ARP10_HUMAN
ID ARP10_HUMAN Reviewed; 417 AA.
AC Q9NZ32; Q9H9Y5; Q9NWY2;
DT 27-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Actin-related protein 10;
DE AltName: Full=Actin-related protein 11;
DE Short=hARP11;
GN Name=ACTR10; Synonyms=ACTR11, ARP10, ARP11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hypothalamus;
RX PubMed=10931946; DOI=10.1073/pnas.160270997;
RA Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X.,
RA Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W.,
RA Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., Xu S.-H., Gu J.,
RA Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z.,
RA Chen M.-D., Chen J.-L.;
RT "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis
RT and full-length cDNA cloning.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- INTERACTION:
CC Q9NZ32; Q9UJW0: DCTN4; NbExp=3; IntAct=EBI-2559426, EBI-2134033;
CC Q9NZ32; Q15323: KRT31; NbExp=3; IntAct=EBI-2559426, EBI-948001;
CC Q9NZ32; Q9UJ70: NAGK; NbExp=3; IntAct=EBI-2559426, EBI-372578;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR EMBL; AF220190; AAF67655.1; -; mRNA.
DR EMBL; AK000544; BAA91243.1; -; mRNA.
DR EMBL; AK022534; BAB14083.1; -; mRNA.
DR EMBL; BC011997; AAH11997.1; -; mRNA.
DR CCDS; CCDS32090.1; -.
DR RefSeq; NP_060947.1; NM_018477.2.
DR AlphaFoldDB; Q9NZ32; -.
DR SMR; Q9NZ32; -.
DR BioGRID; 120962; 99.
DR IntAct; Q9NZ32; 45.
DR MINT; Q9NZ32; -.
DR STRING; 9606.ENSP00000254286; -.
DR GlyGen; Q9NZ32; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9NZ32; -.
DR MetOSite; Q9NZ32; -.
DR PhosphoSitePlus; Q9NZ32; -.
DR SwissPalm; Q9NZ32; -.
DR BioMuta; ACTR10; -.
DR DMDM; 27923739; -.
DR EPD; Q9NZ32; -.
DR jPOST; Q9NZ32; -.
DR MassIVE; Q9NZ32; -.
DR MaxQB; Q9NZ32; -.
DR PaxDb; Q9NZ32; -.
DR PeptideAtlas; Q9NZ32; -.
DR PRIDE; Q9NZ32; -.
DR ProteomicsDB; 83317; -.
DR Antibodypedia; 24149; 99 antibodies from 23 providers.
DR DNASU; 55860; -.
DR Ensembl; ENST00000254286.9; ENSP00000254286.4; ENSG00000131966.14.
DR GeneID; 55860; -.
DR KEGG; hsa:55860; -.
DR MANE-Select; ENST00000254286.9; ENSP00000254286.4; NM_018477.3; NP_060947.1.
DR UCSC; uc001xdf.4; human.
DR CTD; 55860; -.
DR DisGeNET; 55860; -.
DR GeneCards; ACTR10; -.
DR HGNC; HGNC:17372; ACTR10.
DR HPA; ENSG00000131966; Low tissue specificity.
DR MIM; 619731; gene.
DR neXtProt; NX_Q9NZ32; -.
DR OpenTargets; ENSG00000131966; -.
DR PharmGKB; PA134899463; -.
DR VEuPathDB; HostDB:ENSG00000131966; -.
DR eggNOG; KOG0676; Eukaryota.
DR GeneTree; ENSGT00910000144250; -.
DR HOGENOM; CLU_027965_2_1_1; -.
DR InParanoid; Q9NZ32; -.
DR OMA; RVLFVHF; -.
DR OrthoDB; 964605at2759; -.
DR PhylomeDB; Q9NZ32; -.
DR TreeFam; TF315151; -.
DR PathwayCommons; Q9NZ32; -.
DR Reactome; R-HSA-2132295; MHC class II antigen presentation.
DR Reactome; R-HSA-3371497; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand.
DR Reactome; R-HSA-6798695; Neutrophil degranulation.
DR Reactome; R-HSA-6807878; COPI-mediated anterograde transport.
DR Reactome; R-HSA-6811436; COPI-independent Golgi-to-ER retrograde traffic.
DR SignaLink; Q9NZ32; -.
DR BioGRID-ORCS; 55860; 746 hits in 1074 CRISPR screens.
DR ChiTaRS; ACTR10; human.
DR GenomeRNAi; 55860; -.
DR Pharos; Q9NZ32; Tbio.
DR PRO; PR:Q9NZ32; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q9NZ32; protein.
DR Bgee; ENSG00000131966; Expressed in secondary oocyte and 200 other tissues.
DR ExpressionAtlas; Q9NZ32; baseline and differential.
DR Genevisible; Q9NZ32; HS.
DR GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR GO; GO:0035578; C:azurophil granule lumen; TAS:Reactome.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005869; C:dynactin complex; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:1904813; C:ficolin-1-rich granule lumen; TAS:Reactome.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR GO; GO:0098958; P:retrograde axonal transport of mitochondrion; IBA:GO_Central.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR027127; Arp10.
DR InterPro; IPR043129; ATPase_NBD.
DR PANTHER; PTHR11937; PTHR11937; 1.
DR PANTHER; PTHR11937:SF14; PTHR11937:SF14; 1.
DR Pfam; PF00022; Actin; 2.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..417
FT /note="Actin-related protein 10"
FT /id="PRO_0000089131"
FT CONFLICT 53
FT /note="R -> K (in Ref. 2; BAA91243)"
FT /evidence="ECO:0000305"
FT CONFLICT 93
FT /note="E -> K (in Ref. 2; BAA91243)"
FT /evidence="ECO:0000305"
FT CONFLICT 219
FT /note="D -> G (in Ref. 2; BAB14083)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 417 AA; 46307 MW; DF351A7B299DB7C1 CRC64;
MPLYEGLGSG GEKTAVVIDL GEAFTKCGFA GETGPRCIIP SVIKRAGMPK PVRVVQYNIN
TEELYSYLKE FIHILYFRHL LVNPRDRRVV IIESVLCPSH FRETLTRVLF KYFEVPSVLL
APSHLMALLT LGINSAMVLD CGYRESLVLP IYEGIPVLNC WGALPLGGKA LHKELETQLL
EQCTVDTSVA KEQSLPSVMG SVPEGVLEDI KARTCFVSDL KRGLKIQAAK FNIDGNNERP
SPPPNVDYPL DGEKILHILG SIRDSVVEIL FEQDNEEQSV ATLILDSLIQ CPIDTRKQLA
ENLVVIGGTS MLPGFLHRLL AEIRYLVEKP KYKKALGTKT FRIHTPPAKA NCVAWLGGAI
FGALQDILGS RSVSKEYYNQ TGRIPDWCSL NNPPLEMMFD VGKTQPPLMK RAFSTEK
