ID   AROS_BOVIN              Reviewed;         137 AA.
AC   A6H7J2;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Active regulator of SIRT1;
DE   AltName: Full=40S ribosomal protein S19-binding protein 1;
DE            Short=RPS19-binding protein 1;
DE            Short=S19BP;
GN   Name=RPS19BP1; Synonyms=AROS;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal cerebellum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Direct regulator of SIRT1. Enhances SIRT1-mediated
CC       deacetylation of p53/TP53, thereby participating in inhibition of
CC       p53/TP53-mediated transcriptional activity (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with RPS19. Interacts with SIRT1 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- PTM: Citrullinated by PADI4. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AROS family. {ECO:0000305}.
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DR   EMBL; BC146267; AAI46268.1; -; mRNA.
DR   RefSeq; NP_001092386.1; NM_001098916.2.
DR   AlphaFoldDB; A6H7J2; -.
DR   SMR; A6H7J2; -.
DR   STRING; 9913.ENSBTAP00000023214; -.
DR   PaxDb; A6H7J2; -.
DR   PRIDE; A6H7J2; -.
DR   Ensembl; ENSBTAT00000023214; ENSBTAP00000023214; ENSBTAG00000017463.
DR   GeneID; 509108; -.
DR   KEGG; bta:509108; -.
DR   CTD; 91582; -.
DR   VEuPathDB; HostDB:ENSBTAG00000017463; -.
DR   VGNC; VGNC:34132; RPS19BP1.
DR   eggNOG; ENOG502S1CM; Eukaryota.
DR   GeneTree; ENSGT00390000016774; -.
DR   HOGENOM; CLU_152637_0_0_1; -.
DR   InParanoid; A6H7J2; -.
DR   OMA; KFQREYF; -.
DR   OrthoDB; 1513987at2759; -.
DR   TreeFam; TF333429; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000017463; Expressed in ileocecal valve and 107 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0019899; F:enzyme binding; IBA:GO_Central.
DR   InterPro; IPR023262; AROS.
DR   PANTHER; PTHR31454; PTHR31454; 1.
DR   Pfam; PF15684; AROS; 1.
DR   PRINTS; PR02029; ACTREGSIRT1.
PE   2: Evidence at transcript level;
KW   Citrullination; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..137
FT                   /note="Active regulator of SIRT1"
FT                   /id="PRO_0000361537"
FT   REGION          14..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          96..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         7
FT                   /note="Citrulline"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         84
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86WX3"
SQ   SEQUENCE   137 AA;  15367 MW;  4959D30D90B154A9 CRC64;
     MSAALLRRGL ELLGAPEAPG AAPGHTKPSQ APMKRTRKAK ATQAQKLRNS AKGKVPKSAL
     AEFRKKERRG YLGVNLRFMT SARSTVDESV TRQIMRQNRG RKACDRPVTK TKKKKKAEGT
     VFTEEDFQKF QREYFGS