A20A1_HUMAN
ID A20A1_HUMAN Reviewed; 823 AA.
AC Q5TYW2; Q9H0H6;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Ankyrin repeat domain-containing protein 20A1;
GN Name=ANKRD20A1; Synonyms=ANKRD20A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL136793; CAB66727.1; -; mRNA.
DR EMBL; BX649567; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS6620.1; -.
DR RefSeq; NP_115626.2; NM_032250.3.
DR AlphaFoldDB; Q5TYW2; -.
DR SMR; Q5TYW2; -.
DR BioGRID; 123947; 11.
DR IntAct; Q5TYW2; 3.
DR MINT; Q5TYW2; -.
DR STRING; 9606.ENSP00000477695; -.
DR iPTMnet; Q5TYW2; -.
DR PhosphoSitePlus; Q5TYW2; -.
DR BioMuta; ANKRD20A1; -.
DR DMDM; 74746676; -.
DR jPOST; Q5TYW2; -.
DR MassIVE; Q5TYW2; -.
DR MaxQB; Q5TYW2; -.
DR PaxDb; Q5TYW2; -.
DR PeptideAtlas; Q5TYW2; -.
DR PRIDE; Q5TYW2; -.
DR Antibodypedia; 73397; 76 antibodies from 19 providers.
DR DNASU; 84210; -.
DR Ensembl; ENST00000562196.6; ENSP00000477695.1; ENSG00000260691.7.
DR GeneID; 84210; -.
DR KEGG; hsa:84210; -.
DR MANE-Select; ENST00000562196.6; ENSP00000477695.1; NM_032250.5; NP_115626.2.
DR UCSC; uc004aeu.4; human.
DR CTD; 84210; -.
DR GeneCards; ANKRD20A1; -.
DR HGNC; HGNC:23665; ANKRD20A1.
DR HPA; ENSG00000260691; Group enriched (brain, testis).
DR neXtProt; NX_Q5TYW2; -.
DR PharmGKB; PA134953648; -.
DR VEuPathDB; HostDB:ENSG00000260691; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000163801; -.
DR HOGENOM; CLU_001111_3_0_1; -.
DR InParanoid; Q5TYW2; -.
DR OMA; NAYSETR; -.
DR OrthoDB; 294605at2759; -.
DR PhylomeDB; Q5TYW2; -.
DR TreeFam; TF333496; -.
DR PathwayCommons; Q5TYW2; -.
DR SignaLink; Q5TYW2; -.
DR BioGRID-ORCS; 84210; 47 hits in 281 CRISPR screens.
DR ChiTaRS; ANKRD20A1; human.
DR GenomeRNAi; 84210; -.
DR Pharos; Q5TYW2; Tdark.
DR PRO; PR:Q5TYW2; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q5TYW2; protein.
DR Bgee; ENSG00000260691; Expressed in sural nerve and 100 other tissues.
DR ExpressionAtlas; Q5TYW2; baseline and differential.
DR Genevisible; Q5TYW2; HS.
DR GO; GO:0005886; C:plasma membrane; IDA:LIFEdb.
DR Gene3D; 1.25.40.20; -; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR039497; CC144C-like_CC_dom.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF14915; CCDC144C; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 4.
PE 2: Evidence at transcript level;
KW ANK repeat; Coiled coil; Reference proteome; Repeat.
FT CHAIN 1..823
FT /note="Ankyrin repeat domain-containing protein 20A1"
FT /id="PRO_0000240834"
FT REPEAT 66..95
FT /note="ANK 1"
FT REPEAT 99..128
FT /note="ANK 2"
FT REPEAT 132..161
FT /note="ANK 3"
FT REPEAT 165..194
FT /note="ANK 4"
FT REPEAT 198..227
FT /note="ANK 5"
FT REGION 301..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 431..480
FT /evidence="ECO:0000255"
FT COILED 565..724
FT /evidence="ECO:0000255"
FT COILED 776..805
FT /evidence="ECO:0000255"
FT COMPBIAS 366..386
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 76
FT /note="T -> A (in Ref. 1; CAB66727)"
FT /evidence="ECO:0000305"
FT CONFLICT 128
FT /note="L -> F (in Ref. 1; CAB66727)"
FT /evidence="ECO:0000305"
FT CONFLICT 499
FT /note="W -> R (in Ref. 1; CAB66727)"
FT /evidence="ECO:0000305"
FT CONFLICT 679
FT /note="R -> C (in Ref. 1; CAB66727)"
FT /evidence="ECO:0000305"
FT CONFLICT 772
FT /note="G -> E (in Ref. 1; CAB66727)"
FT /evidence="ECO:0000305"
FT CONFLICT 805
FT /note="E -> G (in Ref. 1; CAB66727)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 823 AA; 94048 MW; 0AE8585829E6E91B CRC64;
MKLFGFGSRR GQTAQGSIDH VYTGSGYRIR DSELQKIHRA AVKGDAAEVE RCLARRSGDL
DALDKQHRTA LHLACTSGHV QVVTLLVNRK CQIDVCDKEN RTPLIQAVHC QEEACAVILL
EHGANPNLKD IYGNTALHYA VYSESTSLAE KLLSHGAHIE ALDKDNNTPL LFAIICKKEK
MVEFLLKKKA SSHAVDRLRR SALMLAVYYD SPGIVNILLK QNIDVFAQDM CGRDAEDYAI
SHHLTKIQQQ ILEHKKKILK KEKSDVGSSD ESAVSIFHEL RVDSLPASDD KDLNVATKQC
VPEKVSEPLP GSSHEKGNRI VNGQGEGPPA KHPSLKPSTE VEDPAVKGAV QRKNVQTLRA
EQALPVASEE EQERHERSEK KQPQVKEGNN TNKSEKIQLS ENICDSTSSA AAGRLTQQRK
IGKTYPQQFP KKLKEEHDRC TLKQENEEKT NVNMLYKKNR EELERKEKQY KKEVEAKQLE
PTVQSLEMKS KTARNTPNWD FHNHEEMKGL MDENCILKAD IAILRQEICT MKNDNLEKEN
KYLKDIKIVK ETNAALEKYI KLNEEMITET AFRYQQELND LKAENTRLNA ELLKEKESKK
RLEADIESYQ SRLAAAISKH SESVKTERNL KLALERTRDV SVQVEMSSAI SKVKAENEFL
TEQLSETQIK FNALKDKFRK TRDSLRKKSL ALETVQNDLS QTQQQTQEMK EMYQNAEAKV
NNSTGKWNCV EERICHLQRE NAWLVQQLDD VHQKEDHKEI VTNIQRGFIE SGKKDLVLEE
KSKKLMNECD HLKESLFQYE REKTEGVVSI KEDKYFQTSR KTI
