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ARP1_METAQ
ID   ARP1_METAQ              Reviewed;         446 AA.
AC   E9EHG0;
DT   05-DEC-2018, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 1.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=Scytalone dehydratase-like protein Arp1 {ECO:0000305|PubMed:29958281};
DE            EC=4.2.1.- {ECO:0000305|PubMed:29958281};
GN   Name=Arp1 {ECO:0000303|PubMed:29958281}; ORFNames=MAC_09308;
OS   Metarhizium acridum (strain CQMa 102).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX   NCBI_TaxID=655827;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CQMa 102;
RX   PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA   Gao Q., Jin K., Ying S.-H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA   Xie X.-Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA   Zhong Y., Ma L.-J., St Leger R.J., Zhao G.-P., Pei Y., Feng M.-G., Xia Y.,
RA   Wang C.;
RT   "Genome sequencing and comparative transcriptomics of the model
RT   entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL   PLoS Genet. 7:E1001264-E1001264(2011).
RN   [2]
RP   IDENTIFICATION, AND FUNCTION.
RX   PubMed=29958281; DOI=10.1371/journal.pgen.1007472;
RA   Zeng G., Zhang P., Zhang Q., Zhao H., Li Z., Zhang X., Wang C., Yin W.B.,
RA   Fang W.;
RT   "Duplication of a Pks gene cluster and subsequent functional
RT   diversification facilitate environmental adaptation in Metarhizium
RT   species.";
RL   PLoS Genet. 14:E1007472-E1007472(2018).
CC   -!- FUNCTION: Scytalone dehydratase-like protein; part of the Pks2 gene
CC       cluster that mediates the formation of infectious structures
CC       (appressoria), enabling these fungi to kill insects faster
CC       (PubMed:29958281). The product of the Pks2 gene cluster is different
CC       from the one of Pks1 and has still not been identified
CC       (PubMed:29958281). {ECO:0000269|PubMed:29958281}.
CC   -!- SUBUNIT: Homotrimer. Each subunit contains an active site, located in
CC       the central part of the hydrophobic core of the monomer, which
CC       functions independently. {ECO:0000250|UniProtKB:P56221}.
CC   -!- SIMILARITY: Belongs to the scytalone dehydratase family. {ECO:0000305}.
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DR   EMBL; GL698613; EFY84643.1; -; Genomic_DNA.
DR   RefSeq; XP_007815648.1; XM_007817457.1.
DR   AlphaFoldDB; E9EHG0; -.
DR   SMR; E9EHG0; -.
DR   STRING; 92637.XP_007815648.1; -.
DR   EnsemblFungi; EFY84643; EFY84643; MAC_09308.
DR   GeneID; 19253619; -.
DR   KEGG; maw:MAC_09308; -.
DR   eggNOG; KOG1211; Eukaryota.
DR   HOGENOM; CLU_614049_0_0_1; -.
DR   OrthoDB; 1377897at2759; -.
DR   Proteomes; UP000002499; Unassembled WGS sequence.
DR   GO; GO:0030411; F:scytalone dehydratase activity; IEA:InterPro.
DR   GO; GO:0006582; P:melanin metabolic process; IEA:InterPro.
DR   Gene3D; 3.90.1300.10; -; 1.
DR   InterPro; IPR000120; Amidase.
DR   InterPro; IPR023631; Amidase_dom.
DR   InterPro; IPR036928; AS_sf.
DR   InterPro; IPR032710; NTF2-like_dom_sf.
DR   InterPro; IPR004235; Scytalone_dehydratase.
DR   PANTHER; PTHR11895; PTHR11895; 2.
DR   Pfam; PF01425; Amidase; 1.
DR   Pfam; PF02982; Scytalone_dh; 1.
DR   SUPFAM; SSF54427; SSF54427; 1.
DR   SUPFAM; SSF75304; SSF75304; 1.
PE   3: Inferred from homology;
KW   Lyase; Reference proteome.
FT   CHAIN           1..446
FT                   /note="Scytalone dehydratase-like protein Arp1"
FT                   /id="PRO_0000445914"
FT   ACT_SITE        358
FT                   /evidence="ECO:0000250|UniProtKB:P56221"
FT   ACT_SITE        383
FT                   /evidence="ECO:0000250|UniProtKB:P56221"
FT   BINDING         323
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:P56221"
FT   BINDING         404
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:P56221"
SQ   SEQUENCE   446 AA;  48911 MW;  D126AB256C5ADA6A CRC64;
     MQNLTDKGAI IFGVQKTSQF ANGETATADW VDYHSPFNPR GDGYQDPATS SAGAGSSIAS
     YEWLDLAAGS DTGGSIRGPA AVQGIFGNRP SHGLISLDNA MPLSPKLDTP GFLARDPYLW
     NAANAALYRE NPLSRWSWGD SQPSSILSRN KTLFMNWFNE NILPRSSDPL TCSSGLLLHV
     DGSAGFISRN GYINPPVPPF GFSNGQISVF AETPDSVFPL GQVPAFSSIT NHTEYLPVTI
     NVVAAKGCDV LIAKLAEDMV AAGILKVLKI GAGIEGGEIL MRRYFVRDDG DEVMSRITSR
     GRLLFQDWDR LRGILAPTLY VDYTKIGKGK WEAMSADDFM AMVSNDDFLG DLCVKTQHLI
     GATSWERVSE SKVVGHHQLR AAHQVYTSPD LKTVKLRGHS HATNEHYYVK SDGVWKFAGL
     KPEVRWNEHK FEEVFKGSYT QSEKHS
 
 
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