ARP10_YEAST
ID ARP10_YEAST Reviewed; 284 AA.
AC Q04549; D6VS92; Q03869;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Actin-like protein ARP10;
GN Name=ARP10; OrderedLocusNames=YDR106W; ORFNames=YD8557.15, YD9727.02;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP GENE NAME.
RX PubMed=9290209;
RX DOI=10.1002/(sici)1097-0061(19970915)13:11<1053::aid-yea164>3.0.co;2-4;
RA Poch O., Winsor B.;
RT "Who's who among the Saccharomyces cerevisiae actin-related proteins? A
RT classification and nomenclature proposal for a large family.";
RL Yeast 13:1053-1058(1997).
RN [5]
RP FUNCTION, SELF-ASSOCIATION, INTERACTION WITH ARP1 AND JNM1, AND
RP IDENTIFICATION IN THE DYNACTIN COMPLEX.
RX PubMed=16291862; DOI=10.1091/mbc.e05-05-0449;
RA Clark S.W., Rose M.D.;
RT "Arp10p is a pointed-end-associated component of yeast dynactin.";
RL Mol. Biol. Cell 17:738-748(2006).
CC -!- FUNCTION: Pointed-end-associated component of the dynactin complex
CC which assists cytoplasmic dynein by increasing its processivity and by
CC regulation of its cargo binding (By similarity). The dynactin complex
CC is required for the spindle translocation late in anaphase and is
CC involved in a cell wall synthesis checkpoint. May regulate the
CC association of the dynactin complex with the plasma membrane.
CC {ECO:0000250, ECO:0000269|PubMed:16291862}.
CC -!- SUBUNIT: Self-associates. Component of the dynactin complex composed of
CC at least ARP1, JNM1, NIP100 and ARP10. Dynactin comprises a short rod
CC of the ARP1 filament attached to ARP10 at its pointed-end and probably
CC associated with the capping protein at its barbed-end. The rod is
CC implicated in dynein cargo binding. A sidearm formed by NIP100 projects
CC from the ARP1 filament and is implicated in motor binding (By
CC similarity). Interacts with ARP1 and JNM1. {ECO:0000250,
CC ECO:0000269|PubMed:16291862}.
CC -!- INTERACTION:
CC Q04549; P38696: ARP1; NbExp=5; IntAct=EBI-2977, EBI-2920;
CC Q04549; P36224: JNM1; NbExp=3; IntAct=EBI-2977, EBI-9415;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the actin family. ARP10 subfamily.
CC {ECO:0000305}.
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DR EMBL; Z48758; CAA88660.1; -; Genomic_DNA.
DR EMBL; Z47746; CAA87682.1; -; Genomic_DNA.
DR EMBL; AY557682; AAS56008.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA11952.1; -; Genomic_DNA.
DR PIR; S52672; S52672.
DR RefSeq; NP_010391.1; NM_001180414.1.
DR AlphaFoldDB; Q04549; -.
DR SMR; Q04549; -.
DR BioGRID; 32163; 78.
DR ComplexPortal; CPX-1805; Dynactin.
DR DIP; DIP-1204N; -.
DR IntAct; Q04549; 5.
DR MINT; Q04549; -.
DR STRING; 4932.YDR106W; -.
DR MaxQB; Q04549; -.
DR PaxDb; Q04549; -.
DR PRIDE; Q04549; -.
DR EnsemblFungi; YDR106W_mRNA; YDR106W; YDR106W.
DR GeneID; 851683; -.
DR KEGG; sce:YDR106W; -.
DR SGD; S000002513; ARP10.
DR VEuPathDB; FungiDB:YDR106W; -.
DR eggNOG; ENOG502S8RP; Eukaryota.
DR HOGENOM; CLU_085474_0_0_1; -.
DR InParanoid; Q04549; -.
DR OMA; SCNTRNA; -.
DR BioCyc; YEAST:G3O-29708-MON; -.
DR PRO; PR:Q04549; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; Q04549; protein.
DR GO; GO:0015629; C:actin cytoskeleton; IC:ComplexPortal.
DR GO; GO:0005737; C:cytoplasm; IDA:SGD.
DR GO; GO:0005869; C:dynactin complex; IPI:SGD.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0000812; C:Swr1 complex; IBA:GO_Central.
DR GO; GO:0031491; F:nucleosome binding; IBA:GO_Central.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IPI:SGD.
DR GO; GO:0030048; P:actin filament-based movement; IC:ComplexPortal.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IC:ComplexPortal.
DR GO; GO:0043486; P:histone exchange; IBA:GO_Central.
DR GO; GO:0000278; P:mitotic cell cycle; IGI:SGD.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR043129; ATPase_NBD.
DR Pfam; PF00022; Actin; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Dynein; Microtubule; Reference proteome.
FT CHAIN 1..284
FT /note="Actin-like protein ARP10"
FT /id="PRO_0000089130"
SQ SEQUENCE 284 AA; 33018 MW; C2EDD2B6D4BE48BD CRC64;
MSNTIVIVYL GANRIEIGRS ADACPQEIIA WKTGSINEKN REELKKIFEH YFQICNILGN
REVQVLILED IFISVVEKRI ICSILFKEFD CAHVSFVPRA IVHCLSCNTR NAIVIDIGTN
YTTCVPIFDL RPLQQFIKYS KRGKRQVESR IPLPGSLYMP IFFDEEYNSK NCEVDETPVI
NLVKNIVESL PIDLRRPLRE NIIIVNIEEA YETVIRNLFK LKMDTSKIQF PKNYWQAGSA
CAKILLHYKG SNIVGIERDE FYNNPHIAPD WFDYYFRTGV KRLQ
