ID   A20A2_HUMAN             Reviewed;         823 AA.
AC   Q5SQ80;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Putative ankyrin repeat domain-containing protein 20A2;
DE   AltName: Full=Ankyrin repeat domain-containing protein 20A2 pseudogene {ECO:0000312|HGNC:HGNC:31979};
GN   Name=ANKRD20A2P {ECO:0000312|HGNC:HGNC:31979}; Synonyms=ANKRD20A2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL773545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX664727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001012421.1; NM_001012421.1.
DR   AlphaFoldDB; Q5SQ80; -.
DR   SMR; Q5SQ80; -.
DR   BioGRID; 137462; 6.
DR   IntAct; Q5SQ80; 1.
DR   STRING; 9606.ENSP00000366826; -.
DR   iPTMnet; Q5SQ80; -.
DR   PhosphoSitePlus; Q5SQ80; -.
DR   BioMuta; ANKRD20A2; -.
DR   DMDM; 74743522; -.
DR   EPD; Q5SQ80; -.
DR   jPOST; Q5SQ80; -.
DR   MassIVE; Q5SQ80; -.
DR   MaxQB; Q5SQ80; -.
DR   PaxDb; Q5SQ80; -.
DR   PeptideAtlas; Q5SQ80; -.
DR   PRIDE; Q5SQ80; -.
DR   Antibodypedia; 71388; 3 antibodies from 2 providers.
DR   Ensembl; ENST00000377601.3; ENSP00000366826.2; ENSG00000183148.7.
DR   UCSC; uc004acd.4; human.
DR   GeneCards; ANKRD20A2P; -.
DR   HGNC; HGNC:31979; ANKRD20A2P.
DR   HPA; ENSG00000183148; Tissue enhanced (brain, testis).
DR   neXtProt; NX_Q5SQ80; -.
DR   VEuPathDB; HostDB:ENSG00000183148; -.
DR   eggNOG; KOG0504; Eukaryota.
DR   GeneTree; ENSGT00940000163801; -.
DR   HOGENOM; CLU_001111_3_0_1; -.
DR   InParanoid; Q5SQ80; -.
DR   OMA; TKTAFQY; -.
DR   OrthoDB; 294605at2759; -.
DR   PhylomeDB; Q5SQ80; -.
DR   TreeFam; TF333496; -.
DR   PathwayCommons; Q5SQ80; -.
DR   BioGRID-ORCS; 441430; 354 hits in 548 CRISPR screens.
DR   GenomeRNAi; 441430; -.
DR   Pharos; Q5SQ80; Tdark.
DR   PRO; PR:Q5SQ80; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q5SQ80; protein.
DR   Bgee; ENSG00000183148; Expressed in sural nerve and 101 other tissues.
DR   ExpressionAtlas; Q5SQ80; baseline and differential.
DR   Genevisible; Q5SQ80; HS.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR039497; CC144C-like_CC_dom.
DR   Pfam; PF12796; Ank_2; 2.
DR   Pfam; PF14915; CCDC144C; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 6.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 4.
PE   5: Uncertain;
KW   ANK repeat; Coiled coil; Reference proteome; Repeat.
FT   CHAIN           1..823
FT                   /note="Putative ankyrin repeat domain-containing protein
FT                   20A2"
FT                   /id="PRO_0000240837"
FT   REPEAT          66..95
FT                   /note="ANK 1"
FT   REPEAT          99..128
FT                   /note="ANK 2"
FT   REPEAT          132..161
FT                   /note="ANK 3"
FT   REPEAT          165..194
FT                   /note="ANK 4"
FT   REPEAT          198..227
FT                   /note="ANK 5"
FT   REGION          301..343
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          355..402
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          431..480
FT                   /evidence="ECO:0000255"
FT   COILED          565..724
FT                   /evidence="ECO:0000255"
FT   COILED          776..805
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        366..386
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        387..402
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   823 AA;  94087 MW;  6C1C478C3EE9B67F CRC64;
     MKLFGFGSRR GQTAQGSIDH VYTGSGYRIR DSELQKIHRA AVKGDAAEVE RCLARRSGDL
     DALDKQHRTA LHLACASGHV QVVTLLVNRK CQIDVCDKEN RTPLIQAVHC QEEACAVILL
     EHGANPNLKD IYGNTALHYA VYSESTSLAE KLLSHGAHIE ALDKDNNTPL LFAIICKKEK
     MVEFLLKRKA SSHAVDRLRR SALMLAVYYD SPGIVNILLK QNIDVFAQDM CGRDAEDYAI
     SHHLTKIQQQ ILEHKKKILK KEKSDVGSSD ESAVSIFHEL RVDSLPASDD KDLNVATKQC
     VPEKVSEPLP GSSHEKGNRI VNGQGEGPPA KHPSLKPSTE VEDPAVKGAV QRKNVQTLRA
     EQALPVASEE EQERHERSEK KQPQVKEGNN TNKSEKIQLS ENICDSTSSA AAGRLTQQRK
     IGKTYPQQFP KKLKEEHDRC TLKQENEEKT NVNMLYKKNR EELERKEKQY KKEVEAKQLE
     PTVQSLEMKS KTARNTPNRD FHNHEEMKGL MDENCILKAD IAILRQEICT MKNDNLEKEN
     KYLKDIKIVK ETNAALEKYI KLNEEMITET AFRYQQELND LKAENTRLNA ELLKEKESKK
     RLEADIESYQ SRLAAAISKH SESVKTERNL KLALERTRDV SVQVEMSSAI SKVKDENEFL
     TEQLSETQIK FNALKDKFRK TRDSLRKKSL ALETVQNDLS QTQQQTQEMK EMYQNAEAKV
     NNSTGKWNCV EERICHLQRE NAWLVQQLDD VHQKEDHKEI VTNIQRGFIE SGKKDLVLEE
     KSKKLMNECD HLKESLFQYE REKTEGVVSI KEDKYFQTSR KKI