AROS_MOUSE
ID AROS_MOUSE Reviewed; 143 AA.
AC Q8C6B9; Q2WFQ7;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Active regulator of SIRT1;
DE AltName: Full=40S ribosomal protein S19-binding protein 1;
DE Short=RPS19-binding protein 1;
DE Short=S19BP;
GN Name=Rps19bp1; Synonyms=Aros;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, INTERACTION WITH RPS19, AND VARIANT LYS-116 DEL.
RX PubMed=16289379; DOI=10.1016/j.bbrc.2005.10.184;
RA Maeda N., Toku S., Kenmochi N., Tanaka T.;
RT "A novel nucleolar protein interacts with ribosomal protein S19.";
RL Biochem. Biophys. Res. Commun. 339:41-46(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Liver;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Pancreas, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP CITRULLINATION AT ARG-7.
RX PubMed=24463520; DOI=10.1038/nature12942;
RA Christophorou M.A., Castelo-Branco G., Halley-Stott R.P., Oliveira C.S.,
RA Loos R., Radzisheuskaya A., Mowen K.A., Bertone P., Silva J.C.,
RA Zernicka-Goetz M., Nielsen M.L., Gurdon J.B., Kouzarides T.;
RT "Citrullination regulates pluripotency and histone H1 binding to
RT chromatin.";
RL Nature 507:104-108(2014).
CC -!- FUNCTION: Direct regulator of SIRT1. Enhances SIRT1-mediated
CC deacetylation of p53/TP53, thereby participating in inhibition of
CC p53/TP53-mediated transcriptional activity (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with SIRT1 (By similarity). Interacts with RPS19.
CC {ECO:0000250, ECO:0000269|PubMed:16289379}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16289379}.
CC -!- TISSUE SPECIFICITY: Widely expressed with higher levels in submaxillary
CC gland and epididymis. {ECO:0000269|PubMed:16289379}.
CC -!- PTM: Citrullinated by PADI4. {ECO:0000269|PubMed:24463520}.
CC -!- SIMILARITY: Belongs to the AROS family. {ECO:0000305}.
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DR EMBL; AB233218; BAE53365.1; -; mRNA.
DR EMBL; AB233219; BAE53366.1; -; Genomic_DNA.
DR EMBL; AK075974; BAC36088.1; -; mRNA.
DR EMBL; BC038691; AAH38691.1; -; mRNA.
DR EMBL; BC050115; AAH50115.1; -; mRNA.
DR CCDS; CCDS27662.1; -.
DR RefSeq; NP_780318.1; NM_175109.3.
DR AlphaFoldDB; Q8C6B9; -.
DR SMR; Q8C6B9; -.
DR BioGRID; 211544; 5.
DR IntAct; Q8C6B9; 1.
DR MINT; Q8C6B9; -.
DR STRING; 10090.ENSMUSP00000061167; -.
DR iPTMnet; Q8C6B9; -.
DR PhosphoSitePlus; Q8C6B9; -.
DR EPD; Q8C6B9; -.
DR MaxQB; Q8C6B9; -.
DR PaxDb; Q8C6B9; -.
DR PeptideAtlas; Q8C6B9; -.
DR PRIDE; Q8C6B9; -.
DR ProteomicsDB; 283229; -.
DR Antibodypedia; 51530; 139 antibodies from 25 providers.
DR DNASU; 66538; -.
DR Ensembl; ENSMUST00000052499; ENSMUSP00000061167; ENSMUSG00000051518.
DR GeneID; 66538; -.
DR KEGG; mmu:66538; -.
DR UCSC; uc007wvm.1; mouse.
DR CTD; 91582; -.
DR MGI; MGI:1913788; Rps19bp1.
DR VEuPathDB; HostDB:ENSMUSG00000051518; -.
DR eggNOG; ENOG502S1CM; Eukaryota.
DR GeneTree; ENSGT00390000016774; -.
DR HOGENOM; CLU_152637_0_0_1; -.
DR InParanoid; Q8C6B9; -.
DR OMA; KFQREYF; -.
DR OrthoDB; 1513987at2759; -.
DR PhylomeDB; Q8C6B9; -.
DR TreeFam; TF333429; -.
DR Reactome; R-MMU-3371453; Regulation of HSF1-mediated heat shock response.
DR BioGRID-ORCS; 66538; 16 hits in 72 CRISPR screens.
DR ChiTaRS; Rps19bp1; mouse.
DR PRO; PR:Q8C6B9; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q8C6B9; protein.
DR Bgee; ENSMUSG00000051518; Expressed in dorsal pancreas and 229 other tissues.
DR ExpressionAtlas; Q8C6B9; baseline and differential.
DR Genevisible; Q8C6B9; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; IDA:HGNC-UCL.
DR GO; GO:0005654; C:nucleoplasm; IDA:HGNC-UCL.
DR GO; GO:0019899; F:enzyme binding; ISO:MGI.
DR InterPro; IPR023262; AROS.
DR PANTHER; PTHR31454; PTHR31454; 1.
DR Pfam; PF15684; AROS; 1.
DR PRINTS; PR02029; ACTREGSIRT1.
PE 1: Evidence at protein level;
KW Citrullination; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..143
FT /note="Active regulator of SIRT1"
FT /id="PRO_0000252394"
FT REGION 20..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 7
FT /note="Citrulline"
FT /evidence="ECO:0000269|PubMed:24463520"
FT MOD_RES 86
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86WX3"
FT VARIANT 116
FT /note="Missing"
FT /evidence="ECO:0000269|PubMed:16289379"
SQ SEQUENCE 143 AA; 15978 MW; 6EBBF45EE0668116 CRC64;
MSAALVRRGL ELLAASEAPR AVPGQVQASG TPAKRTRRAR AKASQALKLR NSAKGKAPKS
ALAEYQKRQC RDHLKANLKF MTSMRSTVPE SVTQQILQQN QGRKACDRLV AKTKNKKKKK
KKAEGTVFTE EDFQKFQREY FGS
