ID   ARP21_BOVIN             Reviewed;          89 AA.
AC   Q7M2N1;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=cAMP-regulated phosphoprotein 21;
DE            Short=ARPP-21;
DE   AltName: Full=Regulator of calmodulin signaling;
GN   Name=ARPP21; Synonyms=RCS;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2552037; DOI=10.1523/jneurosci.09-10-03638.1989;
RA   Kurihara T., Ehrlich M.E., Horiuchi J., Nasu T., Greengard P.;
RT   "ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-
RT   innervated brain regions. II. Molecular cloning and nucleotide sequence.";
RL   J. Neurosci. 9:3638-3644(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Basal ganglia;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   PROTEIN SEQUENCE OF 2-89, ACETYLATION AT SER-2, AND PHOSPHORYLATION AT
RP   SER-56.
RX   PubMed=2552036; DOI=10.1523/jneurosci.09-10-03631.1989;
RA   Williams K.R., Hemmings H.C. Jr., LoPresti M.B., Greengard P.;
RT   "ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-
RT   innervated brain regions. I. Amino acid sequence of ARPP-21B from bovine
RT   caudate nucleus.";
RL   J. Neurosci. 9:3631-3637(1989).
RN   [4]
RP   INTERACTION WITH CALM1.
RX   PubMed=15499021; DOI=10.1126/science.1099961;
RA   Rakhilin S.V., Olson P.A., Nishi A., Starkova N.N., Fienberg A.A.,
RA   Nairn A.C., Surmeier D.J., Greengard P.;
RT   "A network of control mediated by regulator of calcium/calmodulin-dependent
RT   signaling.";
RL   Science 306:698-701(2004).
CC   -!- FUNCTION: May act as a competitive inhibitor of calmodulin-dependent
CC       enzymes such as calcineurin in neurons. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CALM1. {ECO:0000269|PubMed:15499021}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Phosphorylation at Ser-56 favors interaction with CALM1.
CC       {ECO:0000269|PubMed:2552036}.
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DR   EMBL; BC122647; AAI22648.1; -; mRNA.
DR   PIR; A34957; A34957.
DR   RefSeq; NP_001070418.1; NM_001076950.1.
DR   AlphaFoldDB; Q7M2N1; -.
DR   STRING; 9913.ENSBTAP00000053180; -.
DR   iPTMnet; Q7M2N1; -.
DR   PaxDb; Q7M2N1; -.
DR   Ensembl; ENSBTAT00000049002; ENSBTAP00000045948; ENSBTAG00000007732.
DR   GeneID; 618648; -.
DR   KEGG; bta:618648; -.
DR   CTD; 10777; -.
DR   VEuPathDB; HostDB:ENSBTAG00000007732; -.
DR   VGNC; VGNC:58588; ARPP21.
DR   eggNOG; KOG2953; Eukaryota.
DR   GeneTree; ENSGT00940000160796; -.
DR   HOGENOM; CLU_2256194_0_0_1; -.
DR   InParanoid; Q7M2N1; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000007732; Expressed in floor plate of diencephalon and 77 other tissues.
DR   ExpressionAtlas; Q7M2N1; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Acetylation; Calmodulin-binding; Cytoplasm; Direct protein sequencing;
KW   Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:2552036"
FT   CHAIN           2..89
FT                   /note="cAMP-regulated phosphoprotein 21"
FT                   /id="PRO_0000281925"
FT   REGION          1..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..59
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000269|PubMed:2552036"
FT   MOD_RES         33
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UBL0"
FT   MOD_RES         56
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:2552036"
FT   CONFLICT        26
FT                   /note="N -> D (in Ref. 3; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   89 AA;  9641 MW;  D37C5844C20CFA8B CRC64;
     MSEPGDLSQT IVEEGGPEQE TATPENGVIK SESLDEEEKL ELQRRLVAQN QERRKSKSGA
     GKGKLTRSLA VCEESSARPG GESLQDQTL