulation of cell shape; IMP:FlyBase.
PE   2: Evidence at transcript level;
KW   Developmental protein; Reference proteome.
FT   CHAIN           1..213
FT                   /note="Protein nullo"
FT                   /id="PRO_0000057996"
FT   CONFLICT        35
FT                   /note="N -> K (in Ref. 1; CAA46446)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        138
FT                   /note="V -> A (in Ref. 1)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   213 AA;  24192 MW;  D48BEAA4DF95B2FE CRC64;
     MGSTHSAEKV KSVEDSTSPA NPGIFCTPLP GFISNIQRLV LRKLSISARK QKRLNKRSKH
     LLRPMPRCSS FGSCGTLLTP TKKSASNIAD RRYAQWKCSF EHLAQKQPRL HDISEAMTGQ
     TTPRGFPSHT DPKRCLMVMD SSSPESPLYD MVGGQKVRRR LSLRSHALVR RPSARQKAEQ
     AKLDAQFQRD LRDLEDYYGG FHFAQRRERL VKV
 
 
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