NULLO_DROME
ID NULLO_DROME Reviewed; 213 AA.
AC P32845; Q9W3S9;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 4.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Protein nullo;
GN Name=nullo; ORFNames=CG14426;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC TISSUE=Embryo;
RX PubMed=1378418; DOI=10.1101/gad.6.7.1255;
RA Rose L.S., Wieschaus E.;
RT "The Drosophila cellularization gene nullo produces a blastoderm-specific
RT transcript whose levels respond to the nucleocytoplasmic ratio.";
RL Genes Dev. 6:1255-1268(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Actin-myosin network stability during cellularization. Might
CC be involved in increasing actin-actin interactions or membrane-to-
CC cytoskeleton attachments. nullo together with Sry-a and bnk may provide
CC auxiliary functions, by acting both to stabilize a large and dynamic
CC microfilament structure and regulate its functions.
CC {ECO:0000269|PubMed:1378418}.
CC -!- TISSUE SPECIFICITY: Blastoderm. Throughout the entire cortex of the
CC embryo although the distribution is not uniform.
CC {ECO:0000269|PubMed:1378418}.
CC -!- DEVELOPMENTAL STAGE: Appears first at nuclear cell cycle 11 and
CC disappears rapidly as cellularization begins. During cycle 14, nullo
CC protein levels are coupled to the nucleocytoplasmic ratio.
CC {ECO:0000269|PubMed:1378418}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X65444; CAA46446.1; -; Genomic_DNA.
DR EMBL; AE014298; AAF46238.3; -; Genomic_DNA.
DR EMBL; AY094877; AAM11230.1; -; mRNA.
DR PIR; A46237; A46237.
DR RefSeq; NP_511067.3; NM_078512.5.
DR AlphaFoldDB; P32845; -.
DR SMR; P32845; -.
DR STRING; 7227.FBpp0288840; -.
DR PaxDb; P32845; -.
DR EnsemblMetazoa; FBtr0299565; FBpp0288840; FBgn0004143.
DR GeneID; 31652; -.
DR KEGG; dme:Dmel_CG14426; -.
DR UCSC; CG14426-RB; d. melanogaster.
DR CTD; 31652; -.
DR FlyBase; FBgn0004143; nullo.
DR VEuPathDB; VectorBase:FBgn0004143; -.
DR eggNOG; ENOG502TBUN; Eukaryota.
DR HOGENOM; CLU_1220801_0_0_1; -.
DR InParanoid; P32845; -.
DR OMA; LRPMPRC; -.
DR OrthoDB; 1272039at2759; -.
DR PhylomeDB; P32845; -.
DR BioGRID-ORCS; 31652; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 31652; -.
DR PRO; PR:P32845; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0004143; Expressed in cleaving embryo and 2 other tissues.
DR Genevisible; P32845; DM.
DR GO; GO:0005912; C:adherens junction; TAS:FlyBase.
DR GO; GO:0005911; C:cell-cell junction; TAS:FlyBase.
DR GO; GO:0007043; P:cell-cell junction assembly; IMP:FlyBase.
DR GO; GO:0007349; P:cellularization; TAS:FlyBase.
DR GO; GO:0036089; P:cleavage furrow formation; IGI:FlyBase.
DR GO; GO:0016331; P:morphogenesis of embryonic epithelium; IMP:FlyBase.
DR GO; GO:0008360; P:regulation of cell shape; IMP:FlyBase.
PE 2: Evidence at transcript level;
KW Developmental protein; Reference proteome.
FT CHAIN 1..213
FT /note="Protein nullo"
FT /id="PRO_0000057996"
FT CONFLICT 35
FT /note="N -> K (in Ref. 1; CAA46446)"
FT /evidence="ECO:0000305"
FT CONFLICT 138
FT /note="V -> A (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 213 AA; 24192 MW; D48BEAA4DF95B2FE CRC64;
MGSTHSAEKV KSVEDSTSPA NPGIFCTPLP GFISNIQRLV LRKLSISARK QKRLNKRSKH
LLRPMPRCSS FGSCGTLLTP TKKSASNIAD RRYAQWKCSF EHLAQKQPRL HDISEAMTGQ
TTPRGFPSHT DPKRCLMVMD SSSPESPLYD MVGGQKVRRR LSLRSHALVR RPSARQKAEQ
AKLDAQFQRD LRDLEDYYGG FHFAQRRERL VKV