ID   A20_VACCA               Reviewed;         426 AA.
AC   P68709; O57228; Q80HV4;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   02-JUN-2021, entry version 34.
DE   RecName: Full=DNA polymerase processivity factor component A20;
GN   OrderedLocusNames=MVA132R, ACAM3000_MVA_132;
OS   Vaccinia virus (strain Ankara) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=126794;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9601507; DOI=10.1006/viro.1998.9123;
RA   Antoine G., Scheiflinger F., Dorner F., Falkner F.G.;
RT   "The complete genomic sequence of the modified vaccinia Ankara strain:
RT   comparison with other orthopoxviruses.";
RL   Virology 244:365-396(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate Acambis 3000;
RA   Esposito J.J., Frace M., Sammons S.A., Olsen-Rasmussen M.S., Osborne J.,
RA   Khristova M., Wohlhueter R.M.;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an essential role in viral DNA replication by acting as
CC       the polymerase processivity factor together with protein D4. May serve
CC       as a bridge which links the DNA polymerase E9 and the uracil DNA
CC       glycosylase (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the DNA polymerase catalytic subunit E9.
CC       Interacts with UDG. Component of the Uracil-DNA glycosylase(UDG)-A20-
CC       polymerase complex; A20 and UDG form a heterodimeric processivity
CC       factor that associates with E9 to form the processive polymerase
CC       holoenzyme. Interacts with D5 (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviruses A20 family. {ECO:0000305}.
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DR   EMBL; U94848; AAB96523.1; -; Genomic_DNA.
DR   EMBL; AY603355; AAT10531.1; -; Genomic_DNA.
DR   PIR; T37408; T37408.
DR   RefSeq; YP_233023.1; NC_006998.1.
DR   SMR; P68709; -.
DR   DNASU; 3707671; -.
DR   GeneID; 3707671; -.
DR   KEGG; vg:3707671; -.
DR   Proteomes; UP000159908; Genome.
DR   Proteomes; UP000172909; Genome.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR010267; Chordopox_A20R.
DR   Pfam; PF05941; Chordopox_A20R; 1.
PE   3: Inferred from homology;
KW   DNA replication.
FT   CHAIN           1..426
FT                   /note="DNA polymerase processivity factor component A20"
FT                   /id="PRO_0000099266"
SQ   SEQUENCE   426 AA;  49074 MW;  650D8EE38CC76A78 CRC64;
     MTSSADLTNL KELLSLYKSL KFSDSAAIEK YNSLVEWGTS TYWKIGVQKV ANVETSISDY
     YDEVKNKPFN IDPGYYIFLP VYFGSVFIYS KGKNMVELGS GNSFQIPDDM RSACNKVLDS
     DNGIDFLRFV LLNNRWIMED AISKYQSPVN IFKLASEYGL NIPKYLEIEI EEDTLFDDEL
     YSIIERSFDD KFPKISISYI KLGELRRQVV DFFKFSFMYI ESIKVDRIGD NIFIPSVITK
     SGKKILVKDV DHLIRSKVRE HTFVKVKKKN TFSILYDYDG NGTETRGEVI KRIIDTIGRD
     YYVNGKYFSK VGSAGLKQLT NKLDINECAT VDELVDEINK SGTVKRKIKN QSAFDLSREC
     LGYPEADFIT LVNNMRFKIE NCKVVNFNIE NTNCLNNPSI ETIYGNFNQF VSIFNIVTDV
     KKRLFE