ID   A20A4_HUMAN             Reviewed;         823 AA.
AC   Q4UJ75;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Putative ankyrin repeat domain-containing protein 20A4;
DE   AltName: Full=Ankyrin repeat domain-containing protein 20A4 pseudogene {ECO:0000312|HGNC:HGNC:31982};
GN   Name=ANKRD20A4P {ECO:0000312|HGNC:HGNC:31982}; Synonyms=ANKRD20A4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; CR769776; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001092275.1; NM_001098805.1.
DR   AlphaFoldDB; Q4UJ75; -.
DR   SMR; Q4UJ75; -.
DR   BioGRID; 609165; 4.
DR   IntAct; Q4UJ75; 1.
DR   STRING; 9606.ENSP00000349891; -.
DR   iPTMnet; Q4UJ75; -.
DR   PhosphoSitePlus; Q4UJ75; -.
DR   BioMuta; ANKRD20A4; -.
DR   DMDM; 74753541; -.
DR   jPOST; Q4UJ75; -.
DR   MassIVE; Q4UJ75; -.
DR   MaxQB; Q4UJ75; -.
DR   PaxDb; Q4UJ75; -.
DR   PeptideAtlas; Q4UJ75; -.
DR   PRIDE; Q4UJ75; -.
DR   Antibodypedia; 71431; 4 antibodies from 4 providers.
DR   Ensembl; ENST00000357336.3; ENSP00000349891.3; ENSG00000172014.12.
DR   UCSC; uc004afn.4; human.
DR   GeneCards; ANKRD20A4P; -.
DR   HGNC; HGNC:31982; ANKRD20A4P.
DR   HPA; ENSG00000172014; Tissue enhanced (brain).
DR   neXtProt; NX_Q4UJ75; -.
DR   VEuPathDB; HostDB:ENSG00000172014; -.
DR   eggNOG; KOG0504; Eukaryota.
DR   GeneTree; ENSGT00940000163801; -.
DR   HOGENOM; CLU_001111_3_0_1; -.
DR   InParanoid; Q4UJ75; -.
DR   OMA; LIMASEY; -.
DR   OrthoDB; 294605at2759; -.
DR   PhylomeDB; Q4UJ75; -.
DR   TreeFam; TF333496; -.
DR   PathwayCommons; Q4UJ75; -.
DR   SignaLink; Q4UJ75; -.
DR   BioGRID-ORCS; 728747; 23 hits in 206 CRISPR screens.
DR   GenomeRNAi; 728747; -.
DR   Pharos; Q4UJ75; Tdark.
DR   PRO; PR:Q4UJ75; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q4UJ75; protein.
DR   Bgee; ENSG00000172014; Expressed in lower esophagus mucosa and 96 other tissues.
DR   ExpressionAtlas; Q4UJ75; baseline and differential.
DR   Genevisible; Q4UJ75; HS.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR039497; CC144C-like_CC_dom.
DR   Pfam; PF12796; Ank_2; 2.
DR   Pfam; PF14915; CCDC144C; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 6.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 4.
PE   5: Uncertain;
KW   ANK repeat; Coiled coil; Reference proteome; Repeat.
FT   CHAIN           1..823
FT                   /note="Putative ankyrin repeat domain-containing protein
FT                   20A4"
FT                   /id="PRO_0000240835"
FT   REPEAT          66..95
FT                   /note="ANK 1"
FT   REPEAT          99..128
FT                   /note="ANK 2"
FT   REPEAT          132..161
FT                   /note="ANK 3"
FT   REPEAT          165..194
FT                   /note="ANK 4"
FT   REPEAT          198..227
FT                   /note="ANK 5"
FT   REGION          301..343
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          356..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          431..480
FT                   /evidence="ECO:0000255"
FT   COILED          565..724
FT                   /evidence="ECO:0000255"
FT   COILED          776..806
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        368..386
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        387..405
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   823 AA;  94149 MW;  597B760D5733208A CRC64;
     MKLFGFGSRR GQTAQGSIDH VYTGSGYRIR DSELQKIHRA AVKGDAAEVE RCLARRSGEL
     DALDKQHRTA LHLACASGHV QVVTLLVNRK CQIDVCDKEN RTPLIQAVHC QEEACAVILL
     EHGANPNLKD IYGNTALHYA VYSESTSLAE KLLSHGAHIE ALDKDNNTPL LFAIICKKEK
     MVEFLLKKKA SSHAVDRLRR SALMLAVYYD SPGIVNILLK QNIDVFAQDM CGRDAEDYAI
     SHHLTKIQQQ ILEHKKKILK KEKSDVGSSD ESAVSIFHEL RVDSLPASDD KDLNVATKQC
     VPEKVSEPLP GSSHEKGNRI VNGQGEGPPA KHPSLKPSTE VEDPAVKGAV QRKNVQTLRA
     EQALPVASEE EQQRHERSEK KQPQVKEGNN TNKSEKIQLS ENICDSTSSA AAGRLTQQRK
     IGKTYPQQFP KKLKEEHDRC TLKQENEEKT NVNMLYKKNR EELERKEKQY KKEVEAKQLE
     PTVQSLEMKS KTARNTPNWD FHNHEEMKGL MDENCILKAD IAILRQEICT MKNDNLEKEN
     KYLKDIKIVK ETNAALEKYI KLNEEMITET AFRYQQELND LKAENTRLNA ELLKEKESKK
     RLEADIESYQ SRLAAAISKH SESVKTERNL KLALERTQDV SVQVEMSSAI SKVKDENEFL
     TEQLSETQIK FNALKDKFRK TRDSLRKKSL ALETVQNNLS QTQQQTQEMK EMYQNAEAKV
     NNSTGKWNCV EERICHLQRE NAWLVQQLDD VHQKEDHKEI VTNIQRGFIE SGKKDFVLEE
     KSKKLMNECD HLKESLFQYE REKTEVVVSI KEDKYFQTSR KKI