ID   A20A3_HUMAN             Reviewed;         823 AA.
AC   Q5VUR7;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Putative ankyrin repeat domain-containing protein 20A3;
DE   AltName: Full=Ankyrin repeat domain-containing protein 20A3 pseudogene {ECO:0000312|HGNC:HGNC:31981};
GN   Name=ANKRD20A3P {ECO:0000312|HGNC:HGNC:31981}; Synonyms=ANKRD20A3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL513478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001012419.1; NM_001012419.2.
DR   AlphaFoldDB; Q5VUR7; -.
DR   SMR; Q5VUR7; -.
DR   BioGRID; 137457; 1.
DR   IntAct; Q5VUR7; 1.
DR   STRING; 9606.ENSP00000482325; -.
DR   iPTMnet; Q5VUR7; -.
DR   PhosphoSitePlus; Q5VUR7; -.
DR   BioMuta; ANKRD20A3; -.
DR   DMDM; 74747147; -.
DR   EPD; Q5VUR7; -.
DR   jPOST; Q5VUR7; -.
DR   MassIVE; Q5VUR7; -.
DR   MaxQB; Q5VUR7; -.
DR   PaxDb; Q5VUR7; -.
DR   PeptideAtlas; Q5VUR7; -.
DR   PRIDE; Q5VUR7; -.
DR   Antibodypedia; 72885; 149 antibodies from 23 providers.
DR   DNASU; 441425; -.
DR   Ensembl; ENST00000611388.1; ENSP00000482325.1; ENSG00000276203.5.
DR   UCSC; uc033cut.1; human.
DR   GeneCards; ANKRD20A3P; -.
DR   HGNC; HGNC:31981; ANKRD20A3P.
DR   HPA; ENSG00000276203; Tissue enhanced (testis).
DR   neXtProt; NX_Q5VUR7; -.
DR   VEuPathDB; HostDB:ENSG00000276203; -.
DR   eggNOG; KOG0504; Eukaryota.
DR   GeneTree; ENSGT00940000163801; -.
DR   HOGENOM; CLU_001111_3_0_1; -.
DR   InParanoid; Q5VUR7; -.
DR   OMA; NIQGDFI; -.
DR   OrthoDB; 294605at2759; -.
DR   PhylomeDB; Q5VUR7; -.
DR   TreeFam; TF333496; -.
DR   PathwayCommons; Q5VUR7; -.
DR   BioGRID-ORCS; 441425; 22 hits in 252 CRISPR screens.
DR   GenomeRNAi; 441425; -.
DR   Pharos; Q5VUR7; Tdark.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q5VUR7; protein.
DR   Bgee; ENSG00000276203; Expressed in sural nerve and 97 other tissues.
DR   ExpressionAtlas; Q5VUR7; baseline and differential.
DR   Genevisible; Q5VUR7; HS.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR039497; CC144C-like_CC_dom.
DR   Pfam; PF12796; Ank_2; 2.
DR   Pfam; PF14915; CCDC144C; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 6.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 4.
PE   5: Uncertain;
KW   ANK repeat; Coiled coil; Reference proteome; Repeat.
FT   CHAIN           1..823
FT                   /note="Putative ankyrin repeat domain-containing protein
FT                   20A3"
FT                   /id="PRO_0000240836"
FT   REPEAT          66..95
FT                   /note="ANK 1"
FT   REPEAT          99..128
FT                   /note="ANK 2"
FT   REPEAT          132..161
FT                   /note="ANK 3"
FT   REPEAT          165..194
FT                   /note="ANK 4"
FT   REPEAT          198..227
FT                   /note="ANK 5"
FT   REGION          301..343
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          355..402
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          431..480
FT                   /evidence="ECO:0000255"
FT   COILED          571..724
FT                   /evidence="ECO:0000255"
FT   COILED          776..805
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        366..386
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        387..402
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   823 AA;  94108 MW;  CC0ED7895CA092E4 CRC64;
     MKLFGFGSRR GQTAQGSIDH VYTGSGYRIR DSELQKIHRA AVKGDAAEVE RCLARRSGDL
     DALDKQHRTA LHLACASGHV QVVTLLVNRK CQIDVCDKEN RTPLIQAVHC QEEACAVILL
     EHGANPNLKD IYGNTALHYA VYSESTSLAE KLLSHGAHIE ALDKDNNTPL LFAIICKKEK
     MVEFLLKRKA SSHAVDRLRR SALMLAVYYD SPGIVNILLK QNIDVFAQDM CGRDAEDYAI
     SHHLTKIQQQ ILEHKKKILK KEKSDVGSSD ESAVSIFHEL RVDSLPASDD KDLNVATKQC
     VPEKVSEPLP GSSHEKGNRI VNGQGEGPPA KHPSLKPSTE VEDPAVKGAV QRKNVQTLRA
     EQALPVASEE EQERHERSEK KQPQVKEGNN TNKSEKIQLS ENICDSTSSA AAGRLTQQRK
     IGKTYPQQFP KKLKEEHDRC TLKQENEEKT NVNMLYKKNR EELERKEKQY KKEVEAKQLE
     PTVQSLEMKS KTARNTPNRD FHNHEEMKGL MDENCILKAD IAILRQEICT MKNDNLEKEN
     KYLKDIKIVK ETNAALEKYI KLNEEMITET AFRYQQELNY LKAENTRLNA ELLKEKESKK
     RLEADIESYQ SRLAAAISKH SESVKTERNL KLALERTRDV SVQVEMSSAI SKVKDENEFL
     TEQLSETQIK FNALKDKFRK TRDSLRKKSL ALETVQNDLS QTQQQTQEMK EMYQNAEAKV
     NNSTGKWNCV EERICHLQRE NAWLVQQLDD VHQKEDHKEI VTNIQRGFIE SGKKDLVLEE
     KSKKLMNECD HLKESLFQYE REKTEGVVSI KEDKYFQTSR KTI